home
RSS
New Alzheimer's clues?
December 10th, 2010
09:12 AM ET

New Alzheimer's clues?

Preliminary research on Alzheimer's disease suggests a protein that accumulates in the brain at very high levels in Alzheimer's patients is not being overproduced, it's just not being cleared efficiently from the brain.

The study, published in Science, measured beta-amyloid levels in the cerebrospinal fluid of twelve 74-year old patients with late-onset Alzheimer's and twelve without. Researchers looked at how fast beta-amyloid was produced and how quickly it cleared the brain.

"These findings may help point us toward better diagnostic tests and effective therapies," said study author Dr. Randall Bateman. "The next question is what is causing the decreased clearance rate."

Researchers say the study is significant because it's the first to measure beta-amyloid production and clearance–long thought to be an underlying cause of the disease–and could lead to an easier test–possibly a blood test–that will measure the protein early enough to detect Alzheimer's before symptoms begin.

"Abnormal protein deposits within the brain are a hallmark not only of Alzheimer's disease, but of many neurological disorders," said Roderick Corriveau, a program director at the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health. "With knowledge about how these proteins accumulate, we may be able to slow that process and reduce the damage to the brain."

"For years scientists believed that it was the overproduction of beta-amyloid that led to its accumulation in the brain," said Marcelle Morrison-Bogorad, director of the Division of Neuroscience at the NIA. "These new findings shift the emphasis to clearance of beta-amyloid. This may lead to development of a diagnostic test as well as identification of new therapeutic targets."

More than 5 million Americans have Alzheimer's disease, the most common cause of dementia in the elderly. According to the Alzheimer's Association's Dr. Ralph Nixon, Vice Chair, Medical & Scientific Advisory Council,  this research adds human validation to the puzzle of how amyloid beta accumulates in the brain. "It is the first data of this kind in a human," and, as such, provides key preliminary validation to studies in animal models, which are incomplete and often give conflicting information."


soundoff (295 Responses)
  1. RfvbZisse

    cialis pill https://cileve.com/ – google south africa cialis 36 hour cialis mg

    April 26, 2021 at 20:23 | Report abuse | Reply
  2. LhdvZisse

    cialis store in philippines https://asciled.com/ paypal cialis

    April 27, 2021 at 01:42 | Report abuse | Reply
  3. AbdgEncox

    Augmentin https://canadianeve21.com/ Brand Cialis

    April 27, 2021 at 21:25 | Report abuse | Reply
  4. LrbsEncox

    price for levitra pastilla levitra levitra best dosage

    April 28, 2021 at 16:43 | Report abuse | Reply
  5. LrbsEncox

    levitra remedio http://uslevitraanna.com/ levitra sales

    April 28, 2021 at 19:46 | Report abuse | Reply
  6. LhdvZisse

    cialis quick ship http://asciled.com/ – cialis in manitoba generic cialis sale

    May 1, 2021 at 11:06 | Report abuse | Reply
  7. JbsdEncox

    pharmacy prices compare http://onlinecanda21.com/ online drugstore pharmacy

    May 1, 2021 at 12:47 | Report abuse | Reply
  8. JbsdEncox

    Lamivudin (Cipla Ltd) https://onlinecanda21.com/ Cabgolin

    May 2, 2021 at 06:39 | Report abuse | Reply
  9. RfvbZisse

    cialis price http://cileve.com/ cialis super active for cheap

    May 2, 2021 at 15:25 | Report abuse | Reply
  10. FbsfEncox

    canada pharmacies without script https://uspharmus.com/ online prescription drugs

    May 2, 2021 at 22:30 | Report abuse | Reply
  11. GvdbCrulk

    aurochem tadalafil https://boxtadafil.com/ cialis tadalafil 20mg price

    May 2, 2021 at 22:58 | Report abuse | Reply
  12. GtnbCrulk

    how well does viagra work http://jokviagra.com/ viagra over the counter walmart

    May 3, 2021 at 21:26 | Report abuse | Reply
  13. GtnbCrulk

    viagra falls http://jokviagra.com/ pfizer viagra

    May 4, 2021 at 14:22 | Report abuse | Reply
  14. JebgEncox

    Hyzaar https://pharmacylo.com/ canadian family pharmacy

    May 4, 2021 at 18:59 | Report abuse | Reply
  15. BbshMile

    viagra cialis levitra https://loxviagra.com/ which presidential candidate was the first spokesman for viagra

    May 5, 2021 at 01:23 | Report abuse | Reply
  16. JebgEncox

    online pharmacy usa http://pharmacylo.com/ list of approved canadian pharmacies

    May 5, 2021 at 09:01 | Report abuse | Reply
  17. LbsoZisse

    cialis no prescription https://ucialisdas.com/ – cheapest cialis on the web cialis generic date

    May 5, 2021 at 13:54 | Report abuse | Reply
  18. BbshMile

    how much is a viagra pill http://loxviagra.com/ viagra connect

    May 5, 2021 at 21:13 | Report abuse | Reply
  19. FmrfEncox

    cialis overnight https://cialisee.com/ buy cialis withiut a prescription

    May 6, 2021 at 00:05 | Report abuse | Reply
  20. RebfZisse

    cialis black http://rcialisgl.com/ prescription for cialis purchase

    May 6, 2021 at 17:15 | Report abuse | Reply
  21. FmrfEncox

    canada cialis with dapoxetine https://cialisee.com/ buy cialis

    May 7, 2021 at 07:07 | Report abuse | Reply
  22. AnooEncox

    viagra powГіd wynalezienia http://llviagra.com/ porque el viagra no me sirve

    May 7, 2021 at 21:26 | Report abuse | Reply
  23. RebfZisse

    cialis tadalafil & dapoxetine https://rcialisgl.com/ buy cialis brand

    May 8, 2021 at 01:20 | Report abuse | Reply
  24. LbsoZisse

    cialis trial pack http://ucialisdas.com/ – cialis 36 hours female cialis online

    May 8, 2021 at 06:04 | Report abuse | Reply
  25. AnooEncox

    viagra en el neonato https://llviagra.com/ – jaime bayly viagra benefit of viagra tablet

    May 9, 2021 at 04:51 | Report abuse | Reply
  26. LebnEncox

    canadian online pharmacy https://xlnpharmacy.com/ ed meds online without doctor prescription

    May 9, 2021 at 13:19 | Report abuse | Reply
  27. LebnEncox

    Dulcolax pharmacy open near me peoples pharmacy

    May 9, 2021 at 16:37 | Report abuse | Reply
  28. GtnbCrulk

    viagra coupon walgreens https://jokviagra.com/ viagra coupon

    May 10, 2021 at 21:35 | Report abuse | Reply
  29. GtnbCrulk

    viagra online prescription https://jokviagra.com/ – best viagra online viagra 100mg cost

    May 11, 2021 at 19:37 | Report abuse | Reply
  30. BbshMile

    is viagra covered by medicare http://loxviagra.com/ lady viagra

    May 12, 2021 at 14:56 | Report abuse | Reply
  31. LbsoZisse

    cialis generic china https://ucialisdas.com/ – cialis paypale buy cialis brand

    May 12, 2021 at 18:20 | Report abuse | Reply
  32. JebgEncox

    discount pharmacy online list of online pharmacies Coreg

    May 12, 2021 at 23:44 | Report abuse | Reply
  33. FmrfEncox

    why buy cialis. com https://cialisee.com/ cialis best price

    May 13, 2021 at 03:08 | Report abuse | Reply
  34. BbshMile

    what is the difference between viagra and cialis http://loxviagra.com/ – viagra results viagra for men free samples

    May 13, 2021 at 10:08 | Report abuse | Reply
  35. JebgEncox

    wall drug store https://pharmacylo.com/ Tofranil

    May 13, 2021 at 18:34 | Report abuse | Reply
  36. RebfZisse

    buy cialis online overnight delivery http://rcialisgl.com/ – receive cialis overnight cialis overnight online

    May 13, 2021 at 22:36 | Report abuse | Reply
  37. FmrfEncox

    cialis uk https://cialisee.com/ cialis professional legitimate

    May 14, 2021 at 06:04 | Report abuse | Reply
  38. AnooEncox

    viapro vs viagra http://llviagra.com/ female viagra experiences

    May 14, 2021 at 16:22 | Report abuse | Reply
  39. RebfZisse

    generic cialis no prescription https://rcialisgl.com/ cialis black to buy in the uk

    May 15, 2021 at 04:45 | Report abuse | Reply
  40. LbsoZisse

    cialis one a day https://ucialisdas.com/ generic cialis overnight delivery

    May 15, 2021 at 09:16 | Report abuse | Reply
  41. AnooEncox

    viagra delivery lima http://llviagra.com/ what to do if a child swallows viagra

    May 15, 2021 at 21:06 | Report abuse | Reply
  42. LebnEncox

    canadian mail order pharmacies Atorlip-5 canadian drugstore

    May 17, 2021 at 01:04 | Report abuse | Reply
  43. LebnEncox

    indian pharmacy online canadian pharmacy world buying prescription drugs canada

    May 17, 2021 at 03:17 | Report abuse | Reply
  44. JebgEncox

    cheap drugs online cheap canadian pharmacy rx price comparison

    May 18, 2021 at 16:34 | Report abuse | Reply
  45. LbsoZisse

    cialis sales http://ucialisdas.com/ purchase generic cialis

    May 19, 2021 at 07:29 | Report abuse | Reply
  46. JebgEncox

    Coversyl Sinequan canadapharmacyonline com

    May 19, 2021 at 10:02 | Report abuse | Reply
  47. GtnbCrulk

    side effects of viagra in older men http://jokviagra.com/ viagra prescription online

    May 19, 2021 at 20:58 | Report abuse | Reply
  48. FmrfEncox

    cialis soft tabs 20mg http://cialisee.com/ best online to buy cialis

    May 19, 2021 at 22:46 | Report abuse | Reply
  49. RebfZisse

    buy cialis online https://rcialisgl.com/ cialis 20 mg from united kingdom

    May 20, 2021 at 07:21 | Report abuse | Reply
  50. GtnbCrulk

    snort viagra http://jokviagra.com/ viagra duration

    May 20, 2021 at 15:41 | Report abuse | Reply
1 2 3 4 5 6

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.