home
RSS
New Alzheimer's clues?
December 10th, 2010
09:12 AM ET

New Alzheimer's clues?

Preliminary research on Alzheimer's disease suggests a protein that accumulates in the brain at very high levels in Alzheimer's patients is not being overproduced, it's just not being cleared efficiently from the brain.

The study, published in Science, measured beta-amyloid levels in the cerebrospinal fluid of twelve 74-year old patients with late-onset Alzheimer's and twelve without. Researchers looked at how fast beta-amyloid was produced and how quickly it cleared the brain.

"These findings may help point us toward better diagnostic tests and effective therapies," said study author Dr. Randall Bateman. "The next question is what is causing the decreased clearance rate."

Researchers say the study is significant because it's the first to measure beta-amyloid production and clearance–long thought to be an underlying cause of the disease–and could lead to an easier test–possibly a blood test–that will measure the protein early enough to detect Alzheimer's before symptoms begin.

"Abnormal protein deposits within the brain are a hallmark not only of Alzheimer's disease, but of many neurological disorders," said Roderick Corriveau, a program director at the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health. "With knowledge about how these proteins accumulate, we may be able to slow that process and reduce the damage to the brain."

"For years scientists believed that it was the overproduction of beta-amyloid that led to its accumulation in the brain," said Marcelle Morrison-Bogorad, director of the Division of Neuroscience at the NIA. "These new findings shift the emphasis to clearance of beta-amyloid. This may lead to development of a diagnostic test as well as identification of new therapeutic targets."

More than 5 million Americans have Alzheimer's disease, the most common cause of dementia in the elderly. According to the Alzheimer's Association's Dr. Ralph Nixon, Vice Chair, Medical & Scientific Advisory Council,  this research adds human validation to the puzzle of how amyloid beta accumulates in the brain. "It is the first data of this kind in a human," and, as such, provides key preliminary validation to studies in animal models, which are incomplete and often give conflicting information."


soundoff (183 Responses)
  1. JnscCrulk

    low cost viagra viagra purchase in kuwait viagra with dapoxetine without prescription mastercard http://erectilejyzd.com/index.php?called=terms – viagra 40mg ’

    February 1, 2021 at 00:20 | Report abuse | Reply
  2. Shara Saterfiel

    This is a very interesting article. Please, share more like this!

    https://yt1s.com

    February 1, 2021 at 05:29 | Report abuse | Reply
  3. Dori Bevels

    This is a very interesting article. Please, share more like this!

    https://yt1s.com/facebook-downloader

    February 1, 2021 at 10:00 | Report abuse | Reply
  4. KbcxMile

    weight loss prescription drugs canada pharmacy online shopping

    February 4, 2021 at 16:45 | Report abuse | Reply
  5. FvfcZisse

    canadian generic viagra chap viagra actually pay with paypal viagra

    February 4, 2021 at 20:45 | Report abuse | Reply
  6. LbsxEncox

    canada pharmacies canadian viagra buy via paypal canadian pharmacies without an rx

    February 5, 2021 at 13:12 | Report abuse | Reply
  7. JbnbCrulk

    pharmacy drug store no prescription pharmacies overseas pharmacies

    February 5, 2021 at 23:50 | Report abuse | Reply
  8. AqcfTeneseelt

    cialis vs viagra vs kamagra brand cialis online buy brand cialis overnight

    February 6, 2021 at 01:20 | Report abuse | Reply
  9. FqhhEncox

    canadian rx pharmacy online canadian drugs pharmacies online pharmacy northwest canada

    February 7, 2021 at 02:26 | Report abuse | Reply
  10. JbbvEncox

    pharmacy price compare no 1 canadian pharcharmy online Brand Viagra

    February 7, 2021 at 15:01 | Report abuse | Reply
  11. NncsZisse

    how to get viagra toronto buy generic viagra i want viagra

    February 8, 2021 at 19:27 | Report abuse | Reply
  12. AhkdEncox

    board of pharmacy cialis canada viagra professional

    February 9, 2021 at 19:26 | Report abuse | Reply
  13. Kuikseelt

    comprare viagra con paypal no prescription viagra vipp is viagra from canada safe?

    February 9, 2021 at 20:33 | Report abuse | Reply
  14. KvaxMile

    payday loans sandy oregon cash advance franklin nh payday loan payment plan

    February 11, 2021 at 14:41 | Report abuse | Reply
  15. hydroxychloroquine coronavirus study

    hydroxychoroquine hydroxyquinoline what is hydroxychloride

    February 12, 2021 at 08:49 | Report abuse | Reply
  16. LabxEncox

    cialis skelbiu where to buy cialis in mexico cialis tutti giorni

    February 12, 2021 at 11:49 | Report abuse | Reply
  17. FbsgZisse

    toronto buy cialis http://llecialisjaw.com/ cialis marke 20mg

    February 12, 2021 at 18:21 | Report abuse | Reply
  18. AbcfTeneseelt

    what is more effective,cialis or viagra? http://viagriyvik.com/ can i buy viagra over the counter in the us

    February 13, 2021 at 01:17 | Report abuse | Reply
  19. JbnvCrulk

    http://www.my payday advance.com payday loans phoenix dubai money loan

    February 13, 2021 at 01:22 | Report abuse | Reply
  20. JbbnEncox

    cialis massima efficacia dopo cuanto tiempo debo tomar cialis legal cialis uk

    February 14, 2021 at 07:31 | Report abuse | Reply
  21. FqbbEncox

    payday loans in harahan la white mountain payday loans cash advance direct lenders canada

    February 15, 2021 at 06:18 | Report abuse | Reply
  22. NbnhZisse

    where to buy viagra over the counter in usa brand viagra online australia how much is sildenafil 25 mg

    February 16, 2021 at 22:39 | Report abuse | Reply
  23. AhbzEncox

    quick cash loans bundaberg nc law against payday loans payday loans direct lender online

    February 17, 2021 at 23:48 | Report abuse | Reply
  24. buy chloroquine online

    chloroquine cvs aralen phosphate chloroquine phosphate chloroguine

    February 18, 2021 at 16:22 | Report abuse | Reply
  25. Kbbfseelt

    buy gerneric viagra viagra for women online australia online viagra

    February 18, 2021 at 19:28 | Report abuse | Reply
  26. buy tadalafil us

    tadifil buy tadalafil us tadifil

    February 19, 2021 at 16:04 | Report abuse | Reply
  27. KndnMile

    viagra information viagra company cheapest viagra

    February 27, 2021 at 09:05 | Report abuse | Reply
  28. FjjuZisse

    female viagra pill http://viagraonlinejc.com/ off brand viagra

    February 27, 2021 at 18:10 | Report abuse | Reply
  29. NbmoZisse

    cialis prices cialis ordering cialis for sale in toronto

    March 3, 2021 at 11:00 | Report abuse | Reply
  30. LmoppEncox

    http://essaywriteris.com/ – english essay writers buy essays cheap essay writers review buy cheap essays

    March 24, 2021 at 06:20 | Report abuse | Reply
  31. BrfgMile

    https://ljcialishe.com/ – what happens if a woman takes cialis https://cialisvja.com/ – does cialis lowers blood pressure https://viagraonlinejc.com/ – viagra meme https://viagratx.com/ – average age of man taking viagra https://buycialisxz.com/ – cialis commercial 2016

    March 25, 2021 at 10:31 | Report abuse | Reply
  32. JvqqEncox

    https://dissertationahelp.com/ – example dissertation master dissertation dissertation only phd write a dissertation

    March 25, 2021 at 22:12 | Report abuse | Reply
  33. GrvCrulk

    https://kloviagrli.com/ – buy viagra connect usa https://vigedon.com/ – viagra over the counter walmart https://llecialisjaw.com/ – levitra vs cialis https://jwcialislrt.com/ – cialis review https://jecialisbn.com/ – when can i take viagra after taking cialis

    March 26, 2021 at 09:09 | Report abuse | Reply
  34. jarge Playmn

    Hello! It's a best video downloader online – FastFrom, allows to save all videos from internet to you mobile or PC.

    https://hero.osclass.me/user/profile/320678
    https://community.fandom.com/wiki/User:Josepsina
    https://issuu.com/fastfrom.com
    https://itsmyurls.com/yellowgreen
    https://leanpub.com/u/james997
    https://pikabu.ru/@armoredik
    https://logos.fandom.com/wiki/FastFrom.com

    March 29, 2021 at 05:19 | Report abuse | Reply
  35. FbshEncox

    https://thesisacloud.com/ – writing my thesis writing the thesis thesis chapters thesis paper

    April 2, 2021 at 22:16 | Report abuse | Reply
  36. 40 mg tadalafil

    tadalafil online https://elitadalafill.com/ tadalafil online

    April 6, 2021 at 07:12 | Report abuse | Reply
  37. sildenafil cheapest price in india

    sildenafil 100 mexico https://eunicesildenafilcitrate.com/ sildenafil 20 mg tablet

    April 7, 2021 at 05:05 | Report abuse | Reply
  38. generic vardenafil 20mg india

    side effects for vardenafil https://vegavardenafil.com/ generic vardenafil 20mg

    April 8, 2021 at 00:45 | Report abuse | Reply
  39. alprostadil pellets

    cheap alprostadil https://alprostadildrugs.com/ alprostadil cream for sale

    April 8, 2021 at 02:40 | Report abuse | Reply
1 2 3

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.