home
RSS
New Alzheimer's clues?
December 10th, 2010
09:12 AM ET

New Alzheimer's clues?

Preliminary research on Alzheimer's disease suggests a protein that accumulates in the brain at very high levels in Alzheimer's patients is not being overproduced, it's just not being cleared efficiently from the brain.

The study, published in Science, measured beta-amyloid levels in the cerebrospinal fluid of twelve 74-year old patients with late-onset Alzheimer's and twelve without. Researchers looked at how fast beta-amyloid was produced and how quickly it cleared the brain.

"These findings may help point us toward better diagnostic tests and effective therapies," said study author Dr. Randall Bateman. "The next question is what is causing the decreased clearance rate."

Researchers say the study is significant because it's the first to measure beta-amyloid production and clearance–long thought to be an underlying cause of the disease–and could lead to an easier test–possibly a blood test–that will measure the protein early enough to detect Alzheimer's before symptoms begin.

"Abnormal protein deposits within the brain are a hallmark not only of Alzheimer's disease, but of many neurological disorders," said Roderick Corriveau, a program director at the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health. "With knowledge about how these proteins accumulate, we may be able to slow that process and reduce the damage to the brain."

"For years scientists believed that it was the overproduction of beta-amyloid that led to its accumulation in the brain," said Marcelle Morrison-Bogorad, director of the Division of Neuroscience at the NIA. "These new findings shift the emphasis to clearance of beta-amyloid. This may lead to development of a diagnostic test as well as identification of new therapeutic targets."

More than 5 million Americans have Alzheimer's disease, the most common cause of dementia in the elderly. According to the Alzheimer's Association's Dr. Ralph Nixon, Vice Chair, Medical & Scientific Advisory Council,  this research adds human validation to the puzzle of how amyloid beta accumulates in the brain. "It is the first data of this kind in a human," and, as such, provides key preliminary validation to studies in animal models, which are incomplete and often give conflicting information."


soundoff (132 Responses)
  1. KbrgMile

    how to order viagra in india how to buy viagra from canada viagra otc uk

    November 25, 2020 at 08:38 | Report abuse | Reply
  2. FmsgEncox

    young men on viagra can u drink alcohol while on viagra viagra headquarters bushes

    November 27, 2020 at 04:03 | Report abuse | Reply
  3. FnrhEncox

    viagra from canada with out a prescription viagra by pills viagra gold 800 mg

    November 27, 2020 at 14:56 | Report abuse | Reply
  4. FtghEncox

    personal statement medical literature research proposal help with my personal statement

    November 29, 2020 at 07:23 | Report abuse | Reply
  5. JgscCrulk

    research paper king tut dog ate homework type my essay

    November 29, 2020 at 08:32 | Report abuse | Reply
  6. FsfEncox

    essay service project presentation writing a speech

    November 29, 2020 at 15:57 | Report abuse | Reply
  7. FgsZisse

    help me on my math homework best books to write an essay on writing an introduction speech

    November 30, 2020 at 01:58 | Report abuse | Reply
  8. KwgdMile

    get someone to write your essay value of education college essay help in writing an essay

    November 30, 2020 at 14:13 | Report abuse | Reply
  9. FnsbEncox

    writing a conclusion to a research paper research paper heading architectural thesis proposal

    November 30, 2020 at 15:58 | Report abuse | Reply
  10. FqfEncox

    cover letters for employment proper heading for college essay assignment writing help

    December 1, 2020 at 05:43 | Report abuse | Reply
  11. FnrdEncox

    viagra dosages viagra ireland windsor viagra

    December 1, 2020 at 18:20 | Report abuse | Reply
  12. DvscZisse

    essay writing wikipedia essay writing review leadership essay writing

    December 2, 2020 at 23:21 | Report abuse | Reply
  13. FgnsZisse

    cialis20mg is there a legal generic cialis made in the united states cialis without prescription

    December 9, 2020 at 23:37 | Report abuse | Reply
  14. FgrsEncox

    viagra heartburn generic viagra in australia viagra online plus 2 free viagra

    December 10, 2020 at 08:57 | Report abuse | Reply
  15. FbsbEncox

    buy cialis on line without presciption where can i buy cialis online cialis no prescription

    December 10, 2020 at 10:35 | Report abuse | Reply
  16. FsfgEncox

    price of viagra where to buy viagra chemist austrlia walmart viagra price

    December 10, 2020 at 15:48 | Report abuse | Reply
  17. JgsvCrulk

    800mg viagra gold viagra online pfizer viagra 100mg

    December 10, 2020 at 20:17 | Report abuse | Reply
  18. FqbfEncox

    generic cialis or tadalafil cialis for sale cialis coupon voucher

    December 11, 2020 at 19:19 | Report abuse | Reply
  19. KhedMile

    buy viagra in spain safe cheap viagra online buy indian viagra

    December 12, 2020 at 04:13 | Report abuse | Reply
  20. DvncZisse

    cialis australia buy cialis black cialis greece

    December 12, 2020 at 14:46 | Report abuse | Reply
  21. FhsnZisse

    viagra canada viagra canada viagra gold for sale

    December 14, 2020 at 21:04 | Report abuse | Reply
  22. DvnjZisse

    the real viagra for sale wildviagra \'generic viagra\' 50 mg 30 pills

    December 17, 2020 at 14:16 | Report abuse | Reply
  23. JtmfEncox

    best ed medication online pharmacy drugstore online pharmacies

    January 8, 2021 at 14:21 | Report abuse | Reply
  24. KhthMile

    drugstore canadian pharmacy viagra peoples drug store

    January 8, 2021 at 18:08 | Report abuse | Reply
  25. LokuEncox

    erectile dysfunction erectile dysfunction medications save on pharmacy

    January 9, 2021 at 02:03 | Report abuse | Reply
  26. AqwsEncox

    pharmacy 24 hr pharmacy near me ed treatment

    January 10, 2021 at 07:52 | Report abuse | Reply
  27. FgvdZisse

    medical pharmacy pharmacy online drugstore best erectile dysfunction pills

    January 10, 2021 at 16:30 | Report abuse | Reply
  28. FwsxEncox

    ed pills online best drugstore moisturizer ed drugs

    January 11, 2021 at 09:49 | Report abuse | Reply
  29. NllpZisse

    dysfunction http://pharmacy-onlineasxs.com/ drug store news

    January 12, 2021 at 10:29 | Report abuse | Reply
  30. KlioMile

    generic viagra review viagra act canada viagra with dapoxetine windsor canada viagra viagra for dogs online youtube viagra best viagra deals from india where to buy viagra in melbourne buy viagra without perscription viagra in usa generic viagra free shipping non prescription viagra las vegas nv where to buy viagra in melbourne viagra canada pfizer viagra for sale us

    January 13, 2021 at 12:49 | Report abuse | Reply
  31. FgnhZisse

    purchase viagra without prescription viagra buy in melbourne viagra prescription insurance priligy and viagra purchase viagra melbourne viagra black market buy viagra without rx shoppers drug mart viagra viagra professional super viagraaustralia india very cheapest price on viagra. viagra for sal viagra online bestellen org can i buy viagra over the counter in canada viagra hong kong

    January 14, 2021 at 20:26 | Report abuse | Reply
  32. NlbxZisse

    viagra over night delivery buy viagra 100 mg online buying viagra in uk online viagra 100mg pfizer viagra india pharmacy viagra alternatives cheapest place to buy viagra viagra,inexpensive,no prescription cheap viagra in us women viagra for sale viagra en portland no online no prescription viagra mastercard trial pack viagra levitra free viagra trial offer viagra buy canada

    January 16, 2021 at 13:13 | Report abuse | Reply
  33. JvcxCrulk

    viagra cheapest online cheapest viagra online discovercard viagra viagra patent generic viagra canada customs best viagra source buy oral viagra online viagra for no prisiption chep viagra generic viagra usa canada buy viagra using paypal can i buy viagra using paypal men on viagra videos brand viagra buy viagra without prescription?

    January 17, 2021 at 16:12 | Report abuse | Reply
  34. JbdcEncox

    viagra. low price viagra viagra for sale cheapest http://llviabest.com/ – fast shipping on viagra au ’

    January 18, 2021 at 10:08 | Report abuse | Reply
  35. KbctMile

    buy cialis online using paypal buy cialis without prescription cialis 36 hour online http://mycialedst.com/ – generic cialis no prescription ’

    January 18, 2021 at 13:08 | Report abuse | Reply
  36. LcxEncox

    viagra paypal australia viagra usa ship viagra to canada http://genqpviag.com/ – shoppers drug mart viagra ’

    January 18, 2021 at 21:31 | Report abuse | Reply
  37. FbdhZisse

    cialis dapoxetine cialis debit card cialis dapoxetine australia http://21cialismen.com/ – cialis superactive ’

    January 19, 2021 at 20:43 | Report abuse | Reply
  38. AqbvEncox

    viagra price comparison uk walgreen viagra viagra dapoxetine http://acialaarx.com/ – viagra without prescription\' ’

    January 20, 2021 at 02:41 | Report abuse | Reply
1 2

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.