October 29th, 2010
10:13 AM ET

FDA rejects new diet drug

The U.S. Food and Drug Administration has rejected the approval of Qnexa, an experimental drug used to treat obesity.

The FDA told the drug maker, Vivus, that the drug could not be approved in its present form, the company said Thursday in a statement. Qnexa is a combination of two older medications: phentermine, an amphetamine that made up the "phen" half of Fen-Phen, the diet drug pulled from the market in the 1990s after some users developed heart problems. The second component of Qnexa is topiramate, an anti-seizure medication that's been used to treat a range of conditions, including alcoholism.

The FDA's decision does not come a surprise. In July, an FDA advisory committee recommended Qnexa not be approved, citing concerns ranging from heart issues to psychiatric side effects. The company says it is not going to give up. "We remain confident in the efficacy of Qnexa and look forward to continue working with the FDA towards the approval for the treatment of obesity," said Leland Wilson, chief executive officer of Vivus.  The company plans to respond to the FDA around mid-December.

soundoff (234 Responses)
  1. chris

    I know of a not-so-experimental drug that treats obesity rather well...it's called Exercisium

    October 29, 2010 at 10:35 | Report abuse | Reply
    • Zeppelin

      That's fascinating! Where does one get this drug? 🙂

      October 29, 2010 at 12:06 | Report abuse |
    • Kate

      Wrong answer Chris. Recent studies have found that weight loss is 80% diet and only 20% exercise.

      October 29, 2010 at 13:31 | Report abuse |
    • Valerie

      Wonderful Kate!

      Which further proves fat people CAN control their weight, provided they actually CARE enough about themselves to eat right.

      You aren't going to loose weight eating garbage.

      October 29, 2010 at 15:36 | Report abuse |
    • eeyore

      "Loose weight"? Yeah, I'll be sure to listen to your advice, brainiac.

      October 30, 2010 at 10:07 | Report abuse |
    • Improve Concentration

      Friggin Hilarious – side effects, abs

      Improve Concentration

      October 30, 2010 at 15:36 | Report abuse |
    • Other Valerie

      Hey eeyore, there are at least two Valeries posting, and that one's not me. To the other Valerie, don't take offense at eeyore's spelling police posts and random ad hominem attacking, she thinks that you're me and she just can't change her troll nature. Feel free to keep ignoring her.

      October 31, 2010 at 10:26 | Report abuse |
  2. Michelle

    Rx for weight loss: Take one half-grapefruit plus a bowl of cheerios in the morning, a small sandwich at lunch (hold the mayo), and four ounces of lean chicken with a plate full of lightly steamed or sauteed vegetables in the evening. Get 30 minutes of moderate-to-intense cardiovascular activity during waking hours. Repeat daily.

    October 29, 2010 at 10:40 | Report abuse | Reply
    • Zeppelin

      Best advice I've seen on this board thus far!

      October 29, 2010 at 12:06 | Report abuse |
    • Brenda

      Common sense! NO!!

      October 29, 2010 at 12:33 | Report abuse |
    • KateB

      "Michelle" under your plan – that's *does a calculation* only around 800-900 calories a day, so a starvation diet for a normal woman, and absolutely a starvation diet for a man. I'd recommend never going under 1400 calories a day, exercise 30 minutes 5 days/week and just about anyone will be quite trim in about 6-12 months and much happier due to a more varied diet.

      October 29, 2010 at 13:36 | Report abuse |
    • David

      I agree with KateB, partly for Calorie reasons, but also because that diet plan isn;t going to meet vit/min needs. So: add that same plate of veggies to the other two meals and add a couple of cups of non-fat yogurt or 1% milk and you'll be doing pretty well.

      October 29, 2010 at 14:17 | Report abuse |
    • TJ

      Sorry Michelle but eating RIGHT and exercise is the answer not a boring one meal diet over your lifetime.

      October 29, 2010 at 15:07 | Report abuse |
    • Josh

      Just exercise and eat well. There is no healthier way to weight loss. Stop making excuses about not having time. Stop saying you've tried everything because you haven't. Just do it and stop lying to others and yourself about how you "can't lose weight"

      October 29, 2010 at 15:53 | Report abuse |
    • asdf

      I enjoy a good metabolism.

      October 29, 2010 at 16:39 | Report abuse |
  3. Lak250

    I've taken topiramate (Topamax) a few times for migraines and each time I stopped it because of the cognitive side effects. I can't imagine what it would be like mixed with phentermine.

    October 29, 2010 at 10:49 | Report abuse | Reply
    • Shoebox22

      I also took topiramate for several years to control migraines and yes, it does stop your desire for food, but unfortunately it also affects memory and how your brain processes information. It took over a year to get back to normal and I have lost memories for that time still; I guess permanently.
      I wouldn't recommend taking it unless your condition was severe (mine was) and all other milder (less side effects) options had been exhausted.
      You've only got one brain.

      October 29, 2010 at 13:17 | Report abuse |
    • RebeccaS

      I took Topamax for several years for migraines as well, and it's not a drug I would recommend for anyone, except those that _really_ need it. The cognitive disfunction it causes is NOT fun, and can be very difficult to deal with. I've been off the drug for 2 years now, and I swear it caused some sort of permanent damage, because I still have a lot of trouble with finding words and gathering my thoughts together (I'm only in my early 30's, so I doubt it's age related!) This is not a drug that should be handed out like candy.

      October 29, 2010 at 13:36 | Report abuse |
    • Linda

      I have been taking Topamax for years (also in my mid 30s). It did cause cognitive issues at first. I adjusted after a few months, and found it to be a LIFESAVER, as it was the only drug that stopped my dehabilitating migraines that I had been suffering with for over 10 years. Everyone is different. I also noticed that is absolutely controlled my appetite (and when I did crave food, I wanted healty stuff), which at 105 pounds and 5"2' was not something that mattered to me, but that also wroe off over time.

      October 29, 2010 at 16:03 | Report abuse |
    • Improve Concentration

      A common sense approach.

      Improve Concentration

      October 30, 2010 at 15:41 | Report abuse |
    • O.Poe

      I agree. I had severe facial pain of causes unknown and a neurologist put me on Topomax and told me I had a migraine. The side effects of the drug for me were so severe they had to take me off of it. I was fortunate enough to find another neurologist willing to listen to me. I wouldn't take this drug again.

      November 1, 2010 at 19:30 | Report abuse |
  4. Momofthree

    weight loss is not simple for everyone. I have been on a roller coaster with my weight since I hit puberty. I eat less than the recommended calories daily and although I do indulge occasionally on something sweet my diet is damn near ideal. That being said, because I cannot devote my LIFE to working out, like I did as a teenager (and still never reached my ideal weight) I will always remain over weight. In some cases, there are metabolic issues that have nothing to do with lack of exercise or poor eating habits. I exercise daily, I eat healthy and I don't drink sugar laden drinks yet I remain overweight. Explain that one? Please don't lump all obese people into the same category. We aren't all responsible for how we got the way we are.

    October 29, 2010 at 10:53 | Report abuse | Reply
    • Brenda

      You intake of calaries IS NOT right for YOU. Reduce your calories to where YOUR body says it's enough and get outside.

      October 29, 2010 at 12:35 | Report abuse |
    • dt

      Ever heard of a self-fulfilling prophecy?? In my experience there is almost always a connection with people like you, and by people like you I mean people who are motivated to lose weight, but are improperly educated. You are probably still eating unhealthy. You cut out what you thought was the ONLY problem, and are not seeing results. By your comment, and your commitment to only calories as a measure of health, I think there is probably a lot of research you have left to do.

      October 29, 2010 at 12:41 | Report abuse |
    • Daina

      I do not imagine it is easy (I've always been thin with little effeort) I eat when I'm hungry but I do not like feeling stuffed so it's never large amounts but it's not metabolic else it would be easily proven by blood tests. There are genetic components to everything so I am sure that those with obese parents will have a harder go of it (somewhat guesswork as genetically I coast thru not putting on weight) I also NEVER go to fast food places or restaurants, for that matter, as the portions are huge. Sick of the excuses, though. Type 2 diabetes from being overweight is going to break the bank in the healthcare system and, if the overweight are putting forth so much effort, why has the 'average' US female gone up to 165 lbs @ 5'4"?

      October 29, 2010 at 14:31 | Report abuse |
    • Improve Concentration

      I too have a rollercoaster weigh – sometimes 10lbs in a week.
      You have to keep certain things consistent like exercise and diet.

      Improve Concentration

      October 30, 2010 at 15:42 | Report abuse |
  5. eastcoast6

    There are doctors in almost every town who currently prescribe a phentermine combination drug. Generics are everywhere. Vivus gets credit for at least trying to be in copliance with US safety requirements.

    October 29, 2010 at 10:58 | Report abuse | Reply
    • eastcoast6

      Oops. You know I mean "compliance".

      October 29, 2010 at 10:59 | Report abuse |
    • drew

      And topamax does work to help people lost weight and doctors prescribe it for that use all of the time (off-label).

      October 29, 2010 at 11:55 | Report abuse |
    • TJ


      It's also a drug with nasty side effects and really should not be used only for weight loss. Any doctor prescribing it only for that purpose should lose his license.

      Most neurologists use it as a last resort for migraine treatment. It's THAT bad.

      October 29, 2010 at 15:41 | Report abuse |
  6. Phil

    Shocking. Te FDA is out to
    Protect te big money makers. This drug will be approved in every country but the US

    October 29, 2010 at 10:59 | Report abuse | Reply
    • jillebeans

      wrong!!! Canada has much more stringent checks and balances than the U.S. so I can guarantee it won't be approved in Canada.

      October 29, 2010 at 14:19 | Report abuse |
    • Improve Concentration

      Thank god the FDA finally rejects something.

      Improve Concentration

      October 30, 2010 at 15:42 | Report abuse |
  7. Kate

    People need to stop looking for a magic bullet for weight loss and just get in the gym. People think they can be lazy and lose weight but it's not gonna happen. http://Www.diet-myths.com has some good ways to knock off some pounds.

    October 29, 2010 at 11:05 | Report abuse | Reply
    • drew

      There was a study released recently that shows working out has very little impact on weight control almost 90% less than how people eat. So you can work out at the gym for 8 hours a day and it has less of an effect than eating 200 less calories per day.

      October 29, 2010 at 11:56 | Report abuse |
    • Brenda

      Sorry... but no one who goes to the gym for 8 hours a day is obese! Next excuse?

      October 29, 2010 at 12:37 | Report abuse |
    • Kelly

      Absolutely! The combination of healthy eating, sensible portions, and REAL exercise is the only thing that works. I read that "study" about exercising have little to no effect on weight loss. It's a crock. It's nothing but pandering to a lazy populace that wants to be told it's ok to sit on your butt and do nothing. This site has a ton of great advice on healthy eating (I refuse to call it a diet, because going on a diet implies going off it at some point – healthy eating is for life), including some great recipes and exercise: http://www.doitthehardway

      BTW, try P90X for 90 days and come back and tell me that exercise doesn't cause weight loss!

      October 29, 2010 at 12:43 | Report abuse |
    • Improve Concentration

      Diet is by far the most effective way to control health

      Improve Concentration

      October 30, 2010 at 15:44 | Report abuse |
  8. Kenny

    Thats because the FDA is afraid that the diet drug might actually work. Do you know how much money the FDA and other drug makers will lose when people actually becomes thin and fit? No more profits from selling drugs to "control" diabetes, strokes, heart disease, heart attacks and other diseases stemming from obesity. Of course they will never let that happen. It would be too much lost of revenues for big drug companies. When that happens, the big pharm companies will stop stuffing cash into the FDA's pockets.

    October 29, 2010 at 11:10 | Report abuse | Reply
    • Please Read

      The FDA doesnt make drugs, they regulate them.

      Besides, your point is mute. There are a lot of people who are not obese who have the same problems you mention, and there are even more obese people who do not have those problems. Other medications will not go away. The company that makes an approved weight loss drug will make billions of dollars because of the market for them.

      October 29, 2010 at 11:28 | Report abuse |
    • Joe

      To Please Read:

      I think you mean "moot".

      October 29, 2010 at 11:36 | Report abuse |
    • Kenny

      Yes, I know they don't make drugs. I'm saying they are the approvers of the drugs.

      October 29, 2010 at 12:32 | Report abuse |
    • @ Kenny

      What an unbelievably ingnorant comment...you clearly know nothing about the FDA and it's relationship with industry.

      October 29, 2010 at 12:42 | Report abuse |
    • Mark

      I love reading posts as naive as yours, Kenny. If you feel drug companies and the FDA are so bad, I'm expecting that you have removed all medications from your house and will never again use a single drug. Can you admit that???
      Drug companies are like law enforcement; everyone loves to complain about them until you need them.

      October 29, 2010 at 16:06 | Report abuse |
    • Improve Concentration

      Im not sure about this comment

      Improve Concentration

      October 30, 2010 at 15:46 | Report abuse |
  9. KellerDave

    The only way to cure obesity, especially for those of us who do not respond well to diet and exercise, is to determine the genetic defect that causes obesity and correct it.

    October 29, 2010 at 11:11 | Report abuse | Reply
    • Steve

      Obesity is not the result of genetics...it is 100% do to lifestyle. It is time people take responsibility for their actions and accept the fact that they are fat because of their lifestyle choices. I spent time in africa and did not see one single fat person. In america the vast majority of people are fat. Now do you think people here have different genetics....or they eat more junk food and exercise less? A pill is never the answer......

      October 29, 2010 at 11:32 | Report abuse |
    • Wow

      Dave, sounds like you are making a great excuse for why you shouldn't have to exercise or eat right.

      October 29, 2010 at 12:43 | Report abuse |
    • dt

      If we weren't in the U.S., I would read that like sarcastic humor. Obesity is no more genetic than a stubbed toe. The reason you don't respond well to diet and exercise, is because you haven't done it yet. You may think you have, but you haven't.

      October 29, 2010 at 12:51 | Report abuse |
    • Improve Concentration

      Bull everyone responds to diet and exercise – just look at those people from biggest loser – they all claim generations of obesity, family history, and having tried everything.

      All it really takes is motivation.

      Improve Concentration

      October 30, 2010 at 15:49 | Report abuse |
  10. Amber

    Hey jackass, obesity doesn't just come from over eating. although in a lot of cases this may be the cause in some situations it from not eating enough. There are also situations where the person suffers from a medical problem that prevents them from losing weight. Such as PCOS so before you judge you need to know the root cause.

    October 29, 2010 at 11:20 | Report abuse | Reply
  11. Lenny

    We should send fat people to camps, where they will exercise every day by running away from a pack of hungry velociraptors.

    October 29, 2010 at 11:23 | Report abuse | Reply
    • drew

      People can lose weight, but you will never be any smarter.

      October 29, 2010 at 11:57 | Report abuse |
    • Improve Concentration

      I have to agree there are other ways of being healthy than taking drugs or waiting for some magic pill

      Improve Concentration

      October 30, 2010 at 15:51 | Report abuse |
  12. Steve

    Obesity is not the result of genetics...it is 100% do to lifestyle. It is time people take responsibility for their actions and accept the fact that they are fat because of their lifestyle choices. I spent time in africa and did not see one single fat person. In america the vast majority of people are fat. Now do you think people here have different genetics....or they eat more junk food and exercise less? I pill is never the answer......

    October 29, 2010 at 11:31 | Report abuse | Reply
    • themexcellentone


      You've never heard of epigenetics, then, have you? There are many conditions and diseases that are the result of epigenetic controls.

      As for obesity not being genetic, I eat healthy, exercise and am still overweight. How do you account for that then?

      October 29, 2010 at 11:51 | Report abuse |
    • Drag

      Because you're eating TOO MUCH healthy food. Reduce your caloric intake.

      October 29, 2010 at 12:22 | Report abuse |
    • Anafiel


      Account for your fat? Easy. Too many calories. Wrong type of calories. Fat a** glued to your computer chair. This is NOT rocket science here.... You CANNOT absorb calories out of thin (no pun intended) air. You put it in your mouth, it shows up in your butt. Simple. No other explanation possible. Einstein's modified Conservation of Energy law explains that. You can't create something out of nothing.

      No calories, no fat.
      Get it.
      Accept it.

      October 29, 2010 at 12:28 | Report abuse |
    • Jackie

      Anafiel are you advocating Anorexia saying no calories no fat? It did just occur to me Ana is a part of your screename, and Ana has been used as a nickname for Anorexia.

      October 29, 2010 at 15:01 | Report abuse |
    • TJ


      Uh no. Increase your exercise level so that it at least matches your caloric intake. Then, if that doesn't work, gradually reduce your caloric intake. Do not dramatically drop off your caloric intake. You will kill your metabolism which is much, much worse. Do not put your body into fasting mode.

      October 29, 2010 at 15:44 | Report abuse |
    • TJ


      So no fat soluble vitamins then? At all. Great. Please try not to give advice if you're an idiot.

      Thank you

      October 29, 2010 at 15:45 | Report abuse |
    • Improve Concentration


      I have heard or pre-dispositions to certain things based on genetics but obesity is directly lifestyle related.

      Improve Concentration

      October 30, 2010 at 15:52 | Report abuse |
  13. Mandura Trim

    Weight loss CAN be simple:
    Eat less of healthier foods.
    Get up and move.
    That being said, supplements can help people get over the 'hump' in weight loss -but why does everyone keep looking for the next new, best, silver-bullet drug? Safe Clinically proven drugs like Mandura's TRIM work with the body to help you loose naturally.

    October 29, 2010 at 11:31 | Report abuse | Reply
  14. @Amber

    @Amber, YES, obesity IS coming from over eating.
    You have never seen any obsessed person in any concentration camp pictures now do you?
    So, no more stuffing your face equal to no obesity, no overweight .
    I am not advocating putting people in concentration camp. All I am saying is stop using excuses like medical condition/ genetic/ whatever excuses you got and just reduce your intake then it will reduce your weight PERIOD!!!!.duhhh.

    October 29, 2010 at 11:35 | Report abuse | Reply
  15. the truth

    listen up fatties, you want the cure for obesity? P90X

    steal it, download it, or buy it. watch it and do it.

    October 29, 2010 at 11:38 | Report abuse | Reply
    • cp

      PX90 will not work for extremely obese people, it might even kill them. You can't go from couch potato, barely able to do a flight of stairs to PX90... at least not without a heart attack in the first 5 minutes! I reccommend starting slow, like maybe Wii Fit or going for a walk once a day. Once they can do flight of stairs without huffing and puffing, PX90 is the way to go!!!!

      October 29, 2010 at 13:47 | Report abuse |
    • Jackie

      Cp most of the haters on this board would be glad to have one less "fatty" to burden their sight. I think the above poster is spamming in hopes of making money off their product.

      October 29, 2010 at 15:18 | Report abuse |
    • Improve Concentration

      The truth speaks.

      Improve Concentration

      October 30, 2010 at 16:03 | Report abuse |
  16. Karen

    Using weight loss pills aren't the solution. If you want to lose weight, you need to know how the fat metabolism is working. Mind you, this is knowledge most of the physicians, medical specialists and dietitians are lacking. These posts http://bit.ly/9bFxBU will enable you to figure out yourself which measures you have to take to control your body fat.

    October 29, 2010 at 11:39 | Report abuse | Reply
  17. What a Bunch of

    DAs....I read alot of posts just to waste time, but amazing how alot here just dont get it, and besides that they dont get it, they show everybody how much of a DA and pricks they really are.

    October 29, 2010 at 11:50 | Report abuse | Reply
    • eeyore

      Hey, What a Bunch, "alot" isn't a word. Get spell-check, ya boob.

      October 29, 2010 at 19:55 | Report abuse |
  18. Another Weight Loss Drug

    It's called NoPizzaNexa – certain to be approved by the FDA!

    October 29, 2010 at 11:55 | Report abuse | Reply
  19. Anafiel


    If you don't take in the calories, you can't get fat. PERIOD! Even with metabolic problems, you can lose weight by reducing calories. Conservation of energy law applies here, just like in the rest of the universe.

    October 29, 2010 at 11:56 | Report abuse | Reply
    • TJ


      I'm curious, did you even take biology, anatomy and physiology in high school or maybe college? Because you don't seem to understand how the human body responds to caloric intake and the falloff of such. Nor do you seem to understand how or where the human body gets certain nutrients. Your knowledge on diseases is, well, non-existent and yet you seem... so sure you're right.

      So here's a primer, you can't drop off calories and expect to lose weight. No responsible nutritionist would advocate such a diet. It sends the body into a fasting mode where it conserves resources such that the body expends less energy thus burning fewer calories than if a person were actually consuming MORE calories each day. The better course of action is a healthier diet with more exercise but if that is not possible then dropping a smaller number a calories is better. But seriously, sending someone on a crash diet with no fat is just plain dangerous. Next time, look up just exactly where you get your fat soluble vitamins and what they do for you.

      October 29, 2010 at 16:02 | Report abuse |
  20. wasds

    i dont care what your excuses are. You CANNOT gain weight without overeating

    October 29, 2010 at 12:04 | Report abuse | Reply
    • lisa

      Actually you can gain weight without overeating – it's called pregnancy. Many women have a hard time getting that weight off, myself included

      October 29, 2010 at 12:22 | Report abuse |
    • Brenda

      Lisa... hormones will only take you so far. After a baby the hormones take about a year or so to balance... but you can still cut way back in the meantime and exercise. If you're still very obese after 3 years of pregnancy... either you have a serious medical issue or YOU ARE over eating.

      October 29, 2010 at 12:39 | Report abuse |
    • Kam

      As someone with PCOS, and insulin resistance (both of which took long to diagnose because I am in my normal weight range) you don't just lose weight by not overeating. If ate the way according the US food pyramid I would GAIN weight because it is so carb heavy.

      I bet there are couple of people right now reading this wondering why they're not losing much when they're doing all the right things without knowing they're sabotaging their weight loss with carbohydrates. The Standard American diet is just to carb (sugar) heavy. Even your "healthy" whole wheat bread and granola bars are loaded with SUGAR. If I ate ONE slice of that whole grain bread for breakfast every day I'd never lose weight.

      I know that most of you come from an age where you were taught people gain weight because they overeat, but science has come farther than that.

      October 29, 2010 at 13:00 | Report abuse |
    • Valerie

      Really Lisa? Another woman using that lame old excuse.

      I have THREE kids, and stand 5'10", 140 lbs of muscle and healthy female body fat....it CAN be done, but not on the couch!

      October 29, 2010 at 15:49 | Report abuse |
  21. r3conRanger

    Amber, my guess is that you are overweight. You also have no concept of what 'overeating' is. I would love to look at your complete diet; that is, the average number of calories you consume over an extended period of time derived from protein, saccharides (carbohydrates), and fat combined with your vitamin and mineral intake and the associated expenditures of each. Drop the defense. It IS your lifestyle no matter how you think otherwise. Or I suppose that, like what most overweight Americans love to believe, you are a complete physiological and metabolic anomaly vastly different than the hundreds of generations of humans that have preceded you. A vast majority of the adult problems that lead to being fat (slow metabolic rate, insulin insensitivity, diabetes, hormonal problems, etc.) can be attributed to the diet leading up to that point. But you will still try to counter and attempt to convince everyone that there is 'something really wrong with you' and it's not your fault. The sympathy card is the trump play of the uneducated ignorant.

    October 29, 2010 at 12:07 | Report abuse | Reply
  22. @Amber2

    The primary cause of PCOS is being overweight or obese, not sure you can blame obesity on obesity.

    October 29, 2010 at 12:11 | Report abuse | Reply
    • TJ

      No. It's not. Are you completely unable to google or are you just stupid? It's caused by hormones and often runs in families. The name of the disease is Polycystic Ovarian Syndrome and as someone who is at a normal BMI ( on topamax and thus THIN) and who has it, I can tell you it is not caused by obesity. It is the OTHER way around. No, go sit down and shut up.

      October 29, 2010 at 15:38 | Report abuse |
    • weight loss doc

      Actually, PCOS is caused by weight gain, and goes away when you lose weight in most, but not all cases.

      October 30, 2010 at 12:04 | Report abuse |
    • PCOS

      No, that is untrue! PCOS is NOT caused by being overweight however your symptoms can get worse the more you weigh but it is a double edge sword because the more you weigh, the worse your symptoms are which include being able to lose weight. If I were you I would refrain from making comments like that when you clearly don't understand this syndrome at all. And by the way there is NO CURE FOR PCOS! You learn to live with it- it sucks but that’s life.

      November 3, 2010 at 15:44 | Report abuse |
  23. WW

    I take topiramate on a daily basis to control migraines; a side effect has been a lessening of my "desire for food", it's that I just don't particularly care whether I eat or not. Perhaps that is the trigger that contributes to the weight loss. I have had no other side effects to taking the medicine.

    October 29, 2010 at 12:16 | Report abuse | Reply
  24. kc

    I hate to say it, but obesity comes from over eating. I am obese and have PCOS and I have lost 40 pounds by guess what? Eating less and working out five days a week. Put down the beer and donuts and put on some shoes and go for a walk.

    October 29, 2010 at 12:16 | Report abuse | Reply
  25. Y'all don't get it

    I have reduced my intake to 1400 calories a day according to a balanced diet by my dietician. I work out an hour a day five days a week with cardio/weights. I take my metformin for my PCOS and I'm still the same weight – a little leaner, but I can't lose the weight even after a partial hysterectomy. Add to that a Chiari Malformation that hurts even after decompression and I'm DOING THE BEST I CAN. Sorry I can't be what the medical books want me to be, but I'm trying my HARDEST to be the healthiest I can be in all areas of my life.

    October 29, 2010 at 12:22 | Report abuse | Reply
    • Brenda

      Cut back to 1200 calories a day then.

      October 29, 2010 at 12:40 | Report abuse |
    • Kate

      Seriously Brenda...she should cut back more?? Not likely in her scenario. There is no cookie cutter solution to weight loss, so stop making recommendations that may not be accurate.

      October 29, 2010 at 13:36 | Report abuse |
  26. maria miller

    I take Topamax daily. It took 3 tries before I could handle it on a daily basis. I take it to prevent migraines. I had daily cluster migraines that no meds would help. So It works great and keeps almost all migraines away. But the side effects are HORRIBLE. Will you lose weight??? YES...At first You'll lose up to 10-12 pounds. It doesn't matter what you eat it just falls off, plus there's a huge loss of appetite. But then that's it. It Stops. No further loss. If you go off the drug you'll start to gain it back, And if you go off and then get back on after awhile. You never again get that weight loss effect like you did at first. But with it comes. Huge vision loss went from -5.75 to to a -7.00, Vision blurriness, Electric shock pains in your feet, All carbonated drinks taste horrible (gets better with time) But the worst thing is it makes you Retarded!!! Lots of brain fogginess and short term memory loss. Sometimes when you fill out paperwork you cant remember your address, or phone number, or age. Your always at a loss for words. Its like your life is the game password. I'll say to my husband. Can you get me a uhh you know. the thing you eat with....." I know what I want, I see a pic of it in my head, So I just describe it and he'll say "fork?" and I'll say yes thats it. That happens all the times. Sometimes your just blank and stare at the wall for awhile and don't realize it. What a scary drug for the masses to take who want a miracle cure to lose weight. 1/3 we eat too much with no exercise, 1/3 there's all this crap and chemicals in the food that make us fat, 1/3 metabolism/genetics You got a good one or you don't. My husband couldn't gain weight if he tried. Some people look at a cheesecake at get fat. But Watch the tv show biggest loser, anyone can lose weight with just diet and exercise. It just sucks and it's hard......It would be nice to have a pill that could help. But this combo would not be good. Topomax is hard enough for before who medically need it. Add a meth-speed like substance to it.....It would be a disaster.

    October 29, 2010 at 12:23 | Report abuse | Reply
    • Rayven

      I was on Topamax myself for migraines and it made me crazy! I did loose a lot of weight to the point it started consurning my parents and my mood swings were out of this world. I physically faught both my parents. I was just not myself on that medication. Once I stopped my weight increased and battled with my weight for several years until this year. I finally got my mind right and lost 37pounds and 38 more pounds to lose by working out 6 days a week and eating a clean diet. I know longer have migraines THANK THE LORD. But I agree no diet pill or surgery in my eyes will help you lose the weight in a safe and health way. It has to be a complete lifestyle change.

      October 29, 2010 at 12:57 | Report abuse |
    • dt

      That drug sounds great. You said what I always say about the tv show the biggest loser. They take the biggest, fattest, excuse making people, and feed em lettuce and put em on the treadmill. Guess what? The genetics NEVER WIN!!!! LOL.

      October 29, 2010 at 12:58 | Report abuse |
    • mk

      I know some drugs are necessary, but wow, the way a drug can alter your mind...that is seriously scary and why I'll do anything to avoid taking medicine.

      October 29, 2010 at 13:39 | Report abuse |
    • RebeccaS

      "Its like your life is the game password. I'll say to my husband. Can you get me a uhh you know. the thing you eat with....." I know what I want, I see a pic of it in my head, So I just describe it and he'll say "fork?" and I'll say yes thats it. "

      YES! That's exactly what it was like when I was on Topamax, too. My husband thought it was amusing, but I just found it frustrating. The inability to communicate clearly, and constantly forgetting the simplest things - it drove me nuts.

      And I hate to say it, but once I went off the drug, the problems didn't fully go away. It's a lot better than it was, but I still run into the memory issues enough for it to be noticeable. I had a great vocabulary, and was a pretty good write and communicator before I went on Topamax; now, I feel like I'm at the remedial level all the time 🙁

      October 29, 2010 at 13:42 | Report abuse |
    • TJ

      I've been taking Topamax for migraines for over 5 years and I agree, the cognitive side effects are absolutely horrible. I'm a program manager and I can't do simple math without relying on a calculator. I should be brushing up on my skills by taking continuing education but my neurologist says not to bother as it would be a waste of money. At let's forget even attempting to write anything coherent. It's a lost cause.

      I've gotten better about mitigating some of the side effects such as aphasia and I've been able to go back to reading (I wasn't able to concentrate long enough to read a book for years) but other things are still too much i.e. I still can't trust my self to drive a car.

      My neurologist has been trying to move me to other medications for a couple years but sadly, everything else has failed and going off the medication is always a nightmare.

      I honestly can't imagine someone wanting to take a drug like this to lose weight. If there was any other drug that worked as well to control my migraines, I'dtake it.

      As for weight loss, well, yeah it works on a number of levels but it certainly doesn't make eating anything other than a chore. Food for the most part tastes terrible. Soda is awful (that's good). You can't risk drinking alcohol – no loss but it makes for awkward situations. Processed foods taste like cardboard. You can only tolerate a little food at a time. So yeah, I guess it's a weight loss drug if you want to lose all incentive to eat and pretty much become anorexic and deal with embarrassing, awkward social situations.

      October 29, 2010 at 15:16 | Report abuse |
    • TJ

      "At let's forget even attempting to write anything coherent. It's a lost cause. "

      Should be "And let's forget"

      see what I mean?

      October 29, 2010 at 15:18 | Report abuse |
  27. Drag

    Haha my wifes step-mom uses the "genetics" excuse for being a fat blob. Yet she was super skinny in high school, and her mom and dad were very heavy for a while. Now here's the funny part, her mom and dad lost a bunch of weight, and look amazing, and she's still a fat ass, because she's the type of person who goes out to a mexican restaurant and thinks eating a TACO SALAD is healthy.. Those things have like 2000 calories in them! That's a FULL days worth of calories!

    People, cut the crap. No more excuses, I know it's hard, but stop eating so much. And watch what you eat, some foods have the same mentally addictive effect as cocaine. They release endorphins in your brain that make you feel happy when you eat, and make you crave the foods when you're not eating them.

    October 29, 2010 at 12:26 | Report abuse | Reply
  28. Kenny

    Bingo. Everyone who is overweight wants to lose the weight by some magic pill or a routine where they only have to do 5 minutes of exercise a day. Not gonna happen. You wanna lose weight? Take a serious look at your diet and pick up a basic book on nutrition. Commit yourself to a real exercise routine. This isn't an unsolvable problem, but the solution takes work and unfortunately there are a lot of lazy people out there that would sooner look and feel like terrible than actually have to work for their own health.

    October 29, 2010 at 12:30 | Report abuse | Reply
  29. Brenda

    Most cases DO come from OVER eating and NOT exercising.

    October 29, 2010 at 12:31 | Report abuse | Reply
  30. Junior

    Obesity, alcoholism, smoking, ADD, and many other so-called diseases can be cured by simply exercising some self-control. There is no reason for insurance or government to waste money on this nonsense. Use the money on people who have real diseases and let the others live with the consequences of their bad choices!

    October 29, 2010 at 12:32 | Report abuse | Reply
    • Jay

      Taking a pill is so much easier than self-control. And you can't call the kid a little monster or the parents irresponsible if they get their kid a diagnosis.

      October 29, 2010 at 15:39 | Report abuse |
    • TJ


      Just so you know, they didn't "research" this as a weight loss drug. It was discovered as a side effect and then they went forward to seek approval. Drugs like this were developed for other disorders. That's how they moved forward with Topamax as a potential weight loss drug. It was a drug for epilepsy/migraine and then they tried to market it for weight loss which was insane and crazy.

      Anyone who has ever taken Topamax in any significant dosage can tell you that. It's like taking crack cocaine.

      October 29, 2010 at 17:08 | Report abuse |
    • Teachermom

      ADD/ADHD is actually a real disorder. There is finally REAL scientific evidence to back that up. ADD/ADHD brains are different. I would not classify it as a disease, but it is a disorder that really does exist. It may exist in such abundance these days as a result of all the crap we put into our bodies and all the crap that is in the environment, and I may have (unknowingly) altered both of my children in utero... who knows? I do believe that in many cases medication can be rendered unecessary by a diet free from certain elements; however, even if the ADD/ADHD is controlled- it is STILL in there in the brain- it doesn't simply disappear. Anyway, as a teacher for more than 10 years I have seen enough to know that it IS real. As a mom with 2 kids who have been diagnosed by a behavioral disorder expert as well as the pediatrician, I can tell you that it IS something real that self-control has nothing to do with. So, please do not lump it in with alcoholism or smoking for crying out loud. Quitting smoking blows. Starting to smoke was a choice. Stopping alcohol intake = tough, tough, tough. Drinking was a choice at one point. My children and the students I have taught in the past did not have a choice in their ADD/ADHD diagnosis. And, no, I don't throw medication at my children because I want them to be zombies... When your 8 year old daughter asks you if she is stupid because it takes her so long to answer her math board work when everyone else is finished, and you say that of course she isn't... and she tells you that the kids at school all say she is dumb and that she is the dumbest in her class... You'll know that there is NOT a comparison between that and nicotine addiction. And, when that same 8 year old girl begins to be treated for her ADD/ADHD and she scores a 36/36 on her math TAKS (standard. test) You'll know as a parent that you did the RIGHT thing. Smoking and drinking are NOT the same as an ADD/ADHD diagnosis. It is real. It exists. It was NEVER and will never be a choice. Good grief.

      October 29, 2010 at 17:31 | Report abuse |
  31. Sarah

    I think we are fat because we sit in front of a computer all day. I feel so much better on the weekends when I can clean house, do yard work etc. I used to clean houses and was quite fit, and now I'm getting mushy sitting in at this desk all day. Excuse me while I go get some ice cream and eat my feelings.

    October 29, 2010 at 12:33 | Report abuse | Reply
  32. SusieQ

    Diet drugs are not the answer – changing behavior is and always has been how to lose weight. Period. Drugs and miracle diets only provide short-term solutions. It takes willpower to change, but it is possible if someone really wants to. And it needs to be because YOU want to, not because someone else says you should. Eat healthy and get up and move! And eat 3 healthy meals; skipping a meal or two only slows metabolism. I am pretty tired of hearing nothing but excuses for people being overweight.

    October 29, 2010 at 12:33 | Report abuse | Reply
  33. naturesfoodneedstobecheaper

    i am overweight, and i know why, pizza, wings and soda and a lack of exercise...done...not making any excuses but what i do have to say is this....i think a large part of the problem is the cost of healthy foods...every time i see a show or read something about losing weight, it involves a "colorful" plate meaning fruits and veggies...to feed a family, fruits and veggies are expensive!!!! anyone seen the movie "food inc"...the perfect scenario was in tht movie, a family can feed their kids for a dollar and get a double cheesburger which will keep the full alot longer than an apple...the kids wanted fruits but at $1*29 a pound, its too expensive for some people and doesnt hold over long....in the past, i had lived on food stamps when my son was first born, if i hadnt had those, my son wouldnt have had access to as many healthy foods, thank god i did..hes a lean, health, happy kid....i not trying to make excuses, but i feel as a nation, we need to make the healthy foods more accessable to all lifestyles..

    October 29, 2010 at 12:33 | Report abuse | Reply
    • Sebastian

      Here are some revolutionary ideas:
      1. Don't have kids you can't afford
      2. Realize that you choose your priorities; food is not expensive here, you just choose to spend less on it. Maybe if you cut your calbe, internet, actually shopped smart – I bet I could make a family of 4 a meal for the cost of you taking yourself and your son to McD's

      October 29, 2010 at 13:31 | Report abuse |
    • Alison

      You should try and find a farmers market near your home. The one near me, I can literally no joke, fill a huge cart up with fruits, veggies, and the bill comes to $40 max.5 cucumbers for $1, a quart of strawberries for $1.99, its crazy cheap and tasty too! If I tried it at Publix or WinnDixie it would easily be triple that. It's really saved us (as a family of 3) a lot of money, b/c we can't afford to shop at Whole Foods or health food stores. Just a thought 🙂

      October 29, 2010 at 13:50 | Report abuse |
  34. Jopa

    Im a graduate student in nutritional sciences. While excercise may help, you really have to engage in high intensity exercise (over an hour 5 times a week) to see weight changes because the body simply compensates for physical activity by increasing appetite through ghrelin and other GI neuropeptides. These peptides signal hunger in the hypothalamus in very eligant ways. Its fairly simple that excess calories, which you get from fat, carbohydrates, proteins, and ethanol each have energy stored in their bonds. By consuming them at a faster rate than you burn them, our bodies are smart enough to store them. For some reason in our evolutionary deveoplment, mother nature never gave us a great reason to adapt to over eating, just starvation.

    October 29, 2010 at 12:37 | Report abuse | Reply
  35. Sarah

    If you drink a diet coke with a snickers they will cancel each other out and it's like you ate nothing at all.

    October 29, 2010 at 12:39 | Report abuse | Reply
    • Jopa

      you still have to metabolize the calories you ate from the snickers, and have to deal with the insulin secretion the glucose causes. albeit the insulin spike is less since you're also not consuming sugars in the diet coke/pepsi. there are really no healthy foods or unhealthy foods, its really about portion size. We like to feel full, we dont like to sit in traffic, etc. sometimes controlling urges really does pay off. Part of a healthy life style is cognition in portion size, not just food selection.

      October 29, 2010 at 12:43 | Report abuse |
    • dt

      Jopa: Preeeetty sure the above comment is sarcasm.

      October 29, 2010 at 13:03 | Report abuse |
    • Jopa

      yeah.. you're probably right. I had too much coffee this morning.

      October 29, 2010 at 13:05 | Report abuse |
    • cp

      hahahahaha that's great! How about sticking both of them to your butt instead? That's my theory. Instead of eating something I know is not good, I just comment about sticking it to my butt. People laugh but it makes them think twice about eating it too!

      October 29, 2010 at 13:51 | Report abuse |
  36. RealTarikTyler

    Good. the last thing we need is another quick fix. After 25 years of working in the fitness industry the answer keeps coming back the same.
    Eliminate or restrict your consumption of processed foods.
    Eat more fruits and vegetables on a daily basis.
    Increase the amount of resistance training you do to add more lean muscle mass and boost your metabolism.
    Do interval cardio at least 4 times per week.
    Drink at least 70 ounces of water a day
    more can be found at my website http://www.tariktyler.com

    October 29, 2010 at 12:42 | Report abuse | Reply
    • Exactly

      That's what I did, and now a year out of law school I'm in better shape than I've been since highschool. It was HARD. I gave up all sodas/suger drinks and now water is 99% of what I drink. I completely changed my eating habits. I exercise 6 times a week ranging from an hour to a hour and a half a day.

      Stuff was ridulously difficult at first, but you know what? Now it's routine. It's easy. If I eat some greasy fast food now I have an immediate and realy physical reaction to it.

      I'm convinced most people can do this too. Just takes the committment

      October 29, 2010 at 12:52 | Report abuse |
  37. Mark H

    Why don't alcoholics just stop drinking? Or gambling addicts just stop placing that bet? What about people addicted to sex (I won't use the term sexaholic, that's just weird), why don't they just get into committed relationships?

    It's all about the inability to control some kind of addictive behavior. My drug is food. I eat when I'm bored, when I'm sad or depressed, I eat to pass time or to be more social with friends. I clean my plate, no matter how much is piled on it, because that's what I was taught would make me (and to a small part the person who filled the plate) happy. Yes, I can loose weight if I just stop eating so much. I just wish I could.

    October 29, 2010 at 12:43 | Report abuse | Reply
    • Sebastian

      I can't believe you went there – sex addiction lol. HAHAHA maybe you should watch some southpark.

      October 29, 2010 at 13:33 | Report abuse |
  38. Sarah

    Pork Chops are good.

    October 29, 2010 at 12:44 | Report abuse | Reply
  39. Tyler

    I hate when people blame obesity entirely on over-eating. The people who do typically have no experience at all with the problem. Sure, there are quite a few people who's only problem is over-eating. Also, have you ever thought that biologically that one's ability to control how much they eat is different than your own. Using weight medicine temporarily is a decent way to incourage a better diet and excercise schedule. It is like using a nicotine patch to help break an addiction.

    I used a weight loss drug for about six months on two separate occassions. I lost quite a bit of weight and gained a bit back afterwards but am starting to lose again BECAUSE of the routines I was able to put in place with the pill originally.

    October 29, 2010 at 12:53 | Report abuse | Reply
  40. Limbaugh is a liberal

    Vivus didn't pay enough bribe money to FDA officials?

    October 29, 2010 at 12:53 | Report abuse | Reply
  41. erewenguy

    The relatively benign CRL for Qnexa is not really surprising. VVUS is an FDA/Wall St./media darling.

    David Orloff had been promoting the concept of combination therapies since at least 2004 while he was still at the FDA. When he suddenly resigned from the FDA in the middle of controversy over questionable drug approvals in his office, he was fortunate to get a job at Medpace.

    While at Medpace, Dr. Orloff oversaw clinical trials of Qnexa and “crafted” the Qnexa NDA, which was reviewed at the FDA by Eric Colman, the person who Orloff had supervised and worked closely with while at the FDA.

    The fact that Qnexa does not meet the requirements for combination therapies based on the component efficacies does not matter. The fact that the advisory committee panel requested additional clinical trials for cardiovascular concerns does not matter. The fact that topiramate causes cognitive problems and birth defects does not matter.

    This drug was a foregone decision that has been in the works at FDA since at least 2004, where it was discussed by the theraputics subcommittee at the FDA obesity working group.

    An FDA official tainted by scandal, leaving to test a drug already being discussed by FDA, and submitting the application for approval back to the same office where he worked, for review by his former associate, reeks of cronyism.

    Cheers to your good news today VVUS shareholders! Qnexa will be approved soon, but as a citizen I am sadly disappointed in our FDA drug approval process.

    Deal making is a part of life. Que sera sera. This is not the first time a hopefully objective function of government is drenched in cronyism. The outrage one experiences then becomes a function of whether you benefit or suffer from the cronyism.

    The real test of Qnexa will be when it hits the market. The cognitive side effects of topiramate will be more of a problem than birth defects associated with the drug. Confusion and memory loss may be an acceptable price to pay for epileptics when the alternative is seizures, maybe not for obesity treatment.

    Hopefully alternatives will soon available to treat obesity without the very real mental confusion known to be caused by topiramate, and also shown to occur during Qnexa clinical trials.

    October 29, 2010 at 12:55 | Report abuse | Reply
  42. MkeOND

    Based on side effects , I can hypothesize that this medication will make your mind slow and damage your brain longterm....but of course there are slew of other meds that patient take also that may cause brain damage.

    October 29, 2010 at 12:56 | Report abuse | Reply
  43. livekdhhwy12

    i just wish they would bring back ephedrine. Who cares about the wrestlers and baseball players who die from abusing it. Its a risk you are willing to take. I lost 60 pounds over Christmas break after my freshman year of college football. Needless to say i quit football and started focussing on the more important things in life.. like taggin every hottie i could (which is the ultimate exercise!)

    October 29, 2010 at 12:58 | Report abuse | Reply
  44. Bob

    The FDA refused to approve a drug! Wow!! Must be really dangerous!

    October 29, 2010 at 13:00 | Report abuse | Reply
  45. pjpflyers2

    I know, I know.....it's a gland problem.

    October 29, 2010 at 13:03 | Report abuse | Reply
  46. SammyD

    I've been reading alot of these comments and man, it is a shame how many ignorant verbally bullies there are!

    Stop poking fun at people that have a problem just like most addicts do and for some it's food!

    I didn't realize you were all experts, doctors, nutritionists etc.....you are not settugn good examples either! Calling people fatties, fatblobs, fat asses etc. YOU are all what's wrong with America, in a time when bullying has become such a big problem!

    October 29, 2010 at 13:05 | Report abuse | Reply
    • Sebastian

      I'm not fat; I'm just big bonned!

      October 29, 2010 at 13:36 | Report abuse |
    • Sarah

      "I eat because I'm fat and I'm fat because I eat"

      October 29, 2010 at 13:51 | Report abuse |
  47. Rikki83

    You know, I find it funny that people automatically jump to the over-eating conclusion when they see someone's that overweight. I grew up with two obese parents, and they didn't eat any more (or less) than my scrawny butt did. There are a lot of factors that go into obesity – age, metabolism, how much you eat for the type of metabolism you have, state of mind (depression etc...), genetics...

    As you get older your metabolism slows down – that's something we learn while we're still in school. But while some people naturally have a high metabolism, others also have a slow metabolism. Yet, even with a high metabolism as you age, it begins to slow down and therefore you begin putting on weight, even if you're eating the same way you were before.

    By jumping to the conclusion that over-eating is the ONLY reason people are obese is showing ignorance. Yes, some people are from over-eating but for others, there are different, other factors for the reason of it. It is not only impolite and rude to attack these people because they're obese, but it also shows how heartless the human race (in general) has become.

    October 29, 2010 at 13:07 | Report abuse | Reply
  48. Kristen

    Genetics and certain health conditions can hinder you, but you will be obese and overweight when you overeat. I know because I used to be. I have an underactive thyroid which can make it harder to lose weight but I am proof it can be done. Diet pills and surgery are not the answer. They just damage your organs and can cause you to die. I tried many things. But it ultimately comes down to your determination and getting it in your head to lose the weight. Weight Watchers and working out in a gym 4 to 5 days a week for 45 minutes to an hour is the best way to lose. I know because I have lost 135 pounds following ww plan and exercising. I lost it in a year and a half.. I now weigh 135 lbs and have gotten rid of sleep apnea, high blood pressure, lowered my cholesterol, no swelling ankles, and have so much more energy. Do it the right way by taking in less calories and fat and reducing portion sizes.

    October 29, 2010 at 13:08 | Report abuse | Reply
    • mk

      Good for you Kristen! Proof it can be done...

      October 29, 2010 at 13:36 | Report abuse |
  49. Joe

    I want to explain something to you and please, really absorb it. First of all, you don't understand metabolism. That being said, assume metabolism is the culprit here. If you have a slow metabolism, and eat more than it can handle, and that is what is making you fat, then you are OVEREATING!!!!!!! Can you please realize the Irony of the logic "Its not my fault, Its my metabolism?" Thats like saying "I didnt kick the soccerball, my leg did."

    October 29, 2010 at 13:12 | Report abuse | Reply
    • Joe

      that was for Rikki83

      October 29, 2010 at 13:13 | Report abuse |
  50. laurie

    As a personal trainer, I cannot count the times people told me they had a "pretty clean" eating plan. Its simple math..3500 calories is equal to 1 pound...if you burn or reduce 3500 calories a week you can safely lose 1 pound. It is not just overeating, but what you are eating as well. I have cleaned up my eating and can not really tolerate alot of sugar anymore. I am in better shape now at 49 yrs old than i was in my 20s. And I DID have a baby...and it is hard work..but I did it...as with anything, if you REALLY want it enough, yo will do it.

    October 29, 2010 at 13:14 | Report abuse | Reply
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Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.

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