Smoking boosts risk for Alzheimer's
October 25th, 2010
04:52 PM ET

Smoking boosts risk for Alzheimer's

Here's yet another reason to stop smoking: It elevates the risk of Alzheimer's disease and vascular dementia, according to a new study.

An analysis of more than 20,000 men and women found a 157 percent heightened risk of Alzheimer's disease in people who had smoked more than two packs of cigarettes a day. For vascular dementia, the second most common form of dementia, these smokers had a 172 percent increased risk.

"Dementia is a disease that crops up in late life, and that becomes clinically apparent, but I think people really need to think about risk factors for it over the life course," said Rachel Whitmer, study co-author and research scientist with Kaiser Permanente Division of Research in Oakland, California.

The study, sponsored by Kaiser Permanente, is published in the Archives of Internal Medicine.

Researchers say the association between smoking and various forms of dementia is strong, but they do not know exactly why. It has been shown before that people who smoke are more likely to have hypertension and cerebral vascular disease, as well as inflammation, Whitmer said. Smoking may contribute to the damage of brain blood vessels in addition to brain cells, she said.

The data came from Kaiser Permanente Northern California members surveyed between 1978 and 1985. At that time, they were between ages 50 and 60. Diagnoses of various forms of dementia among these people were made from 1994 to 2008, and researchers took that information from electronic health records. The participants in this study were all alive and still members of the health plan in 1994.

Researchers found that associations with the development of the disease are more modest among smokers who use up fewer than two packs a day, but still significant. Those who smoked a half-pack to one pack a day had an overall 37 percent elevated risk of dementia, and those who smoked between one and two packs had a 44 percent heightened risk, compared to non-smokers.

But this could be an underestimation, because some smokers who would have developed dementia died before diagnosis, said Kenneth Hepburn, associate dean for research at the Emory University School of Nursing, who was not involved in the study.

The reported risk of dementia among heavy smokers is also likely an underestimation because many of those people will die before they're old enough to develop dementia, he said.

While the elevated risk for various forms of dementia was shown for those smoking two packs a day in midlife, smoking less than half a pack of cigarettes a day, or having smoked in the past, did not appear to raise the risk compared with nonsmokers.

Hepburn found the study compelling, and noted that it incorporated an ethnically diverse population of both men and women.

"This gives great confidence in saying this kind of heavy smoking has some kind of association – and it looks like a fairly strong association – with the development of the disease," he said.

One limitation of the study is that researchers collected data only about smoking habits among middle-aged people; it did not look at what happened among those who had quit after the initial survey, Whitmer said.

The research speaks to what the Alzheimer's Association Maintain Your Brain campaign is promoting: that brain health has a lot to do with overall health, Hepburn said.

"The brain is part of the body, it’s part of the whole and if you assault parts, it’s going to have an impact on the whole," he said.

soundoff (2,459 Responses)
  1. leflunomide

    choloquine azathioprine chloroquinolone malaria

    June 5, 2021 at 12:08 | Report abuse | Reply
  2. cialis 20mg

    cost tadalafil generic cialis tadalafil dosage bodybuilding

    June 5, 2021 at 16:45 | Report abuse | Reply
  3. 경주출장

    This is a great tip especially to those new to the blogosphere. Short but very accurate infoÖ Thank you for sharing this one. A must read post!


    June 5, 2021 at 18:14 | Report abuse | Reply
  4. 최상위 파워볼 사이트

    I would like to thank you for the efforts you have put in penning this blog. I'm hoping to check out the same high-grade blog posts by you later on as well. In truth, your creative writing abilities has motivated me to get my own, personal blog now 😉


    June 5, 2021 at 18:22 | Report abuse | Reply
  5. 파워볼 사이트

    I like it when people come together and share thoughts. Great blog, continue the good work!


    June 5, 2021 at 18:33 | Report abuse | Reply
  6. tadalafil drug

    maximpeptide tadalafil price walmart 20mg tadalafil

    June 5, 2021 at 18:38 | Report abuse | Reply
  7. 파워볼 사이트

    bookmarked!!, I really like your website!


    June 5, 2021 at 19:27 | Report abuse | Reply
  8. chloroquine cancer

    hydroxychloroquine sulfate uses quineprox kratom chloroquine hydrocholoroquine

    June 5, 2021 at 19:35 | Report abuse | Reply
  9. chloroquine online

    hydro chloroquine buy chloroquine online is hydroxychloroquine safe to take

    June 5, 2021 at 20:09 | Report abuse | Reply
  10. plaquenil brand name

    anti-malaria drug chloroquine side effects of hydroxychloroquine chloroquine side effects

    June 5, 2021 at 21:08 | Report abuse | Reply
  11. 파워볼사이트

    Excellent article. I will be going through many of these issues as well..


    June 5, 2021 at 21:15 | Report abuse | Reply
  12. hydroxychloroquine studies

    is chloroquine safe didier raoult chloroquinolone malaria

    June 5, 2021 at 22:24 | Report abuse | Reply
  13. 파워볼 전용사이트

    After looking into a handful of the blog posts on your web page, I honestly like your technique of blogging. I saved it to my bookmark website list and will be checking back soon. Please check out my web site too and tell me your opinion.


    June 5, 2021 at 22:24 | Report abuse | Reply
  14. 경주출장마사지

    Howdy! I just want to offer you a huge thumbs up for your great info you have got right here on this post. I will be returning to your blog for more soon.


    June 6, 2021 at 01:26 | Report abuse | Reply
  15. tadalafil blood pressure

    tadalafil 20 tadalafil brands elevex tadalafil 20mg

    June 6, 2021 at 01:39 | Report abuse | Reply
  16. cost tadalafil generic

    prescription tadalafil online tadalafil from canada to usa tadalafil research

    June 6, 2021 at 11:06 | Report abuse | Reply
  17. 최상위 파워볼 사이트

    This page really has all the info I wanted concerning this subject and didnít know who to ask.


    June 6, 2021 at 11:19 | Report abuse | Reply
  18. 파워볼최상위사이트

    I truly love your website.. Great colors & theme. Did you develop this web site yourself? Please reply back as Iím planning to create my own site and want to find out where you got this from or what the theme is named. Cheers!


    June 6, 2021 at 12:57 | Report abuse | Reply
  19. 파워볼 사이트

    This web site definitely has all of the information I wanted concerning this subject and didnít know who to ask.


    June 6, 2021 at 15:16 | Report abuse | Reply
  20. cost tadalafil generic

    over the counter tadalafil tadalafil order online no prescription erectafil 20

    June 6, 2021 at 15:30 | Report abuse | Reply
  21. 파워볼 전용사이트

    Nice post. I learn something totally new and challenging on sites I stumbleupon every day. It's always useful to read through articles from other authors and practice a little something from their websites.


    June 6, 2021 at 15:51 | Report abuse | Reply
  22. 파워볼 사이트

    You're so awesome! I do not believe I've truly read a single thing like that before. So great to discover somebody with genuine thoughts on this subject matter. Seriously.. thanks for starting this up. This website is something that is needed on the web, someone with some originality!


    June 6, 2021 at 18:33 | Report abuse | Reply
  23. 파워볼사이트

    Good post. I learn something totally new and challenging on blogs I stumbleupon on a daily basis. It will always be helpful to read content from other writers and use something from other web sites.


    June 7, 2021 at 00:59 | Report abuse | Reply
  24. 파워볼최상위사이트

    Having read this I thought it was extremely enlightening. I appreciate you taking the time and effort to put this information together. I once again find myself personally spending a significant amount of time both reading and leaving comments. But so what, it was still worth it!


    June 7, 2021 at 03:31 | Report abuse | Reply
  25. 파워볼사이트

    I need to to thank you for this very good read!! I definitely enjoyed every little bit of it. I have you saved as a favorite to check out new stuff you postÖ


    June 7, 2021 at 05:02 | Report abuse | Reply
  26. 파워볼 사이트

    Having read this I thought it was rather enlightening. I appreciate you finding the time and effort to put this short article together. I once again find myself spending a lot of time both reading and posting comments. But so what, it was still worthwhile!


    June 7, 2021 at 05:14 | Report abuse | Reply
  27. 먹튀검증업체

    Great information. Lucky me I ran across your website by chance (stumbleupon). I have saved it for later!


    June 7, 2021 at 07:27 | Report abuse | Reply
  28. 먹튀검증

    Aw, this was a really good post. Spending some time and actual effort to make a really good articleÖ but what can I sayÖ I hesitate a whole lot and never manage to get nearly anything done.


    June 7, 2021 at 08:27 | Report abuse | Reply
  29. chloroquine tablets

    hydroxychloroquine and chloroquine side effects nivaquine what is hydroxychlor 200 mg used for

    June 7, 2021 at 11:32 | Report abuse | Reply
  30. 먹튀검증

    You have made some decent points there. I checked on the internet for additional information about the issue and found most individuals will go along with your views on this website.


    June 7, 2021 at 12:45 | Report abuse | Reply
  31. 먹튀검증

    You ought to take part in a contest for one of the best websites on the web. I most certainly will highly recommend this site!


    June 7, 2021 at 14:15 | Report abuse | Reply
  32. wandavision costume gif

    In the WandaVision ending, a information in the outfit that Wanda puts on as the Scarlet Witch can be connected to the style of her soulmate


    June 7, 2021 at 14:21 | Report abuse | Reply
  33. 청주출장안마

    Greetings! Very helpful advice in this particular article! It is the little changes that will make the greatest changes. Thanks for sharing!


    June 7, 2021 at 19:40 | Report abuse | Reply
  34. raoult coronavirus

    hydroxychloroquine sulfate 200 mg chloroquine malaria hydroxychloroquine sulfate 200mg

    June 7, 2021 at 20:55 | Report abuse | Reply
  35. 부산출장마사지후불

    This is the right web site for anybody who wishes to find out about this topic. You know so much its almost hard to argue with you (not that I really will need toÖHaHa). You certainly put a brand new spin on a topic which has been written about for many years. Great stuff, just excellent!


    June 7, 2021 at 23:52 | Report abuse | Reply
  36. 청주출장안마

    Great article. I will be dealing with many of these issues as well..


    June 8, 2021 at 00:02 | Report abuse | Reply
  37. 청주출장마사지후불

    I'm very happy to discover this website. I need to to thank you for ones time just for this fantastic read!! I definitely savored every part of it and i also have you book marked to check out new stuff in your blog.


    June 8, 2021 at 00:46 | Report abuse | Reply
  38. wandavision comic accurate costume

    New Program WandaVision Agatha Harkness Agatha Cosplay Costume C00483 · New Show WandaVision Scarlet Witch Wanda Ending Cosplay Outfit


    June 8, 2021 at 00:59 | Report abuse | Reply
  39. 부산출장후불

    Saved as a favorite, I love your web site!


    June 8, 2021 at 01:21 | Report abuse | Reply
  40. wanda maximoff halloween costume wandavision

    WandaVision's period finale offered us the first proper consider Wanda's superhero attire.


    June 8, 2021 at 01:45 | Report abuse | Reply
  41. restoran di kota bharu kelantan

    What's up to every single one, it's in fact a fastidious for me to pay
    a visit this site, it includes precious Information.

    June 8, 2021 at 01:56 | Report abuse | Reply
  42. chloroquine malaria prophylaxis

    why is hydroxychloroquine cloroquina is hydroxychloroquine safe to take

    June 8, 2021 at 03:30 | Report abuse | Reply
  43. 부산출장마사지

    bookmarked!!, I love your blog!


    June 8, 2021 at 04:38 | Report abuse | Reply
  44. chloroquine sulfate

    how long has hydroxychloroquine been used arechin hydroxicloroquin

    June 8, 2021 at 07:40 | Report abuse | Reply
  45. chloroquine nz

    what is hcq medicine hydroxychloroquine sulfate corona hydroxychloroquine sul

    June 8, 2021 at 08:46 | Report abuse | Reply
  46. 청주출장마사지후불

    You have made some really good points there. I looked on the net to learn more about the issue and found most individuals will go along with your views on this site.


    June 8, 2021 at 12:44 | Report abuse | Reply
  47. 부산출장

    Everything is very open with a precise description of the issues. It was truly informative. Your website is very useful. Thank you for sharing!


    June 8, 2021 at 16:08 | Report abuse | Reply
  48. 청주출장마사지후불

    This blog was... how do I say it? Relevant!! Finally I've found something which helped me. Appreciate it!


    June 8, 2021 at 16:56 | Report abuse | Reply
  49. tructiephd

    Kết Quả Futsal Việt Nam Vs Lebanonkết quả tennis hôm nayTheo thể thức thi đấu, đội thắng ở cặp đấu này sẽ giành tấm vé đến Lithuania vào ngày hội bóng đá lớn nhất thế giới đến futsal. Tuyển futsal Việt Nam bước vào trận play-off lượt đi tranh vé dự play-off World Cup 2021 với sự tự tin. Tuy vậy, HLV Phạm Minh Giang bày tỏ, toàn đội không ngán Lebanon tuy nhiên sẽ tìm cách để khắc chế sức mạnh của đối thủ bởi trên băng ghế huấn luyện là nhà cầm quân Ramiro Lopez, người từng dẫn dắt futsal Tây Ban Nha.|Dựa vào lịch tranh tài, bạn rất có thể chuẩn bị xếp việc làm


    June 8, 2021 at 17:47 | Report abuse | Reply
  50. 청주출장

    I blog quite often and I genuinely thank you for your content. The article has really peaked my interest. I will book mark your website and keep checking for new details about once a week. I opted in for your Feed as well.


    June 8, 2021 at 20:25 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49

Leave a Reply to Samain


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.