home
RSS
October 5th, 2010
08:35 AM ET

Can antidepressants raise liver enzymes?

Every weekday, a CNNHealth expert doctor answers a viewer question. On Tuesdays, it's Dr. Charles Raison, an associate professor of psychiatry and behavioral sciences at Emory University, and an expert in the mind-body connection for health.

Question asked by Ann, of Bloomfield, New York

How do I help my daughter who has a diagnosis of bipolar and each time the doctors put her on an antidepressant, her liver counts go up and she goes into mania? This happens when the liver levels rise. It takes at least two weeks to cycle through.

Expert answer

Dear Ann,

The short answer to your question on how to help your daughter is to get her under the care of a clinician who will stop prescribing her antidepressants. We've known for years that antidepressants can worsen the course of bipolar disorder, at least in some patients. While some bipolar people take antidepressants without difficulty - and in fact need them - others have symptoms much like your daughter's every time they are placed on them.

Many psychiatric medications can increase "liver counts," by which you mean blood measures of liver enzymes. Usually this is not something to worry about. I've known some world-famous gastroenterologists who counsel psychiatrists not to worry about these short term rises in liver counts - even when the counts double. Every once in a while a medication will really damage the liver and counts will really shoot up. That is a different and very serious issue.

Although antidepressants can make bipolar patients manic and they can raise liver counts, these two effects are probably not connected. We are not sure how antidepressants induce mania. Recent studies suggest that people with certain genes are more likely than others to have this problem, and it is not just medications that can do this. Sleep deprivation is especially famous for its ability to make people manic.

I do not know your daughter's treatment history from this short question. Let me assume she has  been treated only with antidepressants. If so, the good news is that multiple other medications are likely to be of far more help to her both in terms of her depressions and manias. The classic medication in this regard is lithium. Newer medications that have been shown to stabilize mood in bipolar disorder include valproic acid (Depakote), carbamazepine and oxcarbazepine, lamotrigine (Lamictal) and several of a class of medications known as atypical antipsychotics.

I have seen countless people treated with the wrong medications who made remarkable recoveries when started on medications better suited to their diagnosis. Given your question, it is likely your daughter may be one of them.


soundoff (508 Responses)
  1. Digital Marketing Business

    This blog was... how do I say it? Relevant!! Finally I have found something which helped me. Thank you!

    http://neopolitanclothing.com/__media__/js/netsoltrademark.php?d=affordableranking.com

    May 9, 2021 at 21:24 | Report abuse | Reply
  2. Content Marketing Associations

    https://bigmarty.com/__media__/js/netsoltrademark.php?d=affordableranking.com

    May 10, 2021 at 16:49 | Report abuse | Reply
  3. Internet Marketing Mentors

    This is a topic which is close to my heart... Thank you! Exactly where are your contact details though?

    http://www.apollotheater.info/__media__/js/netsoltrademark.php?d=affordableranking.com

    May 10, 2021 at 20:18 | Report abuse | Reply
  4. Internet Marketing Agency Near Me

    This site was... how do I say it? Relevant!! Finally I have found something which helped me. Many thanks!

    https://www.ubisoftentertainment.com/__media__/js/netsoltrademark.php?d=affordableranking.com

    May 10, 2021 at 21:15 | Report abuse | Reply
  5. Internet Marketing Experts

    http://empiretrailer.com/__media__/js/netsoltrademark.php?d=www.affordableranking.com

    May 11, 2021 at 00:51 | Report abuse | Reply
  6. Social Media Marketing Firms

    http://www.quikstop.biz/__media__/js/netsoltrademark.php?d=www.affordableranking.com

    May 11, 2021 at 04:57 | Report abuse | Reply
  7. Google Marketing Jobs

    Greetings! Very useful advice in this particular post! It's the little changes that make the most important changes. Thanks a lot for sharing!

    http://1800therock.biz/__media__/js/netsoltrademark.php?d=affordableranking.com

    May 11, 2021 at 09:51 | Report abuse | Reply
  8. Digital Marketing Companies Near Me

    Spot on with this write-up, I honestly feel this web site needs a lot more attention. I’ll probably be back again to read through more, thanks for the info!

    http://stocking-amateur.com/cgi-bin/at/out.cgi?id=35&trade=http://affordableranking.com

    May 11, 2021 at 10:27 | Report abuse | Reply
  9. SEO

    İnternet sitelerinin arama motoru sonuç sayfasında daha üst sıralarda görünür olarak organik trafiğe erişmesini sağlayan backlink hizmeti, günümüzde blog sitelerinden e-ticaret sitelerine kadar internette görünürlük kazanmak isteyen her kullanıcı için hayati öneme sahip bir çalışmadır.

    https://www.guzelseo.com/seo/

    May 11, 2021 at 12:58 | Report abuse | Reply
  10. Social Media Marketing Agency California

    http://www.spiderhut.com/__media__/js/netsoltrademark.php?d=affordableranking.com

    May 11, 2021 at 13:36 | Report abuse | Reply
  11. Local Marketing Agency Costa Mesa

    http://daocapital.com/__media__/js/netsoltrademark.php?d=bestservicenearme.com

    May 11, 2021 at 14:28 | Report abuse | Reply
  12. Content Marketing Consultants

    http://www.onlinetransformationnation.biz/__media__/js/netsoltrademark.php?d=searchinteraction.com

    May 11, 2021 at 18:01 | Report abuse | Reply
  13. RV Bedroom Orange County

    Good site you've got here.. It’s difficult to find good quality writing like yours nowadays. I truly appreciate individuals like you! Take care!!

    https://handi-gun.com/__media__/js/netsoltrademark.php?d=facebook.com/ocrvcenter

    May 11, 2021 at 19:14 | Report abuse | Reply
  14. Mercedes Benz Sprinter Repair Shops Near Me

    http://www.nap.halfmoon.jp/ps_nappy1/ps_search.cgi?act=jump&access=1&url=https://fleettruckrepairshop.com/sprinter-van-technician-shop-near-me

    May 11, 2021 at 19:48 | Report abuse | Reply
  15. dashboard restoration near me

    https://bibliopam.ec-lyon.fr/fork?https://ocrv.world/rv-repair-shop-arcadia-california

    May 11, 2021 at 20:46 | Report abuse | Reply
  16. oc windshield

    http://www.artshub.com.au/job-apply-external/?ListingId=227894&ApplyUrl=https://ocrv.vip/rv-repair-shop-santa-clarita-california

    May 11, 2021 at 21:21 | Report abuse | Reply
  17. vinyl repair near me

    Greetings! Very helpful advice in this particular post! It is the little changes that produce the most significant changes. Many thanks for sharing!

    https://www.vdyoutube.com/watch?v=M52GtxyYxfE

    May 11, 2021 at 21:36 | Report abuse | Reply
  18. windshield repair orange ca

    https://www.banan.cz/goto.php?url=https://ocrv.world/discovery-trailer-collision-repair-paint-shop-near-me-orange-county

    May 11, 2021 at 22:20 | Report abuse | Reply
  19. RV Repair Los Angeles

    Hi, I do believe this is a great site. I stumbledupon it 😉 I will come back yet again since I book marked it. Money and freedom is the best way to change, may you be rich and continue to guide others.

    http://www.limelightinteractive.net/__media__/js/netsoltrademark.php?d=yelp.com/biz/ocrv-center-anaheim-2

    May 11, 2021 at 23:27 | Report abuse | Reply
  20. RV Leak Riverside

    Very nice article. I absolutely love this website. Thanks!

    http://www.hollandhospital.org/click.aspx?url=http://facebook.com/ocrvcenter

    May 12, 2021 at 01:50 | Report abuse | Reply
  21. rv step repair parts

    Oh my goodness! Incredible article dude! Thanks, However I am experiencing issues with your RSS. I don’t know the reason why I can't join it. Is there anybody else getting similar RSS issues? Anybody who knows the solution can you kindly respond? Thanx!!

    http://yellowpages.sooeveningnews.com/__media__/js/netsoltrademark.php?d=ocrvcenter.mobi/medical-bus-collision-repair-paint-shop-near-me-orange-county

    May 12, 2021 at 02:48 | Report abuse | Reply
  22. RV Solar Panels Systems California

    Spot on with this write-up, I absolutely think this site needs far more attention. I’ll probably be returning to see more, thanks for the info!

    http://www.desene-animate-online.net/__media__/js/netsoltrademark.php?d=instagram.com/ocrvcenter

    May 12, 2021 at 04:07 | Report abuse | Reply
  23. RV Batteries Riverside

    After exploring a handful of the blog posts on your web page, I really appreciate your way of writing a blog. I bookmarked it to my bookmark website list and will be checking back in the near future. Please check out my website as well and let me know how you feel.

    https://www.esdlife.com/goto.asp?url=yelp.com/biz/ocrv-center-anaheim-2

    May 12, 2021 at 05:01 | Report abuse | Reply
  24. truck shop in orange

    I blog frequently and I seriously appreciate your content. The article has truly peaked my interest. I am going to bookmark your blog and keep checking for new details about once a week. I opted in for your RSS feed as well.

    http://wamu.style.coocan.jp/click/click3.cgi?cnt=counter&url=https://ocrv.art/rv-fiberglass-repair-near-me

    May 12, 2021 at 05:58 | Report abuse | Reply
  25. 2006 Sprinter Climate Control Repair

    http://v.wcj.dns4.cn/?c=scene&a=link&id=8833621&url=https://fleetvehiclerepairshop.com/sprinter-van-restoration-shop-near-me

    May 12, 2021 at 08:48 | Report abuse | Reply
  26. Mercedes Sprinter Start Error Fault Repair

    Oh my goodness! Impressive article dude! Thanks, However I am experiencing difficulties with your RSS. I don’t understand why I can't subscribe to it. Is there anybody having similar RSS issues? Anybody who knows the answer can you kindly respond? Thanx!!

    http://register.scotland.org/Subscribe/WidgetSignup?url=https://fleetvehiclerepairshop.com/gmc-cargo-van-repair-shop-near-me

    May 12, 2021 at 09:03 | Report abuse | Reply
  27. mcd shades troubleshooting

    http://bd.jinti.com/Return/go.asp?mail_id=20170911jd&url=https://youtube.com/watch?v=TNQ1tAOW16k

    May 12, 2021 at 09:27 | Report abuse | Reply
  28. South Haven Michigan Mercedes Sprinter Repair Near Me

    https://media.stellantisnorthamerica.com/securedredirect.do?redirect=https://fleetservicerepairshop.com/business-van-repair-shop-near-me

    May 12, 2021 at 12:10 | Report abuse | Reply
  29. monrovia collision center

    I love it when folks get together and share thoughts. Great blog, continue the good work!

    http://www.odmp.org/link?url=https://youtube.com/watch?v=eJXp0Vd6T38

    May 12, 2021 at 15:51 | Report abuse | Reply
  30. motorhome body shop

    https://nanostandards.ansi.org/banner_click.php?id=2&url=https://ocrv.today/boom-truck-collision-repair-shop-near-me

    May 12, 2021 at 16:01 | Report abuse | Reply
  31. rv repair near me now

    https://shop.merchtable.com/users/authorize?return_url=https://ocrvcenter.org/motorhome-slide-out-repair-near-me

    May 12, 2021 at 22:15 | Report abuse | Reply
  32. gallery xnxx

    https://moshtix.com.au/v2/ForceDesktopView?callingUrl=https://youtube.com/watch?v=cFdp4R3ssow

    May 12, 2021 at 22:58 | Report abuse | Reply
  33. paint job shops near me

    Hello there! This article couldn’t be written any better! Reading through this article reminds me of my previous roommate! He always kept talking about this. I'll send this article to him. Pretty sure he will have a very good read. Thanks for sharing!

    http://bd.jinti.com/Return/go.asp?mail_id=20170911jd&url=https://ocrv.biz/rv-blinds-repair-near-me

    May 12, 2021 at 23:07 | Report abuse | Reply
  34. c and o body shop

    https://monitor.clickcease.com/tracker/tracker?id=Tcmwi3RgKQiVSy&kw=yahoobacklinks&nw=g&url=https://ocrvmotorcoaches.com/rv-plumbing-repair-near-me

    May 13, 2021 at 02:15 | Report abuse | Reply
  35. Service B Mercedes Sprinter

    Howdy! This blog post couldn’t be written any better! Going through this post reminds me of my previous roommate! He constantly kept preaching about this. I most certainly will forward this post to him. Pretty sure he'll have a good read. I appreciate you for sharing!

    http://find.cambridgesoft.com/help/cs.html?url=https://fleetservicesorangecounty.com/van-conversion-shop-near-me

    May 13, 2021 at 11:57 | Report abuse | Reply
  36. RV Interior Remodeling Orange County

    http://reshaping.ru/redirect.php?url=http://yelp.com/biz/ocrv-center-anaheim-4

    May 13, 2021 at 12:24 | Report abuse | Reply
  37. dash board repair

    After looking at a number of the blog posts on your site, I really appreciate your technique of blogging. I book marked it to my bookmark website list and will be checking back in the near future. Please check out my website as well and tell me what you think.

    https://scripts.affiliatefuture.com/AFClick.asp?affiliateID=29219&merchantID=2543&programmeID=6678&mediaID=0&tracking=&url=https://ocrvart.com/class-8-truck-collision-repair-shop-near-me

    May 13, 2021 at 15:10 | Report abuse | Reply
  38. RV Remodel California

    http://www.alfredosautosales.com/?wptouch_switch=desktop&redirect=http://

    May 13, 2021 at 17:26 | Report abuse | Reply
  39. collision repair riverside ca

    I really like reading an article that will make people think. Also, many thanks for permitting me to comment!

    http://cssdrive.com/?URL=ocrvcenter.org/rv-repair-shop-beverly-hills-california

    May 13, 2021 at 21:36 | Report abuse | Reply
  40. RV Center Los Angeles

    This is a topic that is close to my heart... Best wishes! Where are your contact details though?

    http://allmammoth.com/tosite.php?url=http3A2F2Fg.page/ocrvcenter&pageid=11944

    May 14, 2021 at 01:01 | Report abuse | Reply
  41. furniture repair orange county ca

    http://www.themza.com/redirect.php?r=youtube.com/watch?v=JLeDOSO97T0

    May 14, 2021 at 02:40 | Report abuse | Reply
  42. RV Shades Riverside

    Oh my goodness! Incredible article dude! Thanks, However I am having difficulties with your RSS. I don’t know the reason why I cannot subscribe to it. Is there anyone else getting similar RSS issues? Anybody who knows the answer can you kindly respond? Thanks!!

    http://www.metalindex.ru/netcat/modules/redir/?&site=http://yelp.com/biz/ocrv-center-yorba-linda-2

    May 14, 2021 at 05:28 | Report abuse | Reply
  43. RV Center California

    Hello! I simply would like to give you a big thumbs up for your excellent info you've got right here on this post. I'll be coming back to your site for more soon.

    https://www.tahoejoefamoussteakhouse.net/__media__/js/netsoltrademark.php?d=

    May 14, 2021 at 07:54 | Report abuse | Reply
  44. rv replacement parts near me

    An interesting discussion is worth comment. I believe that you should publish more about this subject, it might not be a taboo subject but typically people do not discuss these subjects. To the next! Best wishes!!

    http://www.openherd.com/adredirect.aspx?adType=SiteAd&ItemID=9539&ReturnURL=https://ocrv.art/motorhome-bedroom-repair-near-me

    May 14, 2021 at 10:10 | Report abuse | Reply
  45. rv trailer repair near me

    Very good article. I will be going through a few of these issues as well..

    https://www.t10.org/cgi-bin/s_t10r.cgi?First=1&PrevURL=https://ocrv.biz/nationwide-rv-collision-repair-shop-near-me

    May 14, 2021 at 10:13 | Report abuse | Reply
  46. RV Driver Seats Near Me

    This is a topic which is near to my heart... Cheers! Exactly where are your contact details though?

    http://www.tagtoll.net/__media__/js/netsoltrademark.php?d=youtube.com/channel/UChUH5GdtSzHx6V02C90mnfQ/videos

    May 14, 2021 at 10:14 | Report abuse | Reply
  47. RV Shades Riverside

    http://www.omniaindustries.net/__media__/js/netsoltrademark.php?d=facebook.com/ocrvcenter

    May 14, 2021 at 11:09 | Report abuse | Reply
  48. rex trailers horse

    https://login-tk.ewe.de/module.php/core/loginuserpass.php?AuthState=_f129e4d348645839698b4d7d776dd3affbd987fedc:https://ocrvcenter.net/semi-truck-collision-repair-paint-shop-near-me-orange-county

    May 14, 2021 at 11:18 | Report abuse | Reply
  49. Sclera Lenses

    https://ttf.sdsu.edu/?URL=arizonasvision.com

    May 14, 2021 at 16:44 | Report abuse | Reply
  50. Waves Maserati

    http://eforce.todayir.com/en/fileview.php?file=https://club-maserati.com/

    May 14, 2021 at 16:57 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.