home
RSS
October 5th, 2010
08:35 AM ET

Can antidepressants raise liver enzymes?

Every weekday, a CNNHealth expert doctor answers a viewer question. On Tuesdays, it's Dr. Charles Raison, an associate professor of psychiatry and behavioral sciences at Emory University, and an expert in the mind-body connection for health.

Question asked by Ann, of Bloomfield, New York

How do I help my daughter who has a diagnosis of bipolar and each time the doctors put her on an antidepressant, her liver counts go up and she goes into mania? This happens when the liver levels rise. It takes at least two weeks to cycle through.

Expert answer

Dear Ann,

The short answer to your question on how to help your daughter is to get her under the care of a clinician who will stop prescribing her antidepressants. We've known for years that antidepressants can worsen the course of bipolar disorder, at least in some patients. While some bipolar people take antidepressants without difficulty - and in fact need them - others have symptoms much like your daughter's every time they are placed on them.

Many psychiatric medications can increase "liver counts," by which you mean blood measures of liver enzymes. Usually this is not something to worry about. I've known some world-famous gastroenterologists who counsel psychiatrists not to worry about these short term rises in liver counts - even when the counts double. Every once in a while a medication will really damage the liver and counts will really shoot up. That is a different and very serious issue.

Although antidepressants can make bipolar patients manic and they can raise liver counts, these two effects are probably not connected. We are not sure how antidepressants induce mania. Recent studies suggest that people with certain genes are more likely than others to have this problem, and it is not just medications that can do this. Sleep deprivation is especially famous for its ability to make people manic.

I do not know your daughter's treatment history from this short question. Let me assume she has  been treated only with antidepressants. If so, the good news is that multiple other medications are likely to be of far more help to her both in terms of her depressions and manias. The classic medication in this regard is lithium. Newer medications that have been shown to stabilize mood in bipolar disorder include valproic acid (Depakote), carbamazepine and oxcarbazepine, lamotrigine (Lamictal) and several of a class of medications known as atypical antipsychotics.

I have seen countless people treated with the wrong medications who made remarkable recoveries when started on medications better suited to their diagnosis. Given your question, it is likely your daughter may be one of them.


soundoff (632 Responses)
  1. Camper Repairs Near Me

    You've made some decent points there. I looked on the net for more info about the issue and found most people will go along with your views on this site.

    https://foro.infojardin.com/proxy.php?link=http://www.ocrv.us/rv-repair-shop-hawthorne-california/

    June 19, 2021 at 17:02 | Report abuse | Reply
  2. RV Repair Seal Beach

    https://www.wrasb.gov.tw/opennews/opennews01_detail.aspx?nno=2014062701&return=https://www.ocrvcenter.com/rv-repair-shop-anaheim-california

    June 19, 2021 at 18:58 | Report abuse | Reply
  3. RV Repair San Clemente California

    http://pichak.net/verification/index.php?n=39&url=www.theocrv.com/elliott-truck-collision-repair-paint-shop-near-me-orange-county/

    June 19, 2021 at 19:33 | Report abuse | Reply
  4. Camper Repair Places Near Me

    Pretty! This was an incredibly wonderful article. Thank you for providing these details.

    http://www.vi.paltalk.com/client/webapp/client/External.wmt?url=ocrvcenter.com/rv-repair-shop-claremont-california

    June 19, 2021 at 21:22 | Report abuse | Reply
  5. RV Repair Near Me

    Very nice write-up. I definitely appreciate this site. Stick with it!

    https://www.faseb.org/pdfviewer?loadthis=http://www.ocrvcenter.com/rv-repair-near-me/

    June 19, 2021 at 22:41 | Report abuse | Reply
  6. RV Repair Orange County

    https://www.kronenberg.org/download.php?download=http://www.ocrvcenter.com/rv-repair-shop-warner-center-california/&filename=rpn-calculator_0.9.0.wdgt.zip&project=RPN-Calculator

    June 19, 2021 at 23:32 | Report abuse | Reply
  7. Video Marketing Business

    A fascinating discussion is worth comment. I think that you ought to write more about this subject matter, it might not be a taboo matter but generally people don't talk about such subjects. To the next! Many thanks!!

    http://e-que.com/__media__/js/netsoltrademark.php?d=www.https://affordableranking.com/

    June 20, 2021 at 03:43 | Report abuse | Reply
  8. Social Media Marketing Agency

    Iím impressed, I must say. Rarely do I come across a blog thatís equally educative and engaging, and without a doubt, you've hit the nail on the head. The problem is something not enough men and women are speaking intelligently about. I am very happy I stumbled across this during my hunt for something concerning this.

    http://www.trasportopersone.it/redirect.aspx?url=http://www.affordableranking.com/

    June 20, 2021 at 03:57 | Report abuse | Reply
  9. pharmaceptica.com

    sildenafil tablets online https://www.pharmaceptica.com/

    June 20, 2021 at 08:59 | Report abuse | Reply
  10. Shu Suydam

    https://anonym.to/?https://ppcpostfalls.com/

    June 20, 2021 at 15:03 | Report abuse | Reply
  11. Gabriele Cipro

    https://google.com.kw/url?q=https://ocrv.rocks

    June 20, 2021 at 19:44 | Report abuse | Reply
  12. Treasa Mcmillon

    https://www.bitly.com/a/warning?hash=3nUs1YL&url=http://www.cleanuponlinereputation.com

    June 20, 2021 at 20:05 | Report abuse | Reply
  13. RV Repair Shop

    There's definately a lot to find out about this subject. I love all the points you have made.

    http://vermontcoupon.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com

    June 21, 2021 at 01:26 | Report abuse | Reply
  14. RV Repair Orange County

    Hi there, I do believe your web site could possibly be having internet browser compatibility problems. When I take a look at your web site in Safari, it looks fine however, if opening in IE, it has some overlapping issues. I merely wanted to provide you with a quick heads up! Other than that, wonderful website!

    http://capitolahistory.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com

    June 21, 2021 at 06:10 | Report abuse | Reply
  15. movie theater near me

    http://db.cbservices.org/cbs.nsf/forward?openform&http://bulknearme.com/

    June 21, 2021 at 06:55 | Report abuse | Reply
  16. dog shelters near me

    http://optimalquest.com/__media__/js/netsoltrademark.php?d=masternearme.com

    June 21, 2021 at 09:24 | Report abuse | Reply
  17. RV Repair Shops Near Me Now

    Spot on with this write-up, I actually believe this web site needs far more attention. Iíll probably be back again to read more, thanks for the advice!

    http://suek.com/bitrix/rk.php?goto=https://ocrvcenter.com/

    June 21, 2021 at 11:07 | Report abuse | Reply
  18. us post office near me

    http://www.kyuuyo-pit.com/feed2js/feed2js.php?src=https://bestlocalnearme.com

    June 21, 2021 at 11:20 | Report abuse | Reply
  19. grocery near me

    Your style is so unique in comparison to other folks I've read stuff from. Thanks for posting when you've got the opportunity, Guess I will just book mark this page.

    http://art-gymnastics.ru/redirect?url=https://earme.a2hosted.com

    June 21, 2021 at 17:37 | Report abuse | Reply
  20. RV Awning Repair Near Me

    https://www.attaka.or.jp/cgi-bin/click3/click3.cgi?cnt=05&url=https://ocrvcenter.mobi/

    June 21, 2021 at 21:45 | Report abuse | Reply
  21. RV Repair Near Me Now

    Way cool! Some extremely valid points! I appreciate you writing this write-up plus the rest of the website is extremely good.

    http://oxfordendowment.com/__media__/js/netsoltrademark.php?d=ocrvmotorcoaches.com

    June 21, 2021 at 21:47 | Report abuse | Reply
  22. marketing coach near me

    http://www.schoolscheduleonline.net/__media__/js/netsoltrademark.php?d=www.mastermindofmen.com

    June 22, 2021 at 00:51 | Report abuse | Reply
  23. Rv Body

    Having read this I believed it was extremely enlightening. I appreciate you spending some time and effort to put this information together. I once again find myself spending a lot of time both reading and commenting. But so what, it was still worth it!

    https://www.lnfcu.com/helpers/choice.asp?h=http://sprinterrepairnearme.com/

    June 22, 2021 at 00:52 | Report abuse | Reply
  24. RV Repairs Nearby

    This website was... how do you say it? Relevant!! Finally I've found something which helped me. Thanks a lot!

    http://www.accidentlines.biz/__media__/js/netsoltrademark.php?d=www.ocrv.tv

    June 22, 2021 at 02:58 | Report abuse | Reply
  25. Sprinter Repair Shop Near Me

    http://purpleunicorn.com/__media__/js/netsoltrademark.php?d=fleetservicesocrv.com

    June 22, 2021 at 03:00 | Report abuse | Reply
  26. lifestyle group

    http://jedonne.com/__media__/js/netsoltrademark.php?d=menmastermind.com

    June 22, 2021 at 09:17 | Report abuse | Reply
  27. Faustino Brayley

    Good article. I am going through many of these issues as well..

    https://community.rsa.com/t5/custom/page/page-id/ExternalRedirect?url=https://www.nearme.a2hosted.com/forklift-repair-service-shop-near-me

    June 22, 2021 at 12:04 | Report abuse | Reply
  28. Van Dent Repair Shop

    Your style is unique in comparison to other people I have read stuff from. Thank you for posting when you have the opportunity, Guess I will just book mark this site.

    http://pattysullivan.ca/__media__/js/netsoltrademark.php?d=campervanrepairshop.com

    June 22, 2021 at 12:58 | Report abuse | Reply
  29. pharmaceptica

    define hydrochloric https://www.pharmaceptica.com/

    June 22, 2021 at 13:04 | Report abuse | Reply
  30. RV Roof Repair Service Near Me

    http://factory-tools.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com

    June 22, 2021 at 16:01 | Report abuse | Reply
  31. joe rogan podcast spotify

    Hi, I do think this is a great site. I stumbledupon it 😉 I will return once again since i have bookmarked it. Money and freedom is the best way to change, may you be rich and continue to help others.

    http://farmbureauchallenge.com/__media__/js/netsoltrademark.php?d=www.backbonehunters.com

    June 22, 2021 at 17:10 | Report abuse | Reply
  32. dateline podcast

    http://deevy.com/__media__/js/netsoltrademark.php?d=www.backbonehunters.com/

    June 22, 2021 at 20:28 | Report abuse | Reply
  33. Local Marketing Experts

    http://santrasf.com/__media__/js/netsoltrademark.php?d=consciousgrowthmarketing.com

    June 22, 2021 at 21:08 | Report abuse | Reply
  34. Social Media Marketing Business

    http://goldfort.com/__media__/js/netsoltrademark.php?d=consciousgrowthmarketing.com/

    June 22, 2021 at 21:14 | Report abuse | Reply
  35. RV Brake Repair Near Me

    http://www.ireserve.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com

    June 22, 2021 at 23:10 | Report abuse | Reply
  36. tiny meat gang podcast

    http://www.worktrucksshow.net/__media__/js/netsoltrademark.php?d=backbonehunters.com

    June 23, 2021 at 00:16 | Report abuse | Reply
  37. Digital Marketing Companies Near Me

    This website certainly has all of the information I needed about this subject and didnít know who to ask.

    https://www.1-800-cookies.org/__media__/js/netsoltrademark.php?d=consciousgrowthmarketing.com/

    June 23, 2021 at 05:42 | Report abuse | Reply
  38. Internet Marketing Specialists

    http://www.overlex.com/vaia.asp?url=http://www.consciousgrowthmarketing.com

    June 23, 2021 at 06:41 | Report abuse | Reply
  39. Digital Marketing Near Me

    A fascinating discussion is definitely worth comment. There's no doubt that that you ought to publish more on this subject matter, it might not be a taboo matter but generally people don't talk about such topics. To the next! Cheers!!

    http://www.antos.com/__media__/js/netsoltrademark.php?d=consciousgrowthmarketing.com/

    June 23, 2021 at 06:50 | Report abuse | Reply
  40. pharmaceptica.com

    tadalafil side effects https://www.pharmaceptica.com/

    June 23, 2021 at 08:43 | Report abuse | Reply
  41. RV Repair Shops Near My Location

    Very good post! We will be linking to this great article on our site. Keep up the good writing.

    http://leefirstbaptistchurch.org/System/Login.asp?id=48747&Referer=https://ocrvluxurycoaches.com

    June 23, 2021 at 08:53 | Report abuse | Reply
  42. Content Marketing Services

    I could not refrain from commenting. Very well written!

    https://www.onlykansascity.com/__media__/js/netsoltrademark.php?d=consciousgrowthmarketing.com/

    June 23, 2021 at 10:02 | Report abuse | Reply
  43. Internet Marketing Firm Near Me

    http://nonstop-webs.net/__media__/js/netsoltrademark.php?d=internetmarketingoregon.com

    June 23, 2021 at 13:34 | Report abuse | Reply
  44. Internet Marketing Agencies Near Me

    http://rampe.com/__media__/js/netsoltrademark.php?d=postfallsvideographer.com

    June 23, 2021 at 15:47 | Report abuse | Reply
  45. Content Marketing Company

    http://ejtemaee.com/__media__/js/netsoltrademark.php?d=cdaseo.com/

    June 23, 2021 at 15:51 | Report abuse | Reply
  46. 15 minute covid test near me

    http://www.diwaxx.ru/hak/redir.php?redir=http://quotenearme.com/

    June 23, 2021 at 20:09 | Report abuse | Reply
  47. Video Marketing Agency

    http://eaglesmusic.tw/__media__/js/netsoltrademark.php?d=spokanevalleymarketing.com

    June 23, 2021 at 22:18 | Report abuse | Reply
  48. Internet Marketing Services Near Me

    http://romhacking.net.ru/go?https://callfeeder.com/

    June 24, 2021 at 01:37 | Report abuse | Reply
  49. RV Plumbing Repair Near Me

    Good post. I definitely love this website. Keep writing!

    http://needyinnewyork.com/__media__/js/netsoltrademark.php?d=ocrvart.com

    June 24, 2021 at 04:55 | Report abuse | Reply
  50. RV Repair And Service Near Me

    Hello! I simply want to offer you a huge thumbs up for your excellent information you have right here on this post. I'll be coming back to your web site for more soon.

    http://centre-group.net/__media__/js/netsoltrademark.php?d=ocrv.xyz

    June 24, 2021 at 05:12 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.