July 15th, 2010
06:50 PM ET

FDA panel says 'no' to new diet drug

An FDA advisory panel voted Thursday to recommend the rejection of Qnexa, a new diet drug that is a combination of two older medications. The vote was 10-6, with members apparently most concerned about the rate of cognitive and psychiatric side effects.

The hard-to-pronounce medication – call it “Qui-nex’-uh” – was developed by the company Vivus, and is a combination of two more familiar drugs. One, phentermine, is an amphetamine that made up the "phen" half of Fen-Phen, the diet drug that was pulled from the market in 1997 after some users died of heart valve problems. An FDA review of Qnexa blamed "Fen" – fenfluramine – for the deaths.

The other component of Qnexa is topiramate, an anti-seizure medication that has been investigated for a range of other uses, including the treatment of alcoholism. This spring, Johnson and Johnson, which markets topiramate under the brand-name Topamax, was accused of going overboard in its enthusiasm, paying an $81 million fine to settle charges that it illegally marketed the drug for unapproved therapies.

Qnexa is part of a wave of new diet drugs. At least two others – lorcaserin and Contrave  – are scheduled to go before the FDA panel by the end of this year.

soundoff (153 Responses)
  1. kurt

    well, whatever people might have to say about big government, I'm happy to see government taking action on this.

    July 15, 2010 at 19:04 | Report abuse | Reply
    • david

      What ever happened to us having the right to control our own bodies? If I want to risk the side effects of this drug, then it's my body, my choice!

      July 15, 2010 at 20:02 | Report abuse |
    • Sonia

      I agree, sometimes society is too dumb to take decisions like "read the side effects" or "stop having more children" so it's more cost effective for us to offer intelligent advice and pass out condoms and birth control...in the long run, we all win...yay for the government on thiis one...some people need help taking decsions!

      July 15, 2010 at 20:03 | Report abuse |
    • Jesus

      You lose weight, but you also lose your mind. We already have too many slim dimwits out there! Paris Hilton for one!

      July 15, 2010 at 20:26 | Report abuse |
    • deforge

      "I agree, sometimes society is too dumb to take decisions like "read the side effects" or "stop having more children" so it's more cost effective for us to offer intelligent advice and pass out condoms and birth control...in the long run, we all win...yay for the government on thiis one...some people need help taking decsions!"

      maybe the reason that there are so many dumb people is because the regulation made the existence so idiot proof that natural selection is no longer in effect?
      if so, then further regulation will only help further stupification of the society. ie, make things worse, not better.

      July 15, 2010 at 20:37 | Report abuse |
    • Todd

      If you get hurt by the drugs you could sue.

      This isn't tobacco you know.

      July 15, 2010 at 20:47 | Report abuse |
    • JC

      You can still take this "medication" this drug is just a combo pill of two existing meds, neither of which work well for weight loss. So instead of allowing a patent on a junk med, with significant side effects, the FDA has required the drug manufacturer to prove its benefits outweigh its risks....which they don't. Amazing concept I'm sure!

      July 15, 2010 at 22:18 | Report abuse |
    • Jen B

      Unfortunately, David, what happened is frivilous law suits. People will take this drug and if so much as even a pimple appears on them they'll head for the nearest lawyer; then more people will try to take hoping to ca
      sh in.

      July 15, 2010 at 23:34 | Report abuse |
    • tracy

      david, your right to control your own body is still yours. don't get overweight in the first place!! how about my right to not pay higher insurance premiums for prescription drugs or treatments resulting from obesity, oh excuse me, I mean personal choice.

      July 16, 2010 at 00:44 | Report abuse |
    • Sean

      David, it's your choice, but my money. If you take the drug, you will end up in hospital, and I will end up paying more on my insurance. You'll end up suing the company and further pushes up my premium. Thanks to you.... and those ignorant people like you.

      July 16, 2010 at 00:48 | Report abuse |
    • AlaskanDude

      Though normally I feel the FDA is too controlling particularly in the area of alternative medicine (natural remedies) I will defend the FDA a little bit. Without the FDA it could be conceivable that health care and medicine might actually cost more due to frivolous law suits. By banning dangerous drugs we avoid some lawsuits. All in all I wish they would give up on their stance of not allowing companies to market natural remedies as such. If you make a claim that any product can cure or relieve a problem they go in and shut it down and call it a drug.

      July 16, 2010 at 02:18 | Report abuse |
    • Nini

      Agree! Topamax should never have been marketed as a weight loss drug! Weight loss is just another one of it's many side effects.

      The logic of this was completely crazy in the first place. They wouldn't ever market it as a drug to help you get over your dr. pepper addiction, but the side effect that makes all pop taste completely awful certainly does that for you!

      July 16, 2010 at 03:10 | Report abuse |
    • Heather

      It is good to see FDA taking an interest in what we do to ourselves, however, that gives me no sense of relief. Did they test this drug for any amount of time at all? I think that what they allow and don't allow is directly related to the amount of money they get from the drug manufacturers. There are a myriad of European medicines that have been used for many years in Europe that the FDA will not allow to come here. There are no side effects, and a lot of the medicines that I have seen and used are made from natural ingredients (unlike US meds) so why can they not be sold here? It all comes down to extreme greed.

      July 16, 2010 at 05:40 | Report abuse |
    • Need2Read333

      I think the point is not so much the government trying to protect us from ourselves, as the government trying to force a bit of transparency and accountability from drug manufacturers. Without some sort of "watchdog", most drug companies would promise us magic without revealing the slightest of side effects.

      July 16, 2010 at 06:30 | Report abuse |
    • john c

      so does this mean we will take topamax off the market, since it is already approved and the side-effect profile with the combination drug Qnexa is no different than topamax alone. Sorry seizure patients, migraine sufferers who take the mediciation. FDA is too scared anymore to take actions that make logical sense.

      July 16, 2010 at 08:30 | Report abuse |
    • memo2

      Kurt, what this Government needs to do is Restructuring all the FDA.
      Too many mistakes from FDA are been made on approve many drugs already on the market.

      July 16, 2010 at 08:54 | Report abuse |
    • Ken

      sorry but wanted to get this at the top of the page:

      "An FDA review of Qnexa blamed "Fen" – fenfluramine – for the deaths." Pretty sure they should have said

      An FDA review of FEN-PHEN blamed "Fen" – fenfluramine – for the deaths.

      CNN, who's proofreading this stuff??

      July 16, 2010 at 09:04 | Report abuse |
    • Jessica

      deForge – here's another concept, how about we do not allow ANY medications on the market for things that we can cure through our own efforts – such as weight loss. If you want to talk about "dumbing the people down" – thats exactly what medicine in general does. Got diabetes? eh...dont bother exercising and eating right, take this pill and VOILA! You're all better...er, sort of. Got a beer belly from your college years? Dont exercise and lose weight, take this "magical" weight loss pill (never mind the silly side affects!)...got high blood pressure? Dont change your eating habits, just take these meds. got sleep apnea because you're huge and you might die in your sleep? Dont lose weight...just strap this machine to your head at night!....we are already a stupid society with a medical system getting horrendously too expensive...I dont think we need more lawsuits from the stupids because they didnt "understand" the side affect warnings. At this point, a little more dumbing down wont really matter much.

      July 16, 2010 at 09:33 | Report abuse |
    • Chasaty

      The reason government has to have some say over people's bodies is because people are too self absorbed to think about the other people who have to deal with the choices you make with your body. If you decide you wanna be morbidly obese, when you get rushed to the ER, doctors have to work unusually hard to deal with your fat a55. If you die 700lbs, the mortician and staff has to do rediculous tricks to get your big a55 into a casket and its 10x harder to embalm a severely overweight person than it is for normal people.

      If you decide to commit suicide by running into traffic, you got what you wanted but...you caused harm to other people too. If you choose to be a drug addict, another person has to resuscitate you when you overdose and taxpayers money gets wasted on you. If you choose to keep having babies with no way to take care of them...it comes out of MY paycheck. So thats why government needs to have "some" say in what we do with out bodies.

      July 16, 2010 at 09:41 | Report abuse |
    • Walter

      @ Tracy – "it's your choice, but my money," you say then provide some specious "down-the-road" argument about lawsuits and future hospitalization costs. Hmmm. Interesting. Does that work with, say, abortion? I mean, it's my money in the health care bill why should I pay for YOUR abortion? Dems said we wouldn't. Obama said we wouldn't. Joe Wilson called Obama a liar and the liberal world was outraged. Yet, look at that – Feds approve release of funds to Pennsylvania high-risk pool which provides... (DUM-DUM-DUM) abortions! Why, how surprising!

      Hey, Tracy, if I have to pay for your abortions, you gotta pay for my Qnexa hospitalization and lawsuit. 'Kay?

      July 16, 2010 at 09:43 | Report abuse |
    • Wendy

      Don't get fat in the first place – personal responsibility – Make good eating choices and exercise!

      July 16, 2010 at 09:50 | Report abuse |
    • PHinMiami

      DAVID – Yeah right, you'll be the 1st one to sign up for the 'class-action' lawsuit.

      July 16, 2010 at 10:33 | Report abuse |
    • A. Goodwin

      Agreed! I've watched my son go through terrible side effects from Topomax as he is an epileptic. One week on the drug and we took him off. This drug no way, no how should be made into a diet pill.

      July 16, 2010 at 10:46 | Report abuse |
    • Lee

      Yes beaurocratic big brother will cause delays and take "votes" meanwhile people suffer and die. The FDA has a dismal record and provides very little for what is put into it. Private test test firms could be much more effective. And we saw during the Bush admin that the FDA was politically controlled, where birth control is voted down simply because it goes against the religion in power.

      July 16, 2010 at 10:55 | Report abuse |
    • Tanya K

      I say, send all of us who have problems controlling our food consumption to distribute food for those who are starving. I am sure it would put things in perspective for many. All those millions spend developing drugs to 'treat' obesity, could have been spent eradicate hunger.

      July 16, 2010 at 11:36 | Report abuse |
    • Robert

      It's a myth that people go out and have 'too many children'. Oh some – the octomom comes to mind, but overall, we don't have enough children to maintain the population, you'd need 2.1 children per female, to have a steady population...we have less than that, by birthrate alone, we'd be in population decline.

      The only reason we, like most of Europe are not in population decline, is because of immigration. Like immigration or don't, its the only reason the U.S. isn't in the disastrous population decline.

      Why do I say disastrous? Smaller population = less workers = smaller economy. You can't hire more people, than you have. It may seem logical to want less people here because we already have so few jobs, but recessions often last a few years, raising up children takes a couple decades...so short term thinking, doesn't apply when discussing population trends. In the long term, we have multiple trillions in promised obligations that can only be paid by taxing workers – and lots of them.

      Population decline doesn't fit into any strategy we have for paying all those obligations, and lets not be indirect, these aren't merely 'obligations' but most consider them to be really important – retirement wages for the elderly, prescription drug programs, etc.

      July 16, 2010 at 11:52 | Report abuse |
    • Terry Malloy

      I am happy to see the FDA keeping big drug companies feet to the fire with these fines but I have a better idea. These fines are not meant as revenue streams for the FDA, they are to deter companies from the kind of thing that J&J did, so why not fine them $40 million and create a pool with the balance. Give $1 million each to 41 start-ups. A million dollars would go a long way for these atart-ups not to mention the people it could put to work and the potential drug or device it could help create.

      July 16, 2010 at 13:09 | Report abuse |
  2. SurRy

    More "big government" interference with the "free market"!

    July 15, 2010 at 19:10 | Report abuse | Reply
    • me

      there are some times went the government needs to protect us from corporations. Just look at the economic mess that the corps made.

      July 15, 2010 at 19:18 | Report abuse |
    • SurRy

      I didn't realize I needed a sarcasm tag!

      July 15, 2010 at 19:36 | Report abuse |
    • Sonia

      Geez so go ahead and buy it for all your family....seriously? You wish bad drugs to be sold as good drugs on the market? You must not have children!

      July 15, 2010 at 20:05 | Report abuse |
    • SurRy

      Again, I didn't realize I needed a sarcasm tag!

      July 15, 2010 at 23:06 | Report abuse |
    • Laurien

      You do need a sarcasm tag until you are halfway decent at it and understand what sarcasm is. A tag is necessary here. And I am not being sarcastic.

      July 16, 2010 at 01:00 | Report abuse |
    • Lee

      It is interference and that is not sarcasm. Why can't people just be warned and let them decide for themselves. There is no reason this should be a government organization except to waste taxpayer money and to have stupid thing occur, like how birth control pills were denied during the Bush admin for no scientific reason at all, just the religious people were against the idea.

      July 16, 2010 at 10:58 | Report abuse |
    • Robert

      Per the subject, would people make bad decisions if allowed to do so? Yes.

      Is that OK? Yes.

      I'd rather live in a society where someone can weigh the risks of being obese vs. the risks of this diet drug, where simply the facts where presented to them, and it became their choice.

      I think the reason this has touched a nerve – is people simply want a diet drug that works. PhenFen worked. Diet drugs that are safe – also don't work, which means that a very unsafe condition is left in place – obesity.

      The solution to obesity – eat wild caught fish, legumes, nuts, olive oil, fruits, vegetables, whole grain breads – that's great, except when my coworkers invite me to lunch, those won't be on the menu.

      If I want to feed my whole family these foods, my food bill would triple. The generic white bread/wheat bread is 89 cents a loaf at Kroger, 'artisan' grain breads are $3 a loaf. Lean hamburger is twice the regular hamburger. Wild caught fish is triple farmed fish. Switching to more fruits means frequently going to the grocery, adding to transportation costs, on top of the fact that fruit is expensive too.

      It's hard to diet, because also – your mood goes through a horrible depression, and you have a job to work as well.

      Frankly some people don't understand, but a lot of people do, I mean most americans are overweight or obese.

      I wish the government, instead of removing choices, thought it was their job to increase choices. Don't let someone run a public restaurant without at least having a healthy menu – to coincide with their terrible menu.

      I'm about to go to lunch, I'd grab something healthy – if that were a choice, it won't be.

      July 16, 2010 at 12:17 | Report abuse |
  3. steve

    so what doesnt make sense is why they would continue avandia and decline this medication?

    July 15, 2010 at 19:14 | Report abuse | Reply
    • Gpenn

      Steve, please give us a run down on the mechanisms of each drug and the problems that have occured in the drug trials of each?

      July 15, 2010 at 19:35 | Report abuse |
    • JC

      Avandia had already been approved. It is more difficult to remove a drug from the market than it is to approve it to begin with. This is a good medical decision. This drug is nothing more than a "market-share" attempt to combine two ineffective drugs for weight loss, and make some $$$$ off poor physician and patient judgment.

      July 15, 2010 at 22:20 | Report abuse |
  4. me

    I guess they did not pay the FDA enough to get it approved.

    July 15, 2010 at 19:17 | Report abuse | Reply
    • Sonia

      Yup! Right on the nose!

      July 15, 2010 at 20:05 | Report abuse |
    • Steve

      The FDA does not get paid by drug companies. Your comment is simply an uninformed one.

      July 15, 2010 at 21:51 | Report abuse |
    • It is I

      Can I get an Amen

      July 15, 2010 at 22:26 | Report abuse |
    • Jessica

      Of course the FDA does not DIRECTLY get paid by drug companies, but you're naive to believe that lobbyist dollars do not sway the FDA's judgement, or to believe that the FDA isnt stacked with "drug manufacturer sympathizers". Kind of like our supreme court got stacked with corporatists under Dubya (corporations were ruled to be "people", except when you could hold them liable for the death penalty, then they are just "corporations")

      July 16, 2010 at 09:39 | Report abuse |
  5. Kate

    Seems like the "keep people fat" community- diet foods, diet books, diet shakes and work out programs have a large enough lobby to keep people from accessing a pill that might make it easier for them to lose weight and therefore become healthier, and avoid obesity related diseases which cost consumers of medical insurance millions of dollars a year...hmmm that sounds exactly LIKE big government to me.

    July 15, 2010 at 19:25 | Report abuse | Reply
    • guinea pig

      volunteer for a drug study. if it does not kill you, it might work.

      July 15, 2010 at 19:30 | Report abuse |
    • SurRy

      Why does there have to be a pill to lose weight? Stop putting the food in your mouth!

      July 15, 2010 at 19:38 | Report abuse |
    • lj

      Topomax is NOT the answer. As a migraine patient who has taken this medication for years, I can tell you that side effects are debilitating. I only take the drug because without it, I suffer from daily migraines.

      However, the dosages needed for significant weight loss in some people lead to severe confusion, dizziness, insomnia and major anxiety and irritability.

      Also, what they don't tell you is that Topomax messes with your metabolism so badly that when you go off of it, you will gain weight back to where you were and then some. Your ability to metabolize fat has been changed thanks to the medication.

      Trust me. This pill is not the answer.

      July 15, 2010 at 19:56 | Report abuse |
    • lj


      An ignorant answer if ever there was one. It's not always about the amount of food. There are metabolic disorders and other illnesses that lead to obesity. A person can gain weight on a 1800 calorie diet.

      Try to be informed before commenting.

      July 15, 2010 at 19:58 | Report abuse |
    • Derk

      yes but with a 25% obesity rate( yes that is obesity, we are not counting over weight ), I doubt that 25% of all Americans have metabolic illness and other issues

      July 15, 2010 at 20:36 | Report abuse |
    • Kv

      @lj – I already take Topamax for migraines and I've never suffered any side effects from the medication. It only made my nose tingle in the beginning after I took my pill. Due to the medication I do not notice I'm hungry if at all so I just have to remind myself to eat if I notice it's growing late.

      The medication is safe when taken properly and under supervision. If you suffer debilitating side effects from it, there are six other medications that do the same thing as Topamax which my doctor would have put me on if Topamax didn't work perfectly right off the bat.

      July 15, 2010 at 21:27 | Report abuse |
    • lj


      Perhaps you're not on the same dosage I am. I have tingling in my hands and feet along with confusion and memory loss. Side effects I've not had on other medications. Sadly, the other medications did not work in preventing migraines.

      My doctor is well aware of the side effects and yes, I'm taking the medication under supervision. These side effects are worth it to avoid pain but certainly not worth it for weight loss.

      July 15, 2010 at 21:47 | Report abuse |
    • lj


      Honey, read the comment. I didn't say all obesity was related to metabolic disorders. I said "It's not always"

      Not always. As in "not all" as in not everyone who is obese.

      Fat shaming? Not cool

      July 15, 2010 at 22:01 | Report abuse |
    • JC

      This drug has not been proven to make people healthier, in fact the reason this was not approved is that it makes people more likely to die or suffer serious health consequences. Risk>>>>Benefit here. These drugs are not new and have never been shown to reduce morbidity or mortality related to obesity or lack thereof.

      July 15, 2010 at 22:23 | Report abuse |
    • jrk

      try midrin for your migraines i liked it alot better than topimax and i didnt get the icky side effects!

      July 15, 2010 at 22:29 | Report abuse |
    • GMan83

      The "keep people fat" community you've labeled is ignorantly labeled. Trainers, dietitians, etc. are all a by-product of the Fast Food generation. Your blame should be placed elsewhere; to fast food restaurants, chain restaurants, and the obese themselves in most cases. About 2% of obese people are incapable of shedding the weight through exercise and a healthy diet. People just aren't strong willed enough and get caught into cycles of self-loathing. They want to lose the weight but in their mind, they don't NEED to lose it.

      July 15, 2010 at 22:38 | Report abuse |
    • SurRy

      @lj – I am informed. True metabolic reasons for weight gain are few and far between. It's a common excuse, but not a common reason.

      July 15, 2010 at 23:08 | Report abuse |
    • Laurien

      SurRy; you are not funny and you aren't as informed as you would like to believe. There are many factors to obesity; hormone imbalances, insulin resistance, poverty, education, brain chemistry, stress. Food itself is engineered to make you want more, more, more, affecting frontal lobe function. The problem cannot be isolated to one blanket statement. It's very easy to say "stop putting food in your mouth", but if that was a realistic solution, there would be no obesity.

      July 16, 2010 at 01:06 | Report abuse |
    • SurRy

      @ Laurien – Not trying to be funny at all. Obesity is a horrible problem in this country. I believe I was only addressing the "metabolism" excuse. I did not mention any of the other biochemical or socio-economical factors you brought up. And yes, I know what they are. A "pill" is not the cure for everything. I would prefer my tax dollars be used to supply our citizens with health nutritious food rather than fund war (but that's a discussion for another day.) Education, self-control and proper nutrition would be a good start to solving obesity problem in this country.

      July 16, 2010 at 08:06 | Report abuse |
    • Jessica

      Laurien – "It's very easy to say "stop putting food in your mouth", but if that was a realistic solution, there would be no obesity." That is the point to all of this though...IF IT WERE THAT EASY. people want a frickin easy button, and there is not one, period. You have to actually WANT to lose the weight, and you have to actually WANT to put in the effort – if you dont of course nothing is going to change, of course its going to feel "hard". But, be honest with yourself, these are all excuses – every single reason listed is just an excuse. The true "medical reasons" why someone cant lose weight – despite trying really really really hard, are few and far between, because in general, people dont actually try very hard at all. They think they do, they spend 10 minutes walking and they think "well geez, why didnt I just lose weight...why bother, this is pointless". As a former smoker – I know that all it takes to quit smoking is TRULY WANTING to. period, there's no other magic to it. After lots of "failed" attempts at quitting...the only difference between when I was successful and I wasnt – was my desire. PERIOD. The same was true with weight loss – I love "bad" food...I admit it, and on top of that im a self-professed "lazy" person. I hate exercise, but at the end of the day...if I really want to lose weight, thats when I do. You have to want it – not just want to he end result, otherwise...yep, it is impossible. But thats not because of all the excuses you mentioned. simply because of your inability to truly want it. most people just do not want it, they really dont.

      July 16, 2010 at 09:52 | Report abuse |
    • Chasaty

      While thin people feel like everyone is retarded because they are not also thin, normal people know that eating roast beef and potatoes 30 years ago isnt like roast beef and potatoes today. The food now is so jammed packed with hormones and preservatives and chemicals that keep you hungry.

      While a fitness guru may argue that exercising and eating a healthy diet will guarantee you health, they too are wrong. "Fit" people get cancer, std's, blood borne illnesses, etc.

      If it was as simple as not eating the food, im sure people would do that. There are many reasons for people who overeat. Some are just pigs, some have emotional issues, some people eat until they are full(which may be more than a carrot and some cottage cheese), some people have a medical issue, some have a psychological issue, and some biological.
      Not all pigs are fat either. My brother weighs 150lbs and he is 6'1, his diet consists of french fries, onions rings, cheeseburgers, and hamburger helper. Now according to the Overweight-Nazis, what you eat determines your size with no biological influence. How do you explain skinny people who eat like pigs?

      July 16, 2010 at 10:20 | Report abuse |
    • A. Goodwin

      Kv – I think you are in the minority. My son took Topomax for epilepsy and we took him off of it in a week due to side effects. Everyone is different – yes, but to say because you had no side effects so it must be safe and should be made into a diet pill is fairly ignorant. My son is not seizure free and the ultimate consequence if he had a bad seizure is DEATH....so we've had to try many different drugs. Topomax was by far, one of the WORST.

      July 16, 2010 at 10:44 | Report abuse |
    • Paul

      Are you suggesting Kate that diet and exercise "People" are lobbying that magical diet pills will make weight loss too easy?

      If it's too good to be true, it's probably a sham.

      While a pill might help with weight loss, you're still going to need the diet and exercise, no one ever got thin from obese just sitting around popping pills. It takes hard work.

      July 16, 2010 at 11:31 | Report abuse |
  6. John Philadell

    So they won't approve this drug due to possible cognitive and psychiatric side effects.but will leave a drug on the market that has actually contributed to the death of people (Avandia)? My understanding was that the possible side effects weren't that bad whereas death is pretty bad.

    July 15, 2010 at 19:25 | Report abuse | Reply
    • lj

      Death benefits pay less than injury. Sad but true

      July 15, 2010 at 22:04 | Report abuse |

    there are lots of drugs that kill people on the market, but when one makes people lose weight we draw the line.

    July 15, 2010 at 19:30 | Report abuse | Reply
    • Jessica

      But this drug doesnt actually do that...cause people to lose weight. So, you just want them to approve drugs that dont work and have bad side affects? sounds logical...

      July 16, 2010 at 09:55 | Report abuse |
  8. Dave Aifan

    WTF CNN.com? "An FDA review of Qnexa blamed "Fen" – fenfluramine – for the deaths" An FDA review of Fen-Phen, not Qnexa! Hire me as your editor. You need one NOW and I work cheap!

    July 15, 2010 at 19:34 | Report abuse | Reply
  9. dike

    These are bad times for the gov, and FDA.... hint hint.... need to pay off more for approval...

    July 15, 2010 at 19:52 | Report abuse | Reply
  10. cEnEn

    You might as well start titling articles " 2+1 =3". It's more entertaining and meaningful than all of these bias opinions stated as facts!

    July 15, 2010 at 19:52 | Report abuse | Reply
  11. dike

    Thats how the economy works... promote fast food, make bad food cheap.... in return it pays in many ways to the insurance companies to doctors to car companies that need to make bigger vehicles to move the fat around to the oil companies to support the movement of food and bigger gas guzzlers.... People even overeat at hospitals dying of second heart attack... and expect some medication to work without any side effects..... wake-up eat right and exercise.

    July 15, 2010 at 19:58 | Report abuse | Reply
    • Jessica

      I dont see why we dont just get over it already and become like the people in WALL-E, so much fun sitting (er laying) around all day eating and drinking, while robots bring you more food and drink...and you do absolutely nothing but eat and drink...ah heaven! gluttonous, wonderful, chocolate coated heaven! (end sarcastic silliness)

      July 16, 2010 at 09:59 | Report abuse |
  12. Sonia

    Finally, the FDA is doing it's job and protecting the people...not accepting the pressures of the lobbyests throwing cash around so they can make their milllions right before the products is expectedly pulled. Now if the Veterinary FDA could just ban Rimadyl for dogs....thousands have died when they can chose many many other arthritis meds instead, or pain meds post surgery. They've received hundreds of thousands of complaints over the years and they still allow it to be used!

    July 15, 2010 at 20:02 | Report abuse | Reply
  13. lj

    Good. The side effects of topomax are terrible. There's no way it should be approved as a diet drug. Not only that, it's a ONE SHOT diet drug. If you stop taking it and then start up again, it won't work. The metabolic changes are done. It's over. You've messed up the magic bullet.

    Oh... you'll still get the changes in taste i.e soda and processed foods will taste terrible but your body won't dump fat and process fat like it did the very first time you started taking the drug. So that magically weight loss of a couple pounds a week is gone forever.

    The drug works great (despite the horrible side effects) for its original purposes of migraine and epilepsy treatment but the off label uses should stop.

    July 15, 2010 at 20:05 | Report abuse | Reply
  14. CL

    Im glad to see they are not allowing this drug with Topamax to be used. I took Topamax for migraines and the side effects are not worth it, too many bad side effects outweigh the good...

    July 15, 2010 at 20:16 | Report abuse | Reply
  15. fireybuddha

    o for god's sake – just eat better food, less of it, and get off your collective asses. that's all. no drugs, no drama – just common sense.

    July 15, 2010 at 20:31 | Report abuse | Reply
  16. David

    All these drugs, surgeries, and quick fixes are sickening. What ever happened to eating right and getting off your fat butt and taking a long walk once in a while? People stuff their faces with all the garbage processed foods and drink soda pop instead of water, then they wonder why they're obese. If you take in more calories than you burn, you get fat. It's just that simple. You can't expect a quick fix to 5, 10, or 20 years of terrible lifestyle choices.

    July 15, 2010 at 20:41 | Report abuse | Reply
    • Scott

      Too many people think walking is exercise. You're already supposed to do that without effort. I know a few obese people that walk together a couple times a week, calling it exercise. I wonder if they think playing slot machines is a business plan.

      July 16, 2010 at 01:35 | Report abuse |
  17. eve2054

    at what point will people stop looking for the magic pill that will make them thin and beautiful? What ever pill they invent will always destroy your liver, or your heart or some other part of your body.

    July 15, 2010 at 20:45 | Report abuse | Reply
  18. Tom

    I have a magic bullet that helps you lose weight, it's called eating less and exercising you weak lazy bums

    July 15, 2010 at 20:54 | Report abuse | Reply
    • GMan83

      But that would cut into our "American Idol" viewing time...

      July 15, 2010 at 22:47 | Report abuse |
  19. D

    Fat is a symptom. Any drug that simply masks the symptom of a disease that will kill you and that can be prevented is unethical. That said, screw the government there are lots of dangerous drugs that are legal.

    July 15, 2010 at 20:58 | Report abuse | Reply
  20. Cathy

    I totally agree with this decision, because I take Topamax for its FDA-approved purpose (epilepsy) and I know exactly what the side effects are like. It's an amazing drug and it really works (for epilepsy), but there's a reason why it's the 3rd, 4th, or 5th drug that doctors try for epilepsy, never the first– the side effects can be horrendous. I'm one of the few who doesn't have significant cognitive and memory problems, but almost everyone else gets them. One thing they will NOT tell you is that it carries a very high risk of kidney stones. This did not really show up in the FDA trials before it was approved all that much; it came out once people started using the drug over the long time. I do have those. It's worth it for me because nothing else totally controls my epilepsy, but there's no way that taking Topamax is worth it just to lose a little weight. It's a SERIOUS drug and nobody should take it lightly.

    July 15, 2010 at 21:36 | Report abuse | Reply
    • lj

      I agree. The drug works well for its intended purposes and even then, it's usually a second or third method of treatment. When my neurologist put me on it, he did so with many, many warnings and once I was on it, he had to force me to eat because I was losing weight too quickly.

      I suffer from the cognitive side effects and I WISH I could stop taking it. They're terrible. It's horrible to go to say a word and have your brain short circuit or to try and read a book and lose your place.

      July 15, 2010 at 21:53 | Report abuse |
    • Jessica

      lj – just curious, I saw you mention above that you take yours for migraines. Did you doctors only give you meds – or did they try to determine the cause of the migraines? About 2 years ago I got a migraine that never left – for the first month, my doctor kept giving me different meds to try – I remember Midrin (didnt do anything) but cant remember the other ones. I finally had to force her to refer to me to other places – because I was ticked off that all she wanted to do was treat the symptom,not cure the problem. Finally got bloodwork done and a slew of new allergies appeared – I had no clue about them. The allergist was INSISTENT that my food allergies were not to blame – was either my tree allergies (pollen) or a sinus infection (which isnt a sinus infection, but rather a reaction to my wheat & dairy allergies it turns out). Anywho...I tried his method for a month or two...and was so frustrated that nothing was working, I decided on my own to cut all the foods out, and slowly reintrouduced them (not a suggestion by the doctor, since he was convinced foods cant cause migraines). Turned out it was my new peanut allergy. And onions (though they didnt show up on the bloodwork) were causing the severe sinus-burning headaches. Now, I just avoid those foods and rarely have any issues any more (sometimes foods are cooked in pans that may have had peanuts, or touched onions...so im not always in the clear). Just thought id share my experience in case it helps any...i know how rotten migraines are, and if the side affects are that bad – maybe it's worth looking into?

      July 16, 2010 at 10:11 | Report abuse |
  21. Anita

    For people who do not want government regulation of anything, I would suggest that you read Upton Sinclair's "The Jungle". Government regulation can be stupid, wasteful, over-reaching, but I would rather that we attempt regulation of stuff for two reasons: 1) people will make very wrong choices regardless of "labeling" and 2) corporations are capitalist by nature and will sell anything as long as there is a market. I am not against capitalism, but The Jungle is one illustration of capitalism run amok.

    July 15, 2010 at 21:40 | Report abuse | Reply
    • Scott

      As long as their choices don't infringe on anyone else's liberty or property, it should not be a legal matter. Sure, the way our society is set up, the taxpayers often foot the bill for people's mistakes. Nobody likes that. But that's a problem with our system, not freedom.

      July 16, 2010 at 01:27 | Report abuse |
  22. Ed

    I am still surprised there is a comment about "it's my body and I have my own right to take this drugs despite the forewarned side effects." People, wake up! Now there is someone telling you this new drug might cause a harmful side effect, and now if you insist on taking this drug, then, your health goes bad. What are you going to do? Most possibly you are going to sue. So, why don't you save your energy now and listen to some suggestions before you regret taking this drug and loss your life!

    July 15, 2010 at 21:49 | Report abuse | Reply
    • SurRy

      It's just like the cigarette smokers who cry about their "right to smoke". When they show up in the ER gasping for air, complaining of chest pain, bulging eyeballs and blue skin it turns into everyone's problem ($$$).

      July 15, 2010 at 23:13 | Report abuse |
  23. Greg

    If the FDA is going to legalize Topimax for weight loss, they might as well legalize cocaine for weight loss.

    I took Topimax for neuropathic pain and I felt more intoxicated than after a few beers. You can't drive on it. What's worse, it lead to a vision impairment that ended my career and left me on disability with partial blindness.

    July 15, 2010 at 21:49 | Report abuse | Reply
    • lj

      No kidding. I had to leave school because I couldn't study. Switching to another drug wasn't an option as no other drug worked. Forget driving. I haven't gotten behind the wheel in ten years. I'd probably kill someone thanks to a lack of focus.

      Diet drug? I don't think so.

      July 15, 2010 at 21:57 | Report abuse |
  24. andy29


    What ever happened to us having the right to control our own bodies? If I want to risk the side effects of this drug, then it's my body, my choice!
    That is a brave statement but when you die from the side effect of a given drug your estate will sue the FDA, the prescribing MD and the pharmaceutical company for tens of millions with the allegation that they killed you without ever advising you of the risks.....

    July 15, 2010 at 22:39 | Report abuse | Reply
  25. GMan83

    Information is lacking about proper nutrition from the day we are born in this country. People eat far too much Enriched and or Bleached flours (wheat, corn, etc), High Fructose Corn Syrup (high correlation to obesity; improperly labeled by the FDA as a natural ingredient probably cause they're paid off), Fried foods, and not enough Vegetables. We are taught from an early age that people eat what they like. With so much saturated and hydrogenated fats in these "quick", cheap foods, it's no wonder people have trouble keeping the weight off. Eat for sustenance. Quit over indulging. And exercise (preferably resistance/weight training, but cardio will suffice).

    July 15, 2010 at 22:44 | Report abuse | Reply
    • SurRy

      Exactly! Food is to fuel a body.

      July 15, 2010 at 23:17 | Report abuse |
    • Jimh77

      Most of what you are speaking about has hapened since 1970 in regards of our processed foods that is kiliing us. We need to stay clear of all , ALL PROCESSED FOODS! INcluding ANY AND ALL FAST FOODS! So many peple have no idea what they are eating or feeding their famlies. That outting to the fast fod giants. We need to educate parents first. Out Govenment refuse to di it. So , it is up to us to inform Americans what is safe to eat. Unless you grow it, don't eat it!!

      July 15, 2010 at 23:54 | Report abuse |
  26. Jimh77

    And they allowed Advantia to be continued after all of the data... Dr death must still prevail....

    Would you like a little Soylent Green with that?

    July 15, 2010 at 23:18 | Report abuse | Reply
  27. E

    I guess pockets weren't lined, so they voted NO. Maybe it money changed hands, they would have said YES!!!

    July 15, 2010 at 23:47 | Report abuse | Reply
  28. Gpenn

    Yea this is the government depriving you of a drug that you people should have the right to decide if you want to chance the side effects or not. Give me a break. You clowns would be lining up to sue right after you yelled at the government for not protecting you when something goes wrong. If there was any doubt about the public needing to be protected. That should be laid to rest after reading the ridiculous comments right here. And to the internet instant experts on here, just stop. The majority of you have no clue what your talking about, so just stop it. Just because you can google something doesn't mean you know what your talking about.

    July 16, 2010 at 00:16 | Report abuse | Reply
  29. jennyisdead

    As a former junkie, I actually have to agree with the FDA. Yes, the government should not be making all our decisions, but how many people actually take the time to research what they're ingesting, let alone give any thought to multiple drug interactions? Think your doctors know everything about the drug they are prescribing? What a joke. In my personal experience they're just as much in the dark as you are. Only YOU know your body best. Look out for yourself. However, we also must understand that a good majority of people blindly accept what is handed to them without question because that's what we are trained to do from birth. Honestly, I don't see much of a difference these days between street dealers and MD drug pushers/pharmaceutical companies. People...if it has the word amphetamine is involved, you're gambling with your life, which is why I find it absolutely appalling kids are taking Adderall. Just wait a few more years for the long term effects to show. And btw, I find it interesting that as the drug ads have increased over the years, the more "mentally ill" we have become. You are what you believe you are, and these drug companies certainly want you to believe you are flawed and have a serious problem. Bring me back to the days when none of my friends were on Zoloft and A.D.H.D. meds. I'm not going to deny that medications can and do help with certain types of depression, etc, but I also believe that people see these ads and then subconsciously their bodies start mimicking symptoms. The mind is sneaky.

    July 16, 2010 at 00:39 | Report abuse | Reply
  30. Scott

    All drugs should be legalized. Whether it be a diet drug, trans fat, or crystal meth. I own my body. Not the government, not the voters, and not you. As long as the company producing the drug informs of possible side effects and risks, that should be enough. When someone takes the drug knowing the risks, that's their own responsibility. I already know the counterpoint is concern that people making poor health choices will raise the cost of healthcare for everyone. That's why you probably shouldn't endorse healthcare legislation forcing all Americans into the system. Let people live and pay for their own lives.

    July 16, 2010 at 01:17 | Report abuse | Reply
    • chiquita

      Its your body, but if you mess it up "I" pay for it. You go to the ER, you skip on your bill, I pay. You end up with life long problems due to these pills, incur astronomical health costs, these costs get spread out by insurances and "I" pay a higher premium for your stupid mistakes. If its "YOUR" body, "YOU" fix it the right way. Shortcuts cost others. Stop eatting fast food 5 times a week.

      July 16, 2010 at 10:44 | Report abuse |
  31. Jimmy

    Skip the diet drugs and go after long term results with something like BodyMedia FIT (www.bodymedia.com) where you focus on the fundamentals of what impacts your diet. Food, Sleep, and Activity. The product unlocks the secrets of your body with real results. People lose up to 3X more weight using the system. Pretty amazing for not having to take a pill or do a crazy diet or workout plan.

    July 16, 2010 at 03:49 | Report abuse | Reply
  32. IronRider

    Guess this is one pharmaceutical company that couldn't afford to payoff the FDA or their local senator!

    July 16, 2010 at 03:54 | Report abuse | Reply
  33. Fauz

    Its surprising to see the FDA doing their job, considering the ridiculous amount of products they DO approve which should NOT be approved.

    July 16, 2010 at 04:38 | Report abuse | Reply
  34. Slim

    Pharmaceutical drugs make people fat, depressed and sick. Period.

    July 16, 2010 at 04:40 | Report abuse | Reply
  35. AJ

    When making these decisions on new drugs, there are 2 very important formulas that the FDA and drug companies calculate.

    One is: "Number needed to treat" – which is a calculation that says, X number of people would need to take the drug for it to benefit 1 person.

    The other is: "Number needed to harm" – it's another calculation that says, X number of people would need to take the drug for it to harm 1 person.

    Sometimes, the number needed to treat is like >100, but the number needed to harm is <10, i.e. if 100 people took the drug, 1 person would benefit and 10 people would be harmed. In good conscience, how can someone pass drug?

    There are exceptions, like chemotherapy drugs, in which the patient population is very small, and the disease very deadly, that the risk-benefit ratio is skewed that even though the number needed to harm is far greater than the numbered needed to treat, the drug is still acceptable.

    July 16, 2010 at 08:34 | Report abuse | Reply
  36. laurie

    As a middle aged, hormonal fat girl myself, I know my opinion is pretty unpopular among the non fat bashing set but really....fat is about food in and energy out. A lot of people blame their hormones, their thyroids and every other thing they can latch onto to justify their behavior. I am glad the FDA voted this down. They should vote every weightloss med down. Weightloss is not a pill. Its work and in there lies the problem. We in the US are lazy and spoiled and we will use any excuse in the book and take any pill you give us just so we dont have to do the hardwork.

    But I believe in the reward of that hardwork. And really, are we doing our children a service by making fat fashionable and the new norm? NO...we are sending them to an early grave!

    FDA got this one right but probably not for the reasons we wish they did.

    July 16, 2010 at 08:41 | Report abuse | Reply
    • Complex


      The "making fat fashionable" comment, as a "self-proclaimed" fat girl – was way off base. As a normal sized person trying to further promote a healthy self esteem in young people, it is thinking like this that is such a dis-service to everyone, but especially the obese population. The hope for this type of "movement" is that when people feel better about themselves (big or small), they will take more interest in their health and fitness and have the motivation to improve their health/weight. Demeaning and berating DOES NOT WORK! Exclusion DOES NOT WORK! I am a size 4/6, and I work with young people to promote a healthier self esteem so that drugs like this WILL NOT be necessary when they get older. The old ways of thinking are not working! That is why the obesity rate IS so high. Groups like Hardy Girls, Healthy Women are showing that there is a way to do this differently! (I am not affiliated with them in any way, but they are a great example of how to reach people in a POSITIVE and UPLIFTING way).

      July 16, 2010 at 12:45 | Report abuse |
  37. memo2

    We need to write to our Congress and stop this insane practices from the FDA.
    What is going to be next.

    July 16, 2010 at 09:07 | Report abuse | Reply
  38. Dipping for life

    The best way to diet is to have pills that kill the fat people.. Thank goddness for FDA to save us all.

    July 16, 2010 at 09:12 | Report abuse | Reply
  39. Kate

    If you can't cut the amount of food you eat, you don't want to lose the weight bad enough. You have to work for what you want. You cannot use pills as a crutch. Portion control is the key. CONTROL is the key word.

    July 16, 2010 at 09:17 | Report abuse | Reply
  40. Paige

    As an epileptic who took herself off of the medicine (I would rather suffer seizures than Topamax)- I can attest to the fact that this drug should not be marketed for anything but neurological disorders. Even with the condition for which this drug was originally designed, I had memory loss and slower mental function (something that can cost you your job wen you work in contract analysis as I do)as well as very real suicidal thoughts- not to mention vision trails that were on par with tripping. The FDA did the right thing- this is too strong a drug to be used cosmetically.

    July 16, 2010 at 09:20 | Report abuse | Reply
  41. Joy

    David wants the right to control his own body in taking dangerous drugs. It'sbecause of brainless people like that why we have the "no drinking and driving laws".

    July 16, 2010 at 09:37 | Report abuse | Reply
  42. Diane

    I think the FDA hit this one on the head. Taking dangerous drugs to lose weight is not a good idea. Get out and exercise it will help you lose weight your health will improve. Parents need to make sure their kids are out doing some sort of activity that will help with their weight and health. Sitting in front of a video game all day is why our children are obese.

    July 16, 2010 at 10:09 | Report abuse | Reply
  43. davidinohio

    When will people learn that there is no magical pill? So what is the best weight loss drug? Here it is, are you ready? Exercise between 30 minutes to 1 hour (once or twice a day). Eat five servings of fruits and vegetables, if you eat meat, eat around 5oz. Stop drinking pop/soda, cut milk intake, drink more water. Cut out the sweets. There, no side effects and you lose weight correctly and it's free.

    July 16, 2010 at 10:12 | Report abuse | Reply
    • LAB1972

      But exercise and proper food intake requires people to be held responsible for their condition. Gawd forbid. You are definately right, davidinohio. There may truly be some folks with legit medical problems that affect their weight, but I think the fact that the growth of obesity problems and the growth of the fast food/large portions industries is a big giveaway to what the real problem is.

      July 16, 2010 at 10:39 | Report abuse |
  44. bigbadape

    My wife was on Topamax and lost lots of weight, but at a huge price. People who use Topamax call it Dope-amax for a reason. It made her stupid, she almost lost her job.

    July 16, 2010 at 10:22 | Report abuse | Reply
  45. A. Goodwin

    As a parent of a child who is an epileptic, I honestly think this is a GOOD thing. Topomax is a very SERIOUS drug with MANY side effects. My son was on it less than a week before we took him off of this drug. I myself have to WORK hard to keep fit. My mother is obease (300+ pounds) and I once was 200 pounds. The only thing that truly works is diet and exercise. There is not magic pill that can make you thin – only lots of motivation and resistence to overeating. I hate working out, but I do it for the good of my health...and so that I can keep up with my son and daughter. This is part of having bad genes – you got to work for it.

    July 16, 2010 at 10:35 | Report abuse | Reply
    • chiquita

      It takes 4-6 weeks for the effects of the drug to kick in. Taking him off less than a week in was not due to Topomax, could have been something else.

      July 16, 2010 at 10:38 | Report abuse |
    • A. Goodwin

      Not true. Yes, it takes 4-6 weeks to work up to the FULL DOSAGE of any seizure medication. However, if you are having serious side effects from any anti-convulsant you should remove yourself from the drug (in concert with working with your neurologist) PRONTO!! If you are having major liver/kidney function issues due to Depakote, you would not certainly CONTINUE to take the drug until you no longer have those side effects...not unless you want to die. That is why they WORK UP to full dosage. If you are having serious side effects say after taking 1 ml. of Zerontin...you wouldn't take more. You would simply have to find a different drug to try. Serious side effects do not mean a little irritability to the tummy or a little numbness in the fingers – we're talking about ER visits..

      July 16, 2010 at 10:54 | Report abuse |
    • chiquita

      In the first week, you are supposed to be SLOWLY working your way up in dosage (depending of course how much your DR thought you needed in total). In a couple days of the startup period, I can't imagine what would make you go to the ER. Items critical to health take much longer to develop. Not sure why you are talking about Depakote & zerotonin, when Topomax is at discussion. Over a couple days, at tiny dosages, I'd blame something else, my opinion. Kidney/liver damage happen from long term use, not couple days.

      July 16, 2010 at 11:05 | Report abuse |
    • A. Goodwin

      Sorry – I assumed you were an epileptic. The other drugs I mentioned are for seizure disorders – several in the same "class" as Tompmax. Just trying to get my point across that these drugs DO have serious side effects that can happen at VERY low doses. My son took the drug for a total of six days at the lowest levels and ended up in the ER as he was disoriented and vomiting and it was NOT the tummy flu. After two days on the drug he started gagging uncontrollably. By the third and fourth days he was acting lucid, had tummy pain, vomited several times. By the sixth day we had enough, took him to the ER...that day we stopped giving him Topomax. I think you are sadly misinformed if you honestly believe that items critical to health take longer to develop when it comes to SOME drugs.

      July 16, 2010 at 11:24 | Report abuse |
  46. chiquita

    Topomax is used for both seizures and migraines. Only 40% of people on it loose weight, the other 60% GAIN weight. How do I know? I took topomax for 3+yrs and was one of the gainers, and hence did my research. Topomax is horrible, causes kidney stones. It makes you "loopy" totally space out, like you are in a day dream ALL THE TIME. I drove my car and couldn't concentrate, it make me stare out the side window instead. Horrible. I understand Pharma is after profits, while they have current patents. But why is the FDA allowing this to happen? Perhaps someone there is getting paid to approve, cause I can't imagine another reason!

    July 16, 2010 at 10:37 | Report abuse | Reply
    • A. Goodwin

      If you are an epileptic (definition: more than two seizures in your lifetime) than you should seriously consider NOT driving a car. Even if you RARELY have them. HTH.

      July 16, 2010 at 10:56 | Report abuse |
    • chiquita

      I took topomax for migraines, not seizures. You can drive safely with a migraine,but with topomax, not so sure

      July 16, 2010 at 11:00 | Report abuse |
  47. Leah (TXanimal)

    It's possible that the real concern is that the users of this particular drug will simply overdo it? "The recommended dosage is 1capsule, so if I take 4, that'll make it work even BETTER!!!". Maybe the risk is not in the Topamax itself, but in the risk of taking too much at one time? Granted, this is PURELY ANECDOTAL and I could be completely wrong, but it's just an observation: I used to work as a personal trainer and I compete as a bodybuilder. I can't tell you the number of people who would buy Hydroxycut, Meltdown, or other OTC "fat-burners" and take 3 times the recommended dosage, binge drink, skip meals and drink 2 pots of coffee during the day. OF COURSE things like your liver, kidneys and heart will suffer!

    July 16, 2010 at 10:42 | Report abuse | Reply
  48. Mo

    Hmmmm, strange, I take phentermine AND topomax and I don't exercise or watch what I eat and I have been losing weight consistently. It has been a miracle drug combo for me and it has been the only thing that has worked. I have tried Weight Watchers, Curves, Jenny Craig, just about everything, and this is the simplest way for me to lose weight.And I haven't had any of the side effects. Been on it for 22 months now.

    July 16, 2010 at 10:55 | Report abuse | Reply
    • Inkt1

      Remeber this sarcasm when your doctor tells you your liver and/or kidneys are shot...

      July 16, 2010 at 10:58 | Report abuse |
    • Sheona

      Try self control!

      July 16, 2010 at 12:02 | Report abuse |
  49. Inkt1

    To everyone using the "chemical imbalance" excuse regarding their lack of ability to lose weight: In most cases the initial reason for your "chemical imbalance" is not eating right and sitting around all day. You've got to eat CLEAN, eat the RIGHT CARBS (high fiber, low sugar–think brown not white) LEAN protien from a VARIETY of sources (nuts, lean meat, BEANS!!, cottage cheese, soy) and, for goodness sake EAT YOUR VEGETABLES!!! Eat 5-6 meals per day (once every three hours) to keep blood glucose levels on an even keel. I like a ratio of 20/60/20 protien/carb/fat. And you've GOT to exercise HARD at LEAST 4-5 hours per week and keep it interesting-explosive cardio, distance cardio, weight lifting, yoga/stretching. If you make these changes GRADUALLY so that each little change becomes part of your everyday life it isn't sooooo overwhelming to do this. After even 90 days of living this way you will realize that all these excuses are just that - EXCUSES.

    July 16, 2010 at 10:55 | Report abuse | Reply
  50. Lee

    It is sad that people want to take medication in for their obesity problem rather than dieting and exercising properly. "Let me eat my twinkies, I'll just take a pill."

    July 16, 2010 at 11:00 | Report abuse | Reply
    • Sheona

      It is sad how lazy we are. And then blame 'others' when pills make us sick. Lazy and irresponsible.

      July 16, 2010 at 12:15 | Report abuse |
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