June 2nd, 2010
10:38 AM ET

Spray may treat premature climax

By Elizabeth Landau
CNN.com Health Writer/Producer

It's fitting that "PSD502" sounds like a code name, since it relates to a distressing problem most men would prefer not to talk about: premature ejaculation.

Researchers recently presented findings on PSD502, a topical spray medication, at the American Urological Association Annual Meeting. The spray, made by pharmaceutical company Shionogi Pharma, Inc., is in trials among men who suffer from premature ejaculation.

Participants were selected from 70 centers in the United States, Canada and Europe to use either this spray or a placebo spray. They were told to put the spray on the glans penis - the conical structure at the tip of the penis - five minutes before intercourse. Data came from two studies, each of which had more than 500 men.

Researchers found great improvement, with an average time of 3.3 minutes to penetration and climax among those who used PSD502, representing a 5.5-fold increase over the baseline of 36 seconds. Participants who used the placebo had a 1.6-fold gain in time to ejaculate.

The spray itself does not work magic with new materials; in fact, it is a combination of two drugs currently on the market for pain relief: lidocaine and prilocaine.

The company is in the process of applying for approval from the U.S. Food and Drug Administration and could not yet estimate when the product might be available to consumers.

There is currently no FDA-approved treatment for premature ejaculation.

Between 5 and 30 percent of men experience premature ejaculation, studies have found. Risk factors for premature ejaculation include erectile dysfunction, stress, other health problems and use of certain medications such as psychotropic drugs.

Learn more about premature ejaculation from the Mayo Clinic.

Editor's Note: Medical news is a popular but sensitive subject rooted in science. We receive many comments on this blog each day; not all are posted. Our hope is that much will be learned from the sharing of useful information and personal experiences based on the medical and health topics of the blog. We encourage you to focus your comments on those medical and health topics and we appreciate your input. Thank you for your participation.

soundoff (139 Responses)
  1. omar

    Tracy, the best assistance that can be provided for women's sexual dyfunctions is to provide men with better, more explicit and taboo free sex education.

    June 3, 2010 at 00:45 | Report abuse | Reply
  2. brad1001

    Wow, 36 secs. And as young men we used to hoot about a "2 minute" man. I guess that would be a drag to go so quick.

    June 3, 2010 at 00:53 | Report abuse | Reply
  3. Stephanie

    Jesse, are you seriously comparing premature ejaculation to breast cancer?

    June 3, 2010 at 00:58 | Report abuse | Reply
  4. ricker

    this is news? medical companies are just looking for a way to get in on the action, then welcome in insurance companies to exploit the matter offering the $300 patented product to the user via healthcare for $50. IN THE MEANTIME, head over to your local deli/tobacco store and pick up STUD 100 for $10. Lidocaine 9.6%, 'male genital desensitizer'

    June 3, 2010 at 01:01 | Report abuse | Reply
  5. Charlie

    You can do this now. lidocaine is the active ingredient in Chloraseptic throat spray.

    June 3, 2010 at 01:20 | Report abuse | Reply
  6. matt


    Aids, cancer, heart disease, stroke, etc.
    And these scientists are working on this?
    Oh, the world we live in.

    June 3, 2010 at 01:29 | Report abuse | Reply
  7. Mike

    How about everyone stop busting the american man's balls?
    I have to work, fight wars, sift through corrupt government, protect you and pay for everyone on the dole. Show me some awareness, consideration and lighten up and maybe we'll be there for you ... longer.
    Satisfy the man and he'll satisfy the woman and vice versa.

    June 3, 2010 at 01:33 | Report abuse | Reply
  8. Nathan

    I think its odd that everyone is talking about numbing the glans of the penis but no one is talking about the real underlying problems that can very easily cause premature ejaculation such as age, sexual experience, intact status, stress, level of closeness with one's partner, psychological and physical health.

    June 3, 2010 at 01:34 | Report abuse | Reply
  9. Jack

    Actually, there is pharmaceutical company is on the final stage for treating women sexual dysfunction. It's called Libigel. I believe it BioSante pharmaceutical. Do some research.

    June 3, 2010 at 01:39 | Report abuse | Reply
  10. Cy

    I think the whole premature ejaculation directly is related to your partner and how sexually compatible you are together.

    I have been with women that made me have orgasms one after another. I also been with women that caused me have premature ejaculation or Erectile Dysfunctions.

    My conclusion is the less you care about somebody, the better sex you'll be having. Sex with girlfriends and wives become routine and boring.

    June 3, 2010 at 02:32 | Report abuse | Reply
  11. GBM

    Both Barry and Tracy have good comments.

    Barry is going in the right direction. I bellieve that premature ejaculation is a social conditioning and myth. We have been told endlessly that the orgasm is the end/goal and once reached we have been taught to just stop and not even try to continue.

    If men simply continue on they will find that multiple orgasms are more typical than not.

    As Tracy points out there are probably not enough women who are enthused about prolonged sex for all the men taking ED drugs. The whole concept simply plays to men's fantasies.

    June 3, 2010 at 02:41 | Report abuse | Reply
  12. OS

    My problem is latent ejaculation, especially when i'm drunk. As for Tracy's comment, men are having sex with women without sexual problems. It's unfortunate, but the majority of women seem to have some kind of sexual hang up. That's why we stick to the few women who do climax easily.

    June 3, 2010 at 02:44 | Report abuse | Reply
  13. Robear

    Premature ejaculation can be controlled, and with practice (and a supportive partner) many men can overcome that problem. But it's all relative. I used to think that reaching climax under 5 minutes WAS premature!?!? But at 36 seconds, why bother having intercourse at all?

    June 3, 2010 at 03:04 | Report abuse | Reply
  14. Thomas

    Tracy and Zoe,
    Since the female is largely a mental phenomenon, I'd suggest that the women who want help in the sack should look less at science for help and look more at themselves. Get a therapist if you want help. We all know that us men are rather simple, visual and physical creatures in the sex dept, which would explain why science has had more success in dealing with men's issues. You shouldn't try to compare the two. It is what it is.

    June 3, 2010 at 04:30 | Report abuse | Reply
  15. Joe

    How was the study conducted? Do they take into account different partners? Is their an observer? Are the females consistant variables? Are the females participants for the experiment as well? I am genuinely interested in these questions, I almost never see it answered in sex studies like these.

    June 3, 2010 at 05:57 | Report abuse | Reply
  16. Francis

    There's lots of help available for women with sexual dysfunction. It's called a psychiatrist. A woman can always have sex. The problem is she often doesn't want to. If a man can't get an erection, or ejaculates too fast, then sex is not going to happen. Maybe that's why there are more drugs available for male sexual problems. Men's sex problems are normally physical, women's sex problems are normally psychological. Tracy tell us your problem?

    June 3, 2010 at 06:49 | Report abuse | Reply
  17. Chadrin

    Half of a minute.. you would think a person does not want sex?
    (get it over with and go watch tv). Tracy and Zoe, you may be correct, but for a different reason.

    I would foresee that this product, regardless of effectiveness will still have a market and succeed in sales. Seeking endorsement from an association makes business sense. It can be the difference between sold in pharmaceutical isles vice adult bookshops. Realistically, Many more customers frequent a pharmacutical than adult shop. It is Ad Placement!

    June 3, 2010 at 07:05 | Report abuse | Reply
  18. JMAC

    Ok look this is a two way street here yes its not fair how so much comes out of researching for men like Viagra and Cialis and now this new PSD502 and that it has taken forever for women to get an effective birth control pill and hardly anything to make sex better for women but think of it this way how enjoyable is it for a female to have sex with a man who cannot get erect and if the man can get erect how aroused or close do you get to climax when he finishes the race way before you its not so much of men thinking just about themselves but trying to make it better for both parties

    June 3, 2010 at 07:08 | Report abuse | Reply
  19. Tim

    The main problem for women with regard to sexual dysfunction is a lack of sex drive. Never met a woman that had much of one. If they made a "Horny" Pill for the ladies, there'd be no war.

    June 3, 2010 at 07:38 | Report abuse | Reply
  20. Kabel

    I just wish that they would find some form of Viagra for Women. My wife's sex drive is so low, we only have sex maybe once of twice a year. It has caused some serious issues with our marriage, even to the point where both of us have strayed. Fortunately we were able to get by that, at least as far as I know. 🙂 We have been married for 18 years and I love my wife so much, but it does drive a wedge between us with her low labito. I mean having sex twice in the last 18 months is not normal and for me at least it makes me wonder what is wrong with me. It makes me wonder if my wife is no longer in love with me or maybe I disgust her or maybe I am no good in bed, all things which drove me to another woman once, but upon cheating on my wife, I got nauseated, sick, and depressed and immediately confessed to my wife only to find out that she had done the same thing, because she was wondering herself why her sex drive was so low.

    So it's great that they are doing something to make sex last longer for men and women, but it would really be nice if they could help those of us with little or no sex drive.

    I know some people think sex is not a big part of marriage or a relationship, but it really is.

    June 3, 2010 at 09:16 | Report abuse | Reply
  21. Clinton

    let the researchers and everyone figure it out. If you can help that one person out there, or countless others then great. And yes woman may need help too OR maybe the help will come with new developing research. Tracy be patient girl, your man will come thru soon

    June 3, 2010 at 09:40 | Report abuse | Reply
  22. OS

    Kabel, that's Darwin at work. Either you two weren't meant to have a lot of sex, or you weren't meant to have a lot of sex with each other.

    June 3, 2010 at 11:58 | Report abuse | Reply
  23. Zoe

    Kabel, I encourage you and your wife to give Zestra a try – it’s an over-the-counter product that is clinically proven to increase a woman’s feeling of desire and arousal.

    June 4, 2010 at 16:50 | Report abuse | Reply
  24. marla

    Just another attempt to aid men. I am tired of going to the candy store and getting nothing.

    June 5, 2010 at 23:47 | Report abuse | Reply
  25. Jesse

    @ Patti and you will be singing a very different toon when someone you love is diagnosed with rectal cancer and nothing c an be done because all the funding went to breast cancer research because rectums just aren't sexy like breasts. Is it really fair to condem people to death because they get cancer in a not so sexy spot?

    @ Stephanie no i was responding to people saying there is an unfair bias in sexual disfunction research as it pertains to men and women. If when they find a cure for a male sexual dysfunction the frist comment out of some peoples mouths are thats not fair they don't do anything about female sexual dysfunction, my response is to look at the discrepancy between breast cancer research, and cancer research for every other part of the body. But because you have breasts tahts ok right?

    June 6, 2010 at 18:15 | Report abuse | Reply
  26. Henry Barnes

    Mens issues are sometimes always concentrated on the ego of men.*;:

    July 9, 2010 at 11:59 | Report abuse | Reply
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    men's issues are always about money, career and women. those sort of things.:`-

    July 26, 2010 at 11:52 | Report abuse | Reply
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    Wow,,, thanks to you Dr s. Muzack, for your wonderful product that has really saved my marriage, after suffered from Erectile Dysfunction and premature ejaculation for 15 months which I thought I could never be treated from, but you have made me believe what they said about you and your herbal products, it real work like magic as they really said about the drugs. I just want to use this opportunity to share to those that are having similar issues in their marital Sexual life, please my audience inability to satisfy your wife sexually are the major reasons why many marriages fail today, it is your responsibility as a man to always satisfy your wife's when ever she needs you, always be active and stops all your unnecessary excuses, be the man you really are, to save your marriage. What really burst my Sexual ability was the herb product i got from Dr S. Muzack. I was on the internet one faithful day when I saw a testimony on how Dr muzack herbal products treated him from premature ejaculation and ED, I was so amazed at the testimony because it was what I was facing in my Sexual life too, with the email on it, I was able to contact him directly, that was how I got the product fast and easily, the very day I started taking the medication result follow immediately, I'm now stronger than ever, you too can be,,, this was how I got his email after a written testimony, you can still have it here.
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