February 4th, 2010
09:58 AM ET

Autism study triggered parents’ fears

By Miriam Falco
CNN Medical Managing Editor

At 9:01am on Tuesday, journalists around the world got the news: The British medical journal Lancet had decided to "fully retract" a study it had published in 1998. The study was conducted by Dr. Andrew Wakefield and suggested that the combination vaccine against measles, mumps and rubella (aka German measles), also known as the MMR vaccine, triggers gastrointestinal problems, which may trigger autism.

It was a very small study – only 12 children were in it. But it was the study that was heard around world because it triggered a fear in parents that vaccines may cause autism. Consequently, many parents stopped vaccinating their children.

Wakefield has said his study didn't say vaccines cause autism. He wouldn't talk to the news media Tuesday, but in a written statement sent to CNN, Wakefield said "the Lancet paper does not claim to confirm a link between the MMR vaccine and autism."

Technically he is correct. In the 1998 study, Wakefield and his 12 co-authors write "We did not prove an association between measles, mumps, and rubella vaccine and the syndrome described." But the conclusion of his study says "We have identified a chronic enterocolitis [infection of the intestines] in children that may be related to neuropsychiatric dysfunction. In most cases, onset of symptoms was after measles, mumps, and rubella immunization. Further investigations are needed to examine this syndrome and its possible relation to this vaccine."

So the study suggested that the MMR vaccine causes gut problems and these gut problems cause autism.

Suddenly many pediatricians and public health officials had to convince parents about the importance of utilizing the means to prevent some very deadly diseases.

Over the past decade, the repercussions of parents refusing to vaccinate their children because of the 1998 Wakefield study were big.

- In the United States, more cases of measles were reported in 2008 than 1997. The Centers for Disease Control and Prevention says "more than 90 percent of those infected had not been vaccinated, or their vaccination status was unknown."

- In Britain, where the study was conducted, the Health Protection Agency says 177 cases of measles were reported in 1997- in 2008 the nation had 1,370 cases.

- In Germany, the incidence among children under the age of 1 year was higher in 2006 than in 2001, according to the World Health Organization.

The latest CDC statistics tell us that an alarming 1 in 91 children in this country have some form of autism.

However, WHO statistics remind us that children are dying from the illnesses that vaccines are meant to prevent. For example, measles kills 164,000 children annually, noting that "measles is one of the leading causes of death among young children even though a safe and cost-effective vaccine is available."

As a journalist who has covered autism stories for the past 10 years, I was surprised that it took so long for the Lancet to retract the study. That's because this particular study had been under fire for a long time.

Wakefield's suggested link between has been scrutinized many times in the past 12 years. In 2004, the Institute of Medicine reviewed existing research and found no evidence that the vaccine causes autism. But it wasn't the alleged link between vaccines and autism that lead to the retraction of the study this week.

Also in 2004, 10 of the 13 co-authors had their names removed from the study, when it became known that Wakefield hadn't disclosed information about a serious conflict of interest he had while running the study. He didn't disclose that he had had been paid by a law firm that intended to sue vaccine manufacturers.

Last week, a long investigation by the Britain's General Medical Council, the body that disciplines doctors, concluded that the way this study was conducted was "unethical," "dishonest" and "misleading." The board found that some of the children were given colonoscopies, MRIs and spinal taps that weren't needed from a medical standpoint. All these procedures come with some serious risks and should be done only when absolutely necessary.

Dr. Richard Horton, the editor-in-chief of the Lancet, told me that the journal had been waiting for the GMC's investigation to conclude and that after reading the 140-page report, he thought it was "the most appalling catalog and litany of some the most terrible behavior in any research" and is therefore very clear that it has to be retracted." The decision to retract the study was made the soon afterwards.

In his statement to CNN, Wakefield said, "The allegations against me and against my colleagues are both unfounded and unjust and I invite anyone to examine the contents of these proceedings and come to their own conclusion."

Does the removal of this study from the public record change your mind about a possible link between vaccines and autism?

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soundoff (12 Responses)
  1. Mandi

    My child displayed autistic characteristics before his MMR vaccine (which I put off because of the autism/vaccine fear) So when I argued with a parent in the autism community that vaccines did not cause my son's autism, she said that his Hep B shot (given at birth) probably did trigger his autism. I was still not convinced. This news about Dr. Wakefield does not suprise me.

    February 4, 2010 at 12:14 | Report abuse | Reply
  2. Angie

    As the mom of a daughter with Asperger's Syndrome, I am incredibly frustrated by the scam artists like Wakefield who take advantage of parents' desperation to sell them dangerous and ineffective treatments like Lupron (chemical castration!), chelation (which has killed at least one autistic child), GFCF diets (leading to bone loss), and innumerable supplements.

    Vaccines didn't harm my daughter - she showed subtle signs of AS as early as 4 months. Furthermore, she's almost an exact copy (personality-wise) of her father and grandmother, both of whom probably have AS, too. Why is it so hard to understand the science here?

    February 4, 2010 at 18:01 | Report abuse | Reply
  3. John

    I occasionally see scientific studies and popular press stories that I suspect were funded by lawyers seeking to build case action lawsuits. This is only one example. It is interesting that Dr. Wakefield is facing severe penalties from the General Medical Counsel (similar to our state boards for health professionals), but the lawyer(s) who paid him for research are facing no such professional censure.

    February 4, 2010 at 19:28 | Report abuse | Reply
  4. rc

    I was always skeptical of a link between the vaccine and autism and most parents should have been too. The problem is that most people lack basic science literacy – they don't understand how to read or interpret scientific data or critically assess the findings. They rely on distorted news reports to give them their information and they treat science as the holy grail; as if everything is factual and proven beyond a shadow of a doubt. It rarely is.

    It would be very helpful if these basic skills were taught in school in order to prevent the findings of these studies from being misinterpreted and exaggerated.

    The Lancet was right not to retract it 10 years ago – it's up to science to rebuke the findings. And they're right to retract the study now knowing that the doctor's affiliations and procedures may have tainted his scientific objectivity.

    February 7, 2010 at 17:33 | Report abuse | Reply
  5. Diea

    As a woman who is about to become a first time mother, my husband and I have done extesive research on the issue of vaccines and autism. Frankly, this study just did not make sense to us. The MMR vaccine has been around for decades and now it is creating a problem? It was just not based on good science. I am relieved that I no longer have to go into a long dissertation about why we will be vaccinating our child.

    February 9, 2010 at 11:49 | Report abuse | Reply
  6. brein

    I am happy to see that the mainstream media is finally reporting this story based on some solid scientific evidence and not interjecting any false balance as we have seen the past few years. It is also nice to see the comments on the majority of these stories largely in favor of science and reason. Hopefully the tide will swing back in favor of getting these kids back on a regular vaccine schedule based on science not fear mongering and ideology.

    February 19, 2010 at 11:10 | Report abuse | Reply
  7. Evelyn Ahmed

    there is still no permament solution for autism. we just have to take good care of the kids who are suffering autism."-*

    June 28, 2010 at 23:44 | Report abuse | Reply
  8. Florence Mills

    there has been no permanent cure for autism yet but i think stem cells could also help`-'

    August 29, 2010 at 14:23 | Report abuse | Reply
  9. Lexi Adams

    mumps is so damn painfull that i don't wanna hear about '–

    October 5, 2010 at 05:17 | Report abuse | Reply
  10. Socket Set

    i have a brother that is autistic and we love him so much and gave all of our support on him ,,*

    December 4, 2010 at 02:35 | Report abuse | Reply
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