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February 24th, 2014
04:07 PM ET

Acetaminophen in pregnancy linked to 'ADHD-like behaviors'

Doctors frequently recommend acetaminophen, commonly found in over-the-counter pain relievers including Tylenol, to pregnant women for treating mild pain.

But a new study out of Denmark suggests the use of acetaminophen during pregnancy could be associated with ADHD-like behavioral problems in children.

“(Pregnant women) shouldn’t worry at this point,” says study author Dr. Beate Ritz, professor and chair of the epidemiology department at the University of California, Los Angeles Fielding School of Public Health. “But if I were a woman who was pregnant ... I would try to avoid taking painkillers as much as I can until we know more about this.”

The study, published Monday in the medical journal JAMA Pediatrics, analyzed data from more than 64,000 children enrolled in the Danish National Birth Cohort study between 1996 and 2002. Mothers in the cohort study reported on their children’s behavior, and the researchers looked at databases to determine how many prescriptions for ADHD drugs were written and how many children received a diagnosis of a severe form of ADHD called hyperkinetic disorder, or HKD.

The study authors concluded that prenatal exposure to acetaminophen may increase the risk of a child being diagnosed with HKD or being prescribed ADHD medications and “exhibiting ADHD-like behaviors." It's important to note that ADHD-like behaviors are not the same as having ADHD.

An accompanying editorial published in JAMA Pediatrics emphasizes that the study has found “an interesting observed association,” but that the researchers did not find that acetaminophen causes ADHD. The study authors agree that their results do not show a cause-and-effect relationship.

The data suggests that taking acetaminophen for longer periods and later in pregnancy is associated with higher risks, Ritz says. When women reported use for 20 weeks or more, their children had a 50% increased risk for receiving ADHD medication, according to the study.

Ritz says more than half of all mothers in the study reported some acetaminophen use while pregnant. The study measured how many weeks the mother reported taking any amount of acetaminophen but did not take the dosage into account.

“When used as directed, Tylenol has one of the most favorable safety profiles among over-the-counter pain relievers,” said McNeil Consumer Healthcare, the maker of Tylenol. “We are aware of the recent JAMA Pediatrics study; however, there are no prospective, randomized controlled studies demonstrating a causal link between acetaminophen use during pregnancy and adverse effects on child development."

The study’s authors suggest that acetaminophen may increase the risk of ADHD by interfering with maternal hormones that are critical for fetal brain development, citing a previous study done using acetaminophen in rats and a study of acetaminophen and autism done with humans.

“The cited literature is not relevant to the human condition,” says Dr. Max Wiznitzer, pediatric neurologist and associate professor at Case Western Reserve University School of Medicine. “I’m afraid that (women) will think, somehow, that they caused their child’s problem when the study does not tell us that. It tells us that they are linked but does not tell us how.”

“There are a lot of variables that still need to be considered, such as the fact that ADHD runs in families,” Wiznitzer says. Seventy to 80% of ADHD cases are hereditary, he says.

The study highlights the importance of not taking a drug’s safety during pregnancy for granted, the accompanying editorial points out.

“There are nonpharmacological ways to deal with pain,” says Dr. Jeffrey Chapa, head of maternal-fetal medicine at Cleveland Clinic Children’s Hospital. Massages, baths and acupuncture are some alternatives he suggests to help relieve pain. “I think we have to focus a little bit more on that as opposed to just medications.”


soundoff (66 Responses)
  1. Vet292

    Interesting how the timeli e correlates between the explosion in ADHD and Autism, and the movement to 'aspirin is bad, every combination drug must have acetaminophen in it" in the last 20-30 years.

    February 24, 2014 at 17:00 | Report abuse | Reply
    • snoozical

      Wellll aspirin is contraindicated in pregnancy, at least the last trimester, for ACTUAL reasons, as opposed to poorly elucidated correlations that don't make sense mechanistically.

      February 24, 2014 at 17:33 | Report abuse |
    • cebundy@gmail.com

      My son and daughter are ADHD, but then so am I, and I was born well before acetaminophen. But I could see where it might affect it in some way.

      February 24, 2014 at 20:45 | Report abuse |
    • itsdone

      This is the type of fear-mongering and bad science that gives medicine a bad name. People in science are promoted and revered largely based on the amount of publications they can produce. This leads to garbage like this being published. Unfortunately, JAMA is one of the biggest culprits in the printing of bad science as long as it gets a "oh my God!" reaction and ends up on CNN and NYT. If you have the slightest bit of actual knowledge into research, you know right away that you cannot take a retrospective study design and prove cause-and-effect. This is ESPECIALLY true with things that are frequent (and overdiagnosed, such as ADHD) and something else most people do. Tylenol is recommended to all pregnant women in place of other more harmful pain relievers.

      i.e. If you asked every autistic patient or ADHD patients' parents if they used a cell phone while they were pregnant...BAM! There you go, cell phones cause ADHD. Or, did you drive a car while you were pregnant? YES?!! There you go, car driving causes ADHD!

      The ONLY way you can prove cause and effect is to have 2 blinded groups, one receives a placebo and one receives Tylenol. Then, the adjusted incidence of ADHD must be shown to be higher in the Tylenol group. I have been a reviewer for 2 major medical journals in my field. I would have trashed this article the minute it crossed my desk and it would have NEVER ended up in my journal! I guess it was just controversial enough to get published in JAMA despite the bad science!

      (If you can't tell, my pet peeve is this kind of grandstanding pathetic science that impedes progress, scares patients, and makes the medical community look bad! This is the same garbage that happened with vaccinations....well, before the investigators admitted it was all fake data and the study was a sham. Look at the damage it has done...kids die every day from preventable disease because you STILL can't overcome the inability to change peoples' minds!)

      February 25, 2014 at 08:22 | Report abuse |
    • rlj

      ITSDONE – the study does NOT claim cause-and-effect. Finding associations like this have value in that they point out what needs to be studied further, and serve as a caution. This is not exactly a study where you can give acetaminophen to pregnant women and compare with a control group. Don't misinterpret science and confuse people – there's enough mistrust already, and that is crippling progress here compared to other countries.

      February 25, 2014 at 09:17 | Report abuse |
    • Kiru

      They know a heck of a lot more about ADHD now than they did 20-30 years ago when I was growing up so it gets diagnosed more. Duh.

      February 25, 2014 at 09:49 | Report abuse |
  2. ben

    that isn't interesting, it is a random correlation. there is no reason to assume acetaminophen causes autism or adhd. it is entirely possible the correlation is related to pain and has nothing to do with acetaminophen. it is entirely possible the correlation is related to fever and has nothing to do with acetaminophen. statements like "interesting how the timeline correlates..." are inflammatory and serve no purpose, nor do they enhance the conversation.

    February 24, 2014 at 17:22 | Report abuse | Reply
    • Will S

      This isn't a random correlation. A random correlation shows no relationship. This is definitely a very strong correlation, especially given an n > 60,000 and p<0.001. That is a huge sample and incredibly strong correlation. Whether there is a causal relationship can be debated. This isn't pirates vs. temperature.

      February 24, 2014 at 17:36 | Report abuse |
    • Erin

      Will...the big N actually makes the fact the correlation is significant less impressive. Bigger samples mean correlations are more likely to be picked up by statistics. And the size of the correlation (it being a "big" correlation) is about the actual magnitude of the correlation. Like a correlation of .9 is a big correlation. A correlation of .1 is not that big. (Though what is considered "big" varies by field). The significance level (p<.001) doesn't say anything about size of the relationship, just how likely the relationship is to be real and not a relationship that showed up by chance and would not show up in another sample. I think that what Ben probably meant by random was the important point that cause and effect is not established here–that a third variable could account for that correlation and actually be the variable of interest.

      February 24, 2014 at 19:18 | Report abuse |
    • scientist

      It may be a significant correlation but that doesn't mean that there isn't something ELSE leading to mothers using acetominophen (like ben pointed out, pain or fever or maybe even a specific but common virus) that is the ACTUAL link to those ADHD like behaviors. This goes *especially* because acetominophen is largely considered the only safe painkiller to use during pregnancy, so if the mothers are experiencing pain or fever, they will most likely be taking acetominophen and probably nothing else.

      This study by itself is worthless as it pertains to the effect of maternal use of acetominophen on children later developing ADHD – but a good base for other studies.

      February 24, 2014 at 22:00 | Report abuse |
    • scientist

      There could also be some mystery third factor that correlates with the lifestyle that would lead a mother to use acetominophen vs. not use it. Much like those junk studies that say that people who eat specific fruits tend to be healthier – the usual cause is that people who eat fruits in the first place generally have the money and time to eat a healthier diet than those who don't eat any fruits and vegetables.

      February 24, 2014 at 22:05 | Report abuse |
    • Ned Needlemier

      Your observations are correct. The correlation could also have been associated almost anything that is used by a large percentage of the population from foods that used pesticides, to eating meat. The observation of no direct cause, blows the correlation out of the water. It is like correlating the ADHD effect to the consumption of chocolate, because most people that have effected children also had chocolate, or caffine, or red wine. Without a controlled study, no conclusion can be drawn, but they did start some more fear mongering. I am sure that McNeil has done a study of this, their study probably correlates this finding of now cause.

      February 24, 2014 at 22:17 | Report abuse |
    • Judas Priest

      Replying to the thread here to say 2 things, first, thank you, it's good to see civil, intelligent discussion on these blogs, and second, it's not hard proof of a correlation but it is a very strong indicator and further studies really need to be done to determine if it is the acetomenaphen, what the mechanism is if that is the case, and if there are other factors involved.

      February 24, 2014 at 23:24 | Report abuse |
    • Mat

      Actually, Erin above is wrong. A large sample size means that a meaningless correlation is significantly less likely to occur. She's got her understanding of a pretty basic stats topic completely backwards. If you have 6 people, and one of them fits the hypothesis, you've got a correlation, however, if you've n >60K, the odds of such a non-meaningful correlation is extremely unlikely. I'm nut sure she has any idea what she's talking about.

      February 25, 2014 at 00:39 | Report abuse |
    • Jim

      Aseptic techniques were established based on correlation.

      February 25, 2014 at 02:33 | Report abuse |
    • rlj

      The study does NOT claim cause and effect.

      February 25, 2014 at 09:29 | Report abuse |
    • SS

      Interesting how all of a sudden you are a medical scientist who does countless research studies. Please direct us all to the links of your research.

      The article clearly states that more needs to be done, your statement of "there is no reason to assume acetaminophen causes autism or adhd". Don't go making claims when you have 0 factual evidence to back it up. You are simply stating your own opinion, which is fine, but you should also be leading your sentences with "in my opinion" since this is in fact your opinion and you have 0 evidence to prove your claims.

      February 25, 2014 at 13:28 | Report abuse |
  3. Matt

    "You know why we're crack babies? Because we're born in the 80's, the ADHDs crazy"

    February 24, 2014 at 17:23 | Report abuse | Reply
  4. Kirstyloo

    People take Acetaminophen for fever and illness. Both of these have been linked to increased problems during pregnancy. The cause might not be with drug itself. Instead, it could be linked to infection

    February 24, 2014 at 17:30 | Report abuse | Reply
    • scientist

      Exactly. It isn't surprising to think that inflammation could cause fetal damage (or even a specific but common virus – type 1 diabetes for example has a genetic component but is most often triggered by a specific kind of common stomach flu virus).

      February 24, 2014 at 22:07 | Report abuse |
    • Teri

      I would come closer to thinking it was biological in nature than related to a drug, too. But, not convinced it is something that happens during the pregnancy. I was on Wellbutrin when I got pregnant, removed cold turkey at my first OB visit, and then again for my 3rd trimester. The kid is fine. I had horrid morning sickness to the point where I weighed less at the end of my first trimester than when I got pregnant. I was on bed rest for 2 weeks at 2 months due to heavy bleeding. I had the flu and pneumonia and 3 kidney infections while pregnant (2nd and 3rd trimester). I was on Tylenol, Sudafed, Benadryl, and antibiotics. My daughter was born a month early (induced) due to complications and early contractions which led to heart rate problems on her end. So there were many chances for things to go wrong, yet we lucked out with a perfectly happy and healthy baby. I just find it difficult to believe some of these studies and wonder if it isn't something that happens after pregnancy and childbirth that causes it. Both ADHD and Autism.

      February 24, 2014 at 22:35 | Report abuse |
  5. Eric

    Or it could be simply that some families subscribe more to our pill culture than others. Note that the article is about increased risk for "use of" ADHD medications, not increased risk of ADHD per se. Not saying that there aren't pregnant women who have legitimate chronic pain, but maybe where there's smoke, there's fire.

    February 24, 2014 at 17:39 | Report abuse | Reply
    • Will S

      The study took place in Denmark. They don't have the same sort of "pill culture" that the U.S. does.

      February 24, 2014 at 17:55 | Report abuse |
    • colorserenity

      It is true Denmark doesn't have the pill culture. That is huge. We have been so brainwashed to think America's dependence on drugs is progressive that we miss the obvious. We don't need all these pills to survive. People live quite acceptable lives without the cult like belief in pill popping. What this ought to do is inspire studies about why other countries differ from us. How they differ from us and if there are advantages in changing our drug culture. Of course, that would lower profits to otc and pharmaceutical suppliers. And we can't have that. So we let them slowly poison us with the drug drama we have become too used to.

      February 24, 2014 at 19:28 | Report abuse |
  6. mrsmontanez

    Reblogged this on Bipolar Mom, Authoress.

    February 24, 2014 at 18:22 | Report abuse | Reply
  7. tony

    Don't take CIPRO ever. The pain from nerve damage side effect is far more prevalent than claimed, because so many doctors are swayed by CIPRO positive advertising, they misdiagnose it as caused by other things.

    February 24, 2014 at 18:32 | Report abuse | Reply
    • scientist

      Or you just were unlucky enough to experience the rare side effect and therefore claim anecdotally that it happens more than they claim...

      February 24, 2014 at 22:08 | Report abuse |
    • Teri

      I ended up with drug-induced Lupus from taking Levaquin, which is in the same family as Cipro. I refuse to take either now.

      February 24, 2014 at 22:36 | Report abuse |
  8. roginac

    I was diagnosed with pregnancy induced migraines at 14 weeks. I went into the hospital and had an MRI due to the way the migraine presented. The MRI showed an abnormality. I then underwent a spinal tap to make sure it was not an aneurysm.It was determined that I had swelling in my brain. The Neurologist told me this was common with intense migraines, and to take tylenol migraine. He also said as long as I did not go over the daily limit that I could take several at once if needed. This Migraine lasted 6 weeks. It was only bearable due to the Tylenol. At the time I was concerned over taking any medication, but studies supported his recommendation. I am not a pill popping person, and avoid them whenever I can.My son is now a healthy, happy 4 year old with no indication of any issues.

    February 24, 2014 at 18:37 | Report abuse | Reply
    • Don

      You got lucky. You should never have had the spinal tap after the MRI showed "swelling in your brain." Your brain could have herniated down into your foramen magnum once they popped that needle into your spinal canal!

      February 24, 2014 at 18:44 | Report abuse |
  9. Fish

    Well that's just fine Wall Street, my daughter thinks she's a man with ADHD, my son is a malcontent and now we get the news Tylenol could be the culprit??? Where the hell were these whiz kids was this stuff was approved to enter the marketplace??? I remember distinctly when doctors are saying no aspirin take Tylenol!!! Now after my grandmother, a Tylenol freak died from liver cancer, my mother ,another T freak has liver issues, my kids are both ADHD and irresponsible as hell we get this newsbreak. What took so long??? Don't tell me Wall Street again???

    February 24, 2014 at 19:01 | Report abuse | Reply
    • scientist

      Because a link like this takes a lot of time to find? Because the cause might not actually be acetominophen (could be fever/inflammation/etc. which are often treated with acetominophen)? Because any theoretical fetal damage that could cause ADHD is invisible to researchers as the science stands now?

      February 24, 2014 at 22:10 | Report abuse |
    • Chicka

      Tylenol and liver damage is well known. As for this study, one study does not absolute truth make. Until further study is done, Tylenol is still the safest medicine for pregnant women to take; no medicine at all is even better, though.

      February 24, 2014 at 22:37 | Report abuse |
    • Mom of ADHD child

      There has been some research linking ADHD to mothers having strep infections while pregnant, or the child having strep infections when very young. 70 years ago if the family had strep (scarlet fever) the house was quarantined. After the use of antibiotics came along, nobody thinks twice about being around babies when they have a sore throat. Moms keep your babies away from the public until they are 3 months old, it might save you a lot of trouble later on.

      I expect the acetaminophen use correlation is the disease that caused the pain in the first place. Not the acetominophen itself.

      February 24, 2014 at 23:03 | Report abuse |
  10. Heidi Robinson

    Why don't these doctors and drug companies find preventions that so many people in other parts of the world already know about? Oh, that's right. ..... it's all about money and power. Trillions of dollars that the drug companies are making off of people getting sick and countless other diseases.... that kind of money buys a lot of power..... and corruption. It doesn't have to be that way. Look into solutions and even side effects that many oriental countries have known about and practiced for thousands of years! !!!

    February 24, 2014 at 19:26 | Report abuse | Reply
  11. Fish

    I have no doubt that when we are all dead and gone, Tylenol will be a significant factor in dementia and Alzheimer's We only can't know now because of the money involved!!!! Big Pharma, Big Oil have killed more people in America than wars!!!

    February 24, 2014 at 19:34 | Report abuse | Reply
    • scientist

      Big Pharma...everybody's favorite strawman. Try actually living by your anti-drug policy and see how that goes for you.

      February 24, 2014 at 22:11 | Report abuse |
    • FamilyDoc2

      @scientist: When you have a multi-billion dollar industry that has arguably the most effective lobbying in the world, it is ridiculous to claim that Big Pharma is everyone's favorite strawman. Many things happen in the drug industry and its regulation that are opposed to what is best for the public: the extension of drug patents ad nauseum, adverse patient data from phase 3 studies is kept hidden by the FDA and Pharma, and drugs that clearly should be removed from the market are allowed to remain (such as rosiglitazone). It is difficult for the general public to be aware of the extent of influence that BIg Pharma has on the FDA board, on the boards of prestigious medical publications, in Congress and thus in our lives. By the way, scientist, which pharmaceutical company signs your paycheck?

      February 25, 2014 at 06:43 | Report abuse |
  12. Ctrygrl

    acetaminophen is a poison pure and simple. It destroys the liver and yet hospitals dispense he stuff at the drop of a hat. Yes I realize when bleeding is a danger you cannot take aspirin or any other NSAID but when this is not an issue aspirin should be the go to NOT Tylenol. I do not use it the stuff is dangerous very dangerous.

    February 24, 2014 at 19:59 | Report abuse | Reply
    • Jag07

      Everything is dangerous when you take too much of it. Do you know how much acetaminophen you have to take in a day to cause a problem? Do you understand that other than acetaminophen and NSAIDs that the only drugs left over for pain relief are opioids? You know that class of drugs that are all over the news right now as being the most terrible thing that doctors can prescribe because it is making America into a land of junkies and addicts? Which when used by those actually in pain does not cause addiction. Bad doctors and thieves give medicine a bad name when it comes to pain relief. It is one of the most difficult things to treat.

      And to the others that think big pharma just makes you spend money for no reason, look up an article here on CNN about the conditions that go on in the foreign pharma manufacturing sites that make your oh so precious generic medications. You would be appalled at the conditions that your drugs are manufactured in over there. The corruptions and general lack of concern. Plus if pharma was that good at lobbying then obamacare would not have happened. Single payer models are bad for business. Meaning they will be nice to you because it drives down prices but it takes money out of the companies that do the research for those miracle drugs that people want.

      February 27, 2014 at 09:50 | Report abuse |
  13. michaellocher

    I'm skeptical, as is wise when any such report emerges, no matter how credible on its face.

    That said, I will NOT forward this one to my wife. Like many American women, she took her share of Tylenol during her pregnancy with our daughter. We've got enough to worry about. Parenting, like pregnancy, is stressful enough as is. I'll leave the currently expecting, or soon to be expecting, to wrestle with this one.

    If any one shares this with my wife, I'll kill them.

    February 24, 2014 at 20:23 | Report abuse | Reply
  14. jane

    "There are nonpharmacological ways to deal with pain,” says the MALE doctor who will never experience the burden of pregnancy and the arrogance of the medical profession which treats pregnant women as commodities while treating the pain of men as world ending. Maybe we should just go back in time before there was modern medicine. Out law doctors and there would be no need for this junk science (which is based upon maternal self reporting and not actual monitoring) and babies and mothers would all be perfect...oh wait they died in droves. Arrogant male doctor!

    February 24, 2014 at 23:51 | Report abuse | Reply
    • wuzzup

      Jane, have you run across a diet board, lately. 80% women participate. They're like pelicans on a school of anchovies! They're down anything (pill-wise) at the drop of a hat. The unregulated field of supplements and diet aids? These brain surgeons will ingest those, no questions asked. Drugs have become "Fantasy in a Bottle". Young women, today, are downright reckless when it comes to pills.

      February 26, 2014 at 00:54 | Report abuse |
  15. Jim

    ADHD is a scam that made psych doctors and pharma money. It's listing and symptoms in the DSM have been nothing but controversial and political (within the medical community). The symptoms are ssubjective and reflective of all childhood behavior.

    February 25, 2014 at 02:32 | Report abuse | Reply
    • bloorain

      a a parent of a child with adhd i can assure you he's not just displaying normal behaviors. if you see him and a "normal" kid together there is a big difference. i am going to assume you either don't have kids or have "normal" kids and see adhd and autistic children as naughty and needing proper disipline.

      February 25, 2014 at 02:48 | Report abuse |
    • janer52

      Agreed. A scam that lets people put children into compartments. don't deal with their behavior, just give 'em a pill. it's disgusting.

      February 25, 2014 at 08:29 | Report abuse |
    • Kiru

      You don't know what you are talking about. Not all children act like ADHD children. If you give non-ADHD children ADHD medication it doesn't make them better it makes them hyper. It is not a scam, it is not bad parenting. People who have not had to deal with it personally do not understand it , and yes, in public to someone who doesn't understand it, it looks like bad behavior. ADHD means that NO MATTER HOW GOOD A PARENT YOU ARE there are going to be behavioral problems. To keep them under control you HAVE to use medication, especially at younger ages. As they get older symptoms may improve and/or they can learn some behavioral modification but chances are, they will always need some medication for certain types of situations and environments.

      February 25, 2014 at 09:54 | Report abuse |
  16. Helene

    My son, who is now 21, has ADHD and was diagnosed by age 3. My pregnancy with him was very rough, due to a car accident I was in, 9 months before he was conceived. I have permanent back damage from the accident, and was in serious escalating pain during the pregnancy. While I probably needed morphine, all I was allowed to take, was Tylenol. I took it around the clock for weeks, till it became clear that it did nothing for the pain I was experiencing. Basically eating dirt would have had the same effect. So I stopped taking it and survived in misery, till the birth. Since Tylenol was the only drug besides the prenatal vitamins that I was taking, this study actually makes sense to me.

    February 25, 2014 at 10:24 | Report abuse | Reply
  17. debbybruck

    Reblogged this on Debby's Blog and commented:
    Acetaminophen, brand name Tylenol, the common pain and fever reducing drug, causes liver and kidney damage. New studies indicate Tylenol causes fetal damage (ADHD / HKD) when taken by pregnant mothers. What does everyone have to say about this 'surprising' news? Could a 'hormone disruptor' be safe to take during pregnancy? http://www.homeopathyworldcommunity.com/forum/topics/tylenol-drug-recalls-johnson

    February 25, 2014 at 11:00 | Report abuse | Reply
  18. Missy

    Does it really take a correlation or cause/effect relationship to be established by a study or experiment for women to know that we shouldn't be taking any medications that are not absolutely necessary during pregnancy? Is it really surprising to anyone that the foods or meds we ingest during pregnancy affect fetal development? SMH

    February 25, 2014 at 11:43 | Report abuse | Reply
  19. mother of adhd son

    I do not believe Tylenol has any thing to do with ADHD. I believe it is genetic....My husband, his brother as well as my son and 2 nephews all are ADHD. I had a normal healthy pregnancy other than morning sickness and afternoon fatigue and some heart burn. All of the information I have read on ADHD has never lead me to think it was caused by any medication and I honestly don't remember taking any Tylenol.

    February 25, 2014 at 14:31 | Report abuse | Reply
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  22. autismepi

    Do not be so quick to dismiss these findings and please proceed with caution. This is the SECOND well controlled, prospective cohort study to find an association between prenatal acetaminophen use and adverse neurodevelopment. There is biologic plausibility and a number of animal studies that also support this association.

    http://www.reuters.com/article/2013/11/22/us-tylenol-pregnancy-idUSBRE9AL15L20131122

    http://www.ncbi.nlm.nih.gov/pubmed/24163279

    Animal studies:

    http://www.forbes.com/sites/eamonnfingleton/2014/01/15/swedish-researchers-raise-safety-concerns-about-j-js-tylenol/

    http://www.ncbi.nlm.nih.gov/pubmed/24361869

    http:/www.ncbi.nlm.nih.gov/pubmed/24316461
    http:/www.ncbi.nlm.nih.gov/pubmed/22512254

    http://www.ncbi.nlm.nih.gov/pubmed/21170329

    Ecologic studies with discussion of biologic plausibility:

    http://www.ehjournal.net/content/pdf/1476-069X-12-41.pdf

    http://greatplainslaboratory.com/home/eng/Acetaminophen.asp

    February 26, 2014 at 15:38 | Report abuse | Reply
  23. Dadoc Lee

    Another example of sloppy thinking promulgated by the pharmaceutical industry. ADHD is treated as a biologic illness (the Rx for which is methamphetamine & similars) with no psychological ramifications. The truth is that MOTHERS who take tylenol during pregnancy have more kids with ADHD. Could be the drug's effect, but might have to do with the psychological mindset of moms who have headaches/take meds during pregnancy, and the effect their mindset has on the evolution of ADHD (kids generally get anxious about their mothers' problems). Drug companies don't want to promote psychological thinking as it might cut into the enormous profitability of starting kids on meth and then being able to hide the most disastrous results in prisons and mental hospitals.

    February 26, 2014 at 17:18 | Report abuse | Reply
  24. Nellie

    Link to this story says (ASPRIN) or is it ASPIRIN linked to ADHD. Subject switched to ACETAMINOPHEN being the link. Which is it Aspirin or Acetaminophen ? Don't think they are the same !

    February 27, 2014 at 09:26 | Report abuse | Reply
  25. RxJiMac

    As a pharmacist, it is my most positive advice to not take ANYTHING when pregnant unless absolutely necesssary or prescribed by the physician. Simple pain or "headaches" can be tolerated or ignored and will diminish in a relatively short time. ANYTHING you take is shared with the fetus and in the early formative months when the child is the size of your thumb and cellular division is rampant, growing lungs, hearts, livers and backbone and every other structure, it is foolish to introduce foreign chemicals into the mix. Take your prenatal vitamins, and nothing else. Ingest the best nutrition you can to grow your baby into the wonderful miricale you will birth. Certainly there are times when the health of the mother must be weighed agaist the possible detrement to the fetus, but unless there is is no other choice, TAKE NOTHING!!! RxJiMac/Atlanta

    February 27, 2014 at 10:10 | Report abuse | Reply
  26. Tati

    As a perent of a child with diagnosed SPD and possible Autism, this is ridiculous. At 8 months of pregnancy I was hospitalized with fever of 104 and the only thing i could take to keep my unborn child from overheating inside me with my fever. I have read that the SPD could have been due to high fever durning pregnancy, and now i red it could have been to the Tyleno during pregnancy. So i guess what this article is basically saying that i should have picked febrile seizures and spontaneous premature labor over taking Tyleno which saved our lives. This is insane. Just because its on the Internet it doesnt mean it came from Heaven, people.

    February 27, 2014 at 11:31 | Report abuse | Reply
  27. Chuck T.

    The headline in AOL says... Aspirin linked to ADHD... No where in the article does it mention aspirin...

    February 27, 2014 at 11:35 | Report abuse | Reply
    • Marlene G

      Thank you, Chuck. Aspirin and acetaminophen are NOT the same thing.

      February 27, 2014 at 12:30 | Report abuse |
  28. superhumanradio

    choose whats best and before taking any medicines think wisely.but you should try to trust your doctor if its necesssary or prescribed by the physician. thanks for this post it gave us nice information.

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    February 27, 2014 at 21:48 | Report abuse | Reply
  29. Eye Health Care

    Nice blog as it discuss about various unnatural diseases present in human body. It suggests us how to cure them.

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    February 28, 2014 at 04:55 | Report abuse | Reply
  30. alice

    UGH I took Tylenol frequently when I was pregnant and my daughter has ADHD. I feel so bad.

    March 3, 2014 at 08:19 | Report abuse | Reply
  31. shikha

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    March 6, 2014 at 23:16 | Report abuse | Reply
  32. Casey Deborah

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    March 17, 2014 at 17:59 | Report abuse | Reply
  33. Thomas L.

    The most interesting thing I noticed about this article was the fact that some of these women were taking this over the counter drug for 20 weeks and late into pregnancy. I think it is common sense that this can possibly cause bad side effects of various kinds. It also makes me wonder how this drug effects attention levels in just regular adults taking it as well.

    August 12, 2014 at 15:51 | Report abuse | Reply

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Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.