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Therapy shows promise for halting Alzheimer's brain decline
July 17th, 2012
03:38 PM ET

Therapy shows promise for halting Alzheimer's brain decline

Finding drugs that can halt or reverse the effects of Alzheimer’s disease is one of the holy grails in pharmaceutical research.

While the already-approved Aricept and Namenda medications have shown promise for temporarily easing symptoms, what’s desperately needed are treatments that will reverse or prevent the brain decline produced by Alzheimer’s.

Researchers are seeing promising results of the first long-term clinical trial that measured stabilization of Alzheimer’s symptoms, including thinking, memory, daily functioning and mood. The early stage results were presented at the Alzheimer’s Association International Conference in Vancouver, British Columbia, this week.

The treatment, Gammagard by Baxter, is an intravenous immune therapy that is already approved for treating other immune disorders and infections.

The small study of Gammagard included 16 subjects with mild to moderate Alzheimer’s disease who were in the first part of the trial and agreed to continue the study for three years.   What’s exciting about the results of this trial is that doctors say  four of the patients who continued treatment at the highest dosage showed a stop in the worsening of symptoms, making this small study the first to report symptom stabilization without decline over that longer time span.  Larger studies will begin later this year.

In addition to the Gammagard findings, researchers reported updates on three new pre-symptomatic Alzheimer’s disease studies that are scheduled to begin in the near future. Because recent clinical trials have produced disappointing results, there’s a belief among many Alzheimer’s researchers that the key to cracking the code for treatment success is by testing therapies on people who are predisposed to Alzheimer’s disease, yet are not symptomatic.

Several trials in the future will focus on that, including trials in a rare population living near Medellin Colombia that is prone to genetically-caused, early onset Alzheimers.

“Improving detection technologies and updated diagnostic guidelines are enabling the detection of early changes in the brain and subtle cognitive deficits that are consistent with what is known as pre-symptomatic Alzheimer’s,” according to William Thies, the Alzheimer’s Association chief medical and scientific officer.

Thies says people in this group are the ideal subjects for prevention trials, which might delay or slow the progression of their disease.

Approximately 5.4 million Americans live with Alzheimer’s disease and it’s the 6th leading cause of death in the U.S. Alzheimer’s is the most common type of dementia, a term used to describe memory and intellectual loss severe enough to interfere with daily activities. It’s caused when deposits of proteins form in the brain and preventing it from properly functioning.


soundoff (58 Responses)
  1. glioblastomarunner

    Dream on. Nothing is going to stop my wifes decline, nothing short of the brain stopping it's work altogether, which is unfortunatly all someone horrified by watching it, can hope for.

    July 17, 2012 at 16:53 | Report abuse | Reply
    • mitomomma

      in reply to mike..vacinations require routine booster shots to be effective. Antibiotics, generally aren't given over the course of one's life. Nothing funny about that, it's actually pretty simple.

      July 18, 2012 at 07:32 | Report abuse |
    • sam stone

      my condolences about your wife's condition

      July 18, 2012 at 10:45 | Report abuse |
    • lindaluttrell

      I lost my mother to brain cancer years ago. So sorry for what your wife and you are going through. My thoughts are with you.

      July 18, 2012 at 18:35 | Report abuse |
    • msadr

      I'm so sorry. Hang on to the coherent moments. They are so valuable for both of you.

      July 18, 2012 at 21:35 | Report abuse |
    • MomofTeens

      I too lost my mom to metasticized brain cancer (orig. breast cancer). It was fairly rapid compared to Alzheimer's but still awful. The six months of her decline tore my heart to pieces, I give great credit to the loved ones of Alzheimer's patients for the years of pain they endure. God Bless.

      July 19, 2012 at 14:48 | Report abuse |
    • MIchael

      I don't know where your wife is, but mine is in mid-stage Alzheimer's. She's only 51, and has been showing symptoms which have become progressively worse over the past 5-6 years. My worry is that she's going to be too far gone for this to help by the time it becomes available, assuming it pans out. It's a rough road, no doubt, and you have my sympathy, as does everyone dealing with this horrible disease. I hope someday, we'll find a cure, but in the meantime, trials like this can give us something to look forward to. Best of luck.

      July 20, 2012 at 06:39 | Report abuse |
    • Fred

      I am very sorry for your wife..Really am. My son has Autism and I know your feeling. Do some research in Herbs specially pomegranate and w-3 with Bio-oxidative therapy(H2O2 therapy) with high dose Cocconut oil with Hyperbauric O2 therapy also LED light therapy (cold laser). It will help tremendously. Good Luck

      August 2, 2012 at 10:57 | Report abuse |
  2. Primal 4 Life

    If this medication does not need to be taken for life, it will never be released.

    July 17, 2012 at 17:45 | Report abuse | Reply
    • Mike

      That's funny. Can you please explain why vaccinations and antibiotics are released? (This should be good)

      July 17, 2012 at 20:54 | Report abuse |
    • Annie

      Yep, if Big Pharma doesn't make the money, it won't be on the market. Money, I mean selling only medications what you should take for life, that's how the investment works for them.

      July 18, 2012 at 14:27 | Report abuse |
    • Patrick

      Annie - ridiculous. There are all kind of medications that are not taken for life. Antibiotics. Chemotherapy. Chemotherapy is actually a pretty good comparison - as to many cancers, it increases substantially the likelihood of survival, so people are willing to pay quite a bit for it, and thus, drug companies can make a good profit even though the drug is taken for a relatively short period of time. The same would be true for an alzheimers drugs. Given the number of people affected and the lack of any current effective treatments, even a drug taken over a short period of time could be hugely profitable (not to mention well received by those with alzheimers and those who love them)

      July 19, 2012 at 14:09 | Report abuse |
    • Fernando

      One drug, Lipitor, brings in more money than the total for vaccines in this country. It often takes government funding and incentives to get new antibiotics and vaccines manufactured. Big Pharma is much more motivated to develop a new drug that will give you a BigBona® than save you from a big infection.

      July 21, 2012 at 01:42 | Report abuse |
  3. Vincent Demonbreun

    Organic coconut oil does the same thing

    July 17, 2012 at 18:11 | Report abuse | Reply
    • jj

      Yes, organic coconut oil is fantastic!

      July 21, 2012 at 14:29 | Report abuse |
    • kendray4

      where is the evidence that organic coconut oil helps treat Alzheimer's disease. Please can you provide a reference. This report about Gammagard is great news, hopefully the research will be repeated and the drug made available in the near future. Prolonged stress can lead to alzheimers disease, it is important to look after your brain and treat stress and anxiety-for more http://treatanxiety.co – it is important to avoid prolonged stress, eat a healthy diet and exercise regularly

      August 6, 2012 at 17:57 | Report abuse |
  4. PharmD

    Gammagard(TM), as well as any intravenous immunoglobulin (IVIG) for that matter, would be an incredibly expensive treatment for Alzheimer's. One of the study authors estimated $2,000-$5,000 every 2 weeks. Also, since it requires intravenous access, there is a risk of infection & sepsis.

    IVIG is a peculiar substance. It's actually derived from the plasma of ~10,000 donors: the plasma is pooled together, followed by extraction of immunoglobulin G, purification to remove pathogens, and then bottling for use. By pooling all of these donors' antibodies together, the patient will hopefully receive antibodies that will neutralize the antigen responsible for the patient's condition. I would be hesitant to use this for a non-life-threatening condition, because I believe there is still a non-zero risk of contracting a pathogenic disease.

    July 17, 2012 at 18:56 | Report abuse | Reply
    • SixDegrees

      Alzheimer's is fatal. Is that "life threatening" enough for you?

      July 18, 2012 at 03:39 | Report abuse |
    • Eric

      What a specious argument. There is a non-zero risk of slipping in the shower & getting a concussion. There is a non-zero risk of getting into an accident on the way to work.

      Any medical intervention carries risk; are you so obtuse as to think that there is never a risk/benefit ratio that is always at play?

      July 18, 2012 at 12:25 | Report abuse |
    • msadr

      It IS life-threatening. And where there's a will, there's a way. More appropriately, where there's a consumer, there's a product. The pharmaceutical companies will find a way to make it more convenient and available to the average insured patient one way or another.

      July 18, 2012 at 21:37 | Report abuse |
    • PharmD

      I did try to emphasize the risk/benefit ratio. But I also mentioned the cost as well, which should be factored into its utilization. It is also a resource limited by the number of eligible plasma donors.

      Moreover, this study only demonstrates that it halts the progression, and doesn't reverse the disease. By your logic, everyone at risk for Alzheimer's should be put on IVIG for the remainder of their life. Over a year, a course of therapy would be 832 grams (for an 80 kg person). It takes 4 donations to make only 12 grams; this would come out to 277 donations to treat one person for a year. Given that there are 5.4 million people with Alzheimer's, it would take ~1.5 billion donations/year to cover all current Alzheimer's patients! Because people can only donate plasma twice a week in the US, the number of donors needed would be at least ~14.4 million if they never skipped a donation. It would be very doubtful we could reach this target, since potential donors might be excluded due to certain criteria. You should also keep in mind that the number of donors needed may increase rapidly, owing to the projection that Alzheimer's prevalence may increase rapidly as the baby boomers age.

      Even right now, there is a shortage of Gammagard; fortunately, other IVIG products are available. I suppose the plasma companies could try to entice more healthy people to donate by raising the payments for donating plasma, but they would just pass on the added cost to the consumer.

      Also, would you want to cause a shortage for those who absolutely need IVIG to survive, such as the reader who has hypogammaglobulinenemia? There is no alternative agent for patients like this.

      Instead of using IVIG for Alzheimer's, treating Alzheimer's will be much more practical when a monoclonal Anti-Alzheimer's antibody is successfully identified, synthesized, and confirmed in clinical trials. Then, there would be no limit due to the need for plasma donors and there would be no risk of pathogens, since it could be synthesized in a lab.

      July 18, 2012 at 23:00 | Report abuse |
    • Jo Ann

      Expensive, yes, but if it prevents the need for expensive nursing home care, it may ultimately be a bargain.

      July 19, 2012 at 18:26 | Report abuse |
    • Rafsan

      We were at the SLC show, and were so impressed with these drnecas. While we thought a little time between dances would have been nice in order for them to at least take a brief bow, it was otherwise a stunning show. Melanie's solo was as gorgeous as I remembered it. The dancer who captivated us the most was Jess completely unexpected. We knew they were all good drnecas, but he just seemed to never let up. Wonderful technique, but also a passion for what he was doing. We were tickled with how he would often yell during the group numbers, almost like a football player would do to pump others up. Ricky was another who danced with such conviction. Loved it and would go again

      August 2, 2012 at 11:56 | Report abuse |
  5. Margi

    Where would the money come from?

    July 17, 2012 at 20:58 | Report abuse | Reply
    • msadr

      Taxpayers of course. Haven't you read about Obamacare?

      July 18, 2012 at 21:38 | Report abuse |
    • Lisa

      I went to the Rosemont show last night. Very disappointed to have it at the Allstate Arena where the seats are so small. There are so many beettr venues to choose in this area. I have been to the tour every single year since the start with the season 2 cast. The show was jam-packed with dancing, but it felt horribly rushed. It felt like they were just trying to get it over with as fast as possible. It was also a shame to hear that Sasha and Missy were not able to perform and many of the numbers seemed bare without them. The whole show felt like it was missing a lot of content, which I predict is because Sasha's dances most likely just got cut. It was even worse to see them bring out the set for the breakfast table dance and then just take it away. Major tease. If they had to cut her dances out, why not replace them with some other ones? The 7:00 show started 15 minutes late, had a 30 minute intermission, and finished before 9:30. I defeinitely felt like we missed out on performances that were cut because of the injured dancers. The show also felt like it was lacking in energy. I missed the dramatic beginnings where the contestants would all come out with a high energy dance, say hello to the crowd and introduce themselves. Because the contestants did not speak, it was really hard to connect with the show. In all of the years past, I left feeling like I was at a great show that I would love to see again, but this year, I left with negative feelings.

      August 1, 2012 at 18:40 | Report abuse |
  6. Joyce

    I've taken IVIG gammaglobulin for 28 years due to hypogammaglobulinenemia with subclass deficiency. I'm wondering if takng IVIIGfor all of these years will prevent me from getting dementia or Alzheimer's. I do take another brand than Gammagard (Gammunex). My Mother had dementia during the last years of her life.

    July 17, 2012 at 23:17 | Report abuse | Reply
    • Desert resident

      Interesting post. Perhaps you should write to the authors of the study. You may be part of a group which already has years of history in a similar or related area of the study.

      July 18, 2012 at 01:16 | Report abuse |
    • msadr

      Wow! You should be involved in the research for sure.

      July 18, 2012 at 21:39 | Report abuse |
  7. PharmD

    Margi, I think the money would be out of the patient's own pocket, until the insurance companies recognize IVIG as a legitimate therapy for Alzheimer's worth paying for. At the very least, this study does support the current approach against Alzheimer's, which is to develop an anti-Alzheimer's antibody (e.g. crenezumab & solanezumab). Unfortunately, some drug trials have failed (Ponezumab), and some believe it's because the antibodies were aiming at the wrong target (amyloid beta protein).

    Joyce, it does seem likely that the Gamunex may have the same effects as the Gammagard in this study. However, it would be hard to make a definitive statement, because each brand may obtain plasma from different donor populations, and there may be differences in the extraction/purification process.

    July 18, 2012 at 02:12 | Report abuse | Reply
    • PCP Doc

      I'm always amused when people type things lke, "until the insurance companies recognize" or cover this. People don't realize that the 'insurance companies" are just spending YOUR money. I work with another physician every day that moans about how insurance companies won't cover all the expensive drugs he writes for, what he and most people don't realize is that you can't complain about insurance companies not paying for things AND insurance premiums going up in the same argument. They're spending YOUR MONEY.

      July 18, 2012 at 09:43 | Report abuse |
    • msadr

      PCP Doc I think you just went over the heads of every Democrat on CNN.

      July 18, 2012 at 21:43 | Report abuse |
    • Joyce

      I'm wondering if you can help me get in touch with the right people from the IVIG study. I'm Joyce, the Hypo IGG patient who you made a response on this CNN page. I would like to be a part of their study, and, know of several other patients like me. My immunologist (now retired) was Dr. Nabih I. Abdou who was very influential in immunne disorders worldwide. Thank you very much for your time and trouble. Joyce

      July 18, 2012 at 22:18 | Report abuse |
    • PharmD

      Hi Joyce, it looks like the presenter of the research is Norman Richard Relkin, M.D., Ph.D. According to his website (http://www.weillcornell.org/relkin/), here is his contact info:

      Phone (212) 746-2441
      Fax (212) 746-5584

      428 East 72nd Street
      Suite 500
      New York, NY 10021

      Best wishes to you, and hope you can contribute to the research!

      July 18, 2012 at 23:14 | Report abuse |
  8. Phillip Blkaskovich

    Until we know whether the amyloid plaque that encapsulates the beta tau protein is the cause of dementia or merely the result of the body's immune system attempting to isolate the protein irritant, much like an oyster does with a grain of sand, we cannot conquer this horrible disease that slowly kills, not just the patient but those who love the patient as well. If we spent 10% of our current military budget on finding a cure for a diseases such as this one, we would reap the benefits of not only sparing the victims & their families but the cost savings to the medical insurance industry would be astronomical. Drugs such as Aricept & Namenda only slow the progress initially but heighten the anxiety of those taking them as the disease progresses and prolongs their agony as well as their families.

    July 18, 2012 at 08:47 | Report abuse | Reply
    • msadr

      I agree that so much needs to be done to understand the disease. But there's a lot to be said for the "trial-and-error", "see-if-this-works" approach to treatment. Going on an educated hunch and giving something a try can have very positive results, even if they aren't totally understood.

      July 18, 2012 at 21:41 | Report abuse |
  9. Mike

    It amazes me how "natural" deterioration gets classified as a disease. Ronald Reagan was 93 when he died from supposed Alzheimers disease. We should all be so lucky, he had an amazing life...

    July 18, 2012 at 23:45 | Report abuse | Reply
    • Sherry

      There is nothing 'natural' about Alzheimer's or dementia. I've watched in my own family. Body parts wear down with age. It's a fact. But especially with early onset dementia, there's nothing 'natural' about it. You have to have lived with it, perhaps, to really 'get' that.

      July 19, 2012 at 11:49 | Report abuse |
    • AlzProfessional

      What about people who are diagnosed with Alheimer's disease at age 40. Do you think that's normal. There is nothing normal about watching a person lose everything that makes them them. Your comment is insensitive. You're luck he lived to be 93. Others aren't so fortunate

      July 19, 2012 at 12:26 | Report abuse |
    • Tony

      How would you feel getting a three am call from your mother across the country because she thinks she's at your house? That's not a full life at all, normismit normal ageing.

      July 19, 2012 at 18:59 | Report abuse |
  10. mom4444

    No one commented on the organic coconut oil. Any thoughts?

    July 19, 2012 at 07:57 | Report abuse | Reply
    • weeble

      Have had my mom on that for 3 mos. She has moderate dementia. Noticed no difference whatsoever. The only thing that has made a difference is weekly B12 shots. Her doc said 'go for it' when I showed him the study. B12, being water soluble, is no worry to take that regularly. Research and see. Google B12 shots, study, dementia.

      July 19, 2012 at 21:57 | Report abuse |
    • Yes1fan

      My wife has severe Essential Tremor, mostly controlled with a DBS.
      Her use of Caprylic Acid, made from Cocoanut Oil, works quite well to control breakthrough tremors which the DBS cannot handle.
      My understanding is that Caprylic Acid contains 1-Octanol, THE ingredient in alcohol that temporarily controls ET.

      July 20, 2012 at 12:10 | Report abuse |
  11. Joyce

    To PharmD: Thank you so much for the information about this study. I think it would be worth my while to get in touch, and see if anyone is interested in finding out if present IVIG patients for immunesuppresant diseases might be useful or enhance their study. I am grateful.

    July 19, 2012 at 09:27 | Report abuse | Reply
  12. weeble

    Research B-12 injections. Even when bloodwork shows B levels are normal, weekly injections (google the studies) for a couple of months show improved cognitive ability. So many people have B12 deficiencies and don't even realize it. My mother has moderate dementia, has had 6 weekly shots and is having far more 'good' days in a row then ever. Substantial difference.

    July 19, 2012 at 21:55 | Report abuse | Reply
  13. Joey Bill

    If truly effective, this medication should be provided gratis to Members of Congress

    July 20, 2012 at 07:48 | Report abuse | Reply
  14. carolae

    My husband, who is 72, was diagnosed with Dementia a few months ago. The doctor said that he was going to give him a medication in a few weeks that should help slow down the process. He is no longer able to drive and is depressed. His short term memory is very bad but no problem with long term. I don't believe there is any medication out there that could turn this dreaded disease around.....it is going to become more difficult as the Dementia progresses. It is noted that people die from this disease but causes the death? Is it something in the brain that stops and you lose all body functions? I know a man who is 85 and has Alzheimers and even though he can't remember much, he is still able to have a conversation with you, etc. This is one disease that hopefully one day, there will be a cure for. As for the so-called "trials", I heard that the person who signs up for that and is accepted, has to pay for it out of their own pocket! I always though trials were free to those who were chosen.

    July 20, 2012 at 09:28 | Report abuse | Reply
  15. Yes1fan

    "a rare population living near Medellin Colombia that is prone to genetically-caused, early onset Alzheimers"???
    And they think it's GENETIC there???
    Try drug-altered sub-humanoids....

    July 20, 2012 at 11:59 | Report abuse | Reply
    • ruralgoddess

      YesFan–I

      'd suggest you do your homework before making such a statement. The NYT had an excellent article about the study and about the people in the village where the early onset Alzheimer's strikes so many related people.

      "Drug-altered sub-humaniods"? If you're referring to Columbia's "problem" w/ drugs, you should be ashamed of yourself for accusing innocent people who suffer in this extended population of being the cause of their own misery.

      You reveal more about your own shortcomings in those statements: normal people have compassion.

      July 20, 2012 at 23:29 | Report abuse |
    • Fernando

      Nasty Yes1. This is where you gracefully explain what you really meant and apologize for the misunderstanding. You had plenty of time so I'll just pile on.
      I sure wouldn't wish Alzheimer's on you, Yes1fan.

      July 21, 2012 at 01:54 | Report abuse |
    • Jose

      Attended the Grand Prairie (Dallas) tour last night and all the dancers were exceellnt performers however, we miss the personalities of some of the past dancers (Twitch, Loren, Pasha, etc.) and some of the memorable special dances, just didne28099t seem to be as many with this seasone280a6 We enjoyed seeing some All Stars join in with the new ones. Plus they added some new music/skits and while I like watching Broadway e28093 even this older lady likes hearing more hip hop tunes. My friend and I did go meet the dancers after the show and they were all extremely nice, taking pictures with us. I will keep going year after year after year!!

      August 2, 2012 at 02:57 | Report abuse |
  16. Charles

    There has been some strong scientific evidence that alternative therapies may be helpful in treating Alzheimer's. Both Gingko and Sage help in alleviating the memory impairment associated with this debilitating disease. Pharmaceutical drugs are great, and I think we should constantly be developing them to be safer and more effective. However, I also think that we shouldn't overlook herbal supplements. Often times, the beneficial compounds in these herbs can be isolated and concentrated into a pharmaceutical pill.

    Note: These postings are my own and do not necessarily represent Natural Standard’s positions, strategies or opinions.

    July 20, 2012 at 12:49 | Report abuse | Reply
  17. Fernando

    Surprised the article didn't mention tumeric or curry. Very strong epidemiological evidence that it has potential to protect from Alzheimer's. Very low incidence in India.

    July 21, 2012 at 01:56 | Report abuse | Reply
  18. fritz

    Yikes! I'm past 60. I'm wondering when I'm going to get the mental heebie jeebies. I just hope I have enough cognitive reasoning left so I can off myself before I become vegefied. I have no intention of going through a second childhood as someone's or society's burden. i'd rather be nothing.

    July 22, 2012 at 13:22 | Report abuse | Reply
    • Cansever

      From Business Week: The past quarter-century has seen a reotiuvlon in finance. It's felt every time a homeowner refinances a mortgage or signs up for a credit card. No one person can claim to have lit the fuse for this reotiuvlon but Lewis S. Ranieri was holding the match. Joining Salomon Brothers' new mortgage-trading desk in the late 1970s, the college dropout became the father of securitization, a word he coined for converting home loans into bonds that could be sold anywhere in the world. What Ranieri calls the alchemy lifted financial constraints on the American dream, created a template for cutting costs on everything from credit cards to Third World debt and launched a multibillion-dollar industry.Salomon and Bank of America Corp. (BAC ) developed the first private mortgage-backed securities (MBS) bonds that pooled thousands of mortgages and passed homeowners' payments through to investors in 1977. Not a moment too soon: Skyrocketing interest rates were turning the business of savings and loans funding long-term mortgages with short-term deposits making it a financial death trap for banks just as the housing demands of maturing baby boomers began to surge.Ranieri's job was to sell those bonds at a time when only 15 states recognized MBS as legal investments. With a trader's nerve and a salesman's persuasiveness, he did much more, creating the market to trade MBS and winning Washington lobbying battles to remove legal and tax barriers.A less likely financial engineer would be hard to imagine. Ranieri, a Brooklyn native, set out to be an Italian chef until asthma ruled out work in smoky kitchens. A part-time job in Salomon's mail room set him on the path to trading. A large, volatile man, Ranieri built the firm's mortgage desk in his own image: fat guys, as author Michael Lewis described them in Liar's Poker, promoted from the back office, who indulged in feeding frenzies and practical jokes while selling strange new bonds to doubtful investors.But Ranieri also recognized that mortgages are math. He hired PhDs who developed the collateralized mortgage obligation, which turns pools of 30-year mortgages into collections of 2-, 5-, and 10-year bonds that could appeal to a wide range of investors. The homeowner in Albuquerque could now tap funds from New York, Chicago, or Tokyo, a change that Ranieri figures cuts mortgage rates by two percentage points. Soon everything from credit-card balances to auto loans was being repackaged.

      October 13, 2012 at 23:18 | Report abuse |
  19. Nicole

    After watching my grandmother suffer for 10 years with this disease that eventually took her life, I welcome SOMETHING that could help. I would never wish ANYONE to go through what my grandmother did. It broke my heart and if this could have helped her, I would have spent every dime in my pockets to make sure she got it.

    July 28, 2012 at 23:05 | Report abuse | Reply
  20. Walessb

    How come CNN has the same brain scan image marking changes in the brain for the Stutters story AND this Alzheimers study? You would think they would attempt to get the scans that were included in the published study. Seeing the exact same changes in the brain for both stories is misleading.

    August 21, 2012 at 22:04 | Report abuse | Reply
  21. Frank

    You can sometimes restore memory in 1/2 hour with B vitamins.. If you want to improve cognition and memory and patience try a pinch of Turmeric..It breaks down plaque in your nerves and works for your whole body, smoothing things out. For improving thought processes and memory try B-12.. It'll sometimes gives a sense of well-being, which can come in handy. A pinch of sage can improve short term memory and problem solving capabilities. It works on the acetylcholine. I read that actual dementia is caused by different types of deterioration of the hypothalamus, each of a different presentation. I don't know how the above would affect the different types of demetia..

    February 21, 2013 at 22:42 | Report abuse | Reply

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