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Study: Weight-loss combo pill shows promise
April 10th, 2011
06:30 PM ET

Study: Weight-loss combo pill shows promise

Two existing drugs, in combination, have shown significant promise in promoting weight loss, according to a new report.

The drugs,  phentermine and Topamax, in combination with lifestyle and weight-loss counseling were associated with a 18-22 pound weight loss in trial participants, compared with a three-pound weight loss in patients who received counseling alone.


The drug also appears to have reduced other obesity-related indicators, such as blood pressure, cholesterol and inflammation levels.

By comparison, the only approved long-term prescription weight loss medication available on the market today, Xenical, is associated with a seven-pound weight loss when combined with diet and exercise.

The study was funded by the pharmaceutical company Vivus, which combined the two drugs into one pill called Qnexa, and petitioned the U.S. Food and Drug Administration for approval in October 2010. The Food and Drug Administration denied the request, asking for more safety data from the company before moving forward.

According to the report, there were specific concerns about each drug's safety individually; specifically Topamax, which is reported to cause some psychiatric and cognitive side effects and may cause clef palate birth defects if taken while pregnant.

According to the manufacturer's study, the two drugs, when taken together, and at controlled-release doses, were very safe. Participants in the trial reported minor side effects such as dry mouth and constipation, however at higher doses, some participants did complain about some psychiatric side effects.

Among the 2,487 study participants, nine became pregnant, and none of their children were born with cleft palates, the report said.

The drug could be a good option for some people, but it's most likely not a silver bullet, said Dr. Melina Jampolis,  CNNHealth's physician nutrition expert, who is not connected with the study.

"This might be a good tool in the short term to get someone motivated, and that's great," she said. "But unless it's paired with aggressive lifestyle changes, it may not be great in the long term."

Phentermine is commonly used as a short-term weight loss treatment, and was previously paired with fenfluramine to make the successful but now-discontinued weight loss drug Fen-phen. Fen-phen was removed from the market in 1997 amid concerns about the drug's heart risk, but phentermine has been used successfully for short-term appetite suppression since then with no major safety concerns.

Topamax is commonly used to treat migraines and seizures.


soundoff (402 Responses)
  1. Marianne

    Everyone please give a round of applause to Pete and Lori, they have solved the age old mystery of being overweight.

    April 11, 2011 at 10:45 | Report abuse | Reply
  2. DisgruntledGrrl

    Stupid question: Why are women taking diet pills while pregnant?
    I'd be tempted to take this because I have no plans to be pregnant ever and this Thyroid issue is really making it hard to lose weight. My husband and I eat at the same time and nearly the same amount, heck I eat less at times and he's 206 on a 6'3 frame while I'm 211 on a 5'2 frame. South Beach didn't help after 4 weeks.
    But Macik's post does give me pause. They didn't REALLY cover the side effects here other than something to scare birthers.

    April 11, 2011 at 10:46 | Report abuse | Reply
  3. Jane

    Oh my God Pete and Lori, you're going to be famous.

    April 11, 2011 at 10:46 | Report abuse | Reply
  4. Marcus

    Pete and Lori, are you guys related? Cause you both sound like a couple of goof balls.

    April 11, 2011 at 10:47 | Report abuse | Reply
  5. Jon

    It is a simple question of mathematics: If you burn more calories than you intake, YOU WILL LOSE WEIGHT...YOU HAVE TO. Netting a negative caloric balance can be achieved several ways. 1. Intake few enough calories that your normal metabolism burns more than you eat. 2. Eat as many calories as you like, but exercise enough that you are burning more than you intake. 3. (Best Option) Moderate your eating habits and the amount of calories that come from fat while exercising at least one hour a day, every day to burn more calories than you intake.

    But at the end of the day...its simple math.

    April 11, 2011 at 10:50 | Report abuse | Reply
    • DisgruntledGrrl

      Well .. for men. Ya see, Jon, women are geared towards holding more fat reserves than men because we have to sustain children. My husband and I are actually on a bet starting today (he had strep throat last week) where we'll exercise every day for 20 minutes and have an hour "walk" with our pitbull through a squirrel infested park every Sunday. The bet is that he will lose at least 6 pounds and I won't. I should at least lose a pound due to being dragged, though (joke).
      We went through this on South Beach. Sadly, the constant dizzy spells hitting both of us were too much after 4 weeks. 4 weeks on South Beach and matching my husband calorie for calorie on meals – though I drank water while he cheated and drank soda – I lost 1 pound to his 10.

      April 11, 2011 at 11:08 | Report abuse |
    • Read

      @Grrl – 4 weeks on a fad diet is not an actual attempt at weight loss.

      April 11, 2011 at 15:23 | Report abuse |
  6. Darvin

    Stop the presses! Pete and Lori have found the secret to losing weight!

    April 11, 2011 at 10:52 | Report abuse | Reply
  7. Jerri

    Yep, topamax is terrible for cognitive behavior. My husband was on it for epilepsy and it was so stupid on it. He would forget the most basic things. He'd ask me a question and two minutes later ask me again. Once he was off it, it was light night and day!

    Perhaps the combo is a low dose of the drug!

    April 11, 2011 at 10:53 | Report abuse | Reply
  8. CNNreader

    All this drug market is just a conspiracy to keep people in pharmaceutical pockets and get them to buy this and that other drug, look at it, one pill will make ur headache go away while its side effects will destroy your liver, then u take another pill for the liver which in turn will mess with your brain, then u take another to counterattact the brain issue while the same pill screws up your stomach or nervous system. Its all about keeping you in the market and buying pills......

    April 11, 2011 at 10:57 | Report abuse | Reply
  9. Jed Rothwell

    The extreme obesity shown in the photo here was rare in the 1950s and 1960s. It began in the 1970s with the growth of fast food. People back in the 1960s did not exercise much. Middle-aged WWII vets hardly exercised at all - they figured they had enough of that in the war, I guess. Most people did not watch their weight or restrict their diet. We ate as much as we liked, and the food tasted much better than it does now. Yet when you look at photos of ordinary people on the streets back then, you seldom see the kind of fat people who are everywhere today.

    The only thing that has changed is fast food, and things like candy and cokes at every gas station and school.

    I never eat fast food. It tastes like industrial slop to me. I eat exactly the same diet I did as a kid back in the 1950s. Not health food or restricted diets, just ordinary wholesome American food, the kind people ate back in 1900. I have not gained or lost a pound in 30 years. If people would simply stick to traditional diets and lifestyles, and exercise reasonably, most of us will soon get back the average weight we had 50 years ago. There is no need for drugs, pills, surgery, guilt, or painful self denial.

    April 11, 2011 at 10:57 | Report abuse | Reply
    • DisgruntledGrrl

      And High fructose corn syrup! Don't forget that. You are totally right, Jed. Heck Pepsi is trying out "throwback" to remove the corn syrup and using just straight up sugar.
      There's so much garbage in food. A friend watching her intake due to Grave's disease is having a low soy tolerance. She found out soy lecithin is used to coat her tea, so they can use cheaper crap, and treat it more roughly. Preservatives are out of control here.

      April 11, 2011 at 11:23 | Report abuse |
  10. BILBO BOOMERBOTTOM

    Two words: Weight Watchers!

    April 11, 2011 at 10:58 | Report abuse | Reply
    • Darvin

      Two words, Screw You!

      April 11, 2011 at 11:04 | Report abuse |
  11. dc

    goes to show how ignorant you and the others are. Not everyone who is fat has stuffed their faces and eats junk all day. What a moron..

    April 11, 2011 at 10:58 | Report abuse | Reply
  12. Zoe

    I've taken Topamax for migraines, and I wouldn't wish it on my worst enemy. You can't think straight on that stuff. Words don't come out right, your body is constantly tingling, nothing tastes right (even water tastes strange). I almost lost my job due to the mental fog Topamax put me into, and I was on a relatively low dose. The dose you'd need to take to realize major weight loss benefits would have to be close to what people take to treat epilepsy, and as the dose goes up, so do the side effect, which take a LONG time to wear off after discontinuing use.

    April 11, 2011 at 10:59 | Report abuse | Reply
  13. Victor

    Two things not getting emphasized are (1) the weight loss of 22 lbs would not do a whole lot for most obese people who are far more than 22 lbs overweight; (2) if counseling only helps people lose on average 3 lbs that says something about the effectiveness of counseling and (3) what happens to all the test subjects when they went off the drugs...did they keep the weight off or put it back on.

    April 11, 2011 at 11:00 | Report abuse | Reply
  14. crafty cathy

    My daughter was on Topamax for migraines, and went from getting A's in math (her favorite subject) to D's. She'd forget words mid-sentence and couldn't even function at school. She eventually decided she'd rather deal with the pain of her non-stop migraine than continue having the side-effects she had from this drug. DON'T TAKE IT!!!

    April 11, 2011 at 11:01 | Report abuse | Reply
  15. Chase

    It is so simple, but yet not simple. I understand that it is hard to get into the grind of exercising and eating right. But, a dedicated 3-6 months of your life could have your obesity problems fixed. People try these drugs and eating a salad to counter the burger they ate the day before. That takes just the same amount of discipline to remember to take your pills and still watching what you eat, but with less outcome.

    It is simple EXERCISE!!!!!! you have to work out. You have to burn calories. You have to spend a couple of hours sweating your ass off. And you have to eat right and less take. It is tough I know, but if you dedicate 6 months of your life to exercising everyday ( with some offdays to recover), it is far more affective than spending 10 yrs trying different diet pills and jenny craig diets.

    What a lot of people do not get is exercising will not only make you thinner or bigger depending on what you want, but you gain so much energy. You become a happier person and that will also make you feel and look healthier. Exercise is a must..bike riding, running, swimming, gym, etc.!!!!!

    April 11, 2011 at 11:02 | Report abuse | Reply
  16. Ben

    One thing not being mentioned in this article at all is how bad Topamax is on your kidneys. I had to take this drug for prevention of cluster headaches. Within 3 months, I had experienced kidney stones as well as the first stages of kidney failure. Had to ween myself off to get my kidney's healthy again. You cannot quit this drug cold turkey also as you can face withdrawal. I think it's irresponsible of the writer to give people of the hope of weight loss in a pill without the badly adverse side effects.

    April 11, 2011 at 11:09 | Report abuse | Reply
  17. Jan

    Copy cat, copy cat, copy cat.

    April 11, 2011 at 11:12 | Report abuse | Reply
    • Jan

      Frankly Speaking is gay.

      April 11, 2011 at 11:57 | Report abuse |
  18. ThinkPeopleThink

    Wasn't Phentermine the "PHEN" in Fen-phen that caused heart valve damage in the mid 90's???

    April 11, 2011 at 11:16 | Report abuse | Reply
    • ReadPeopleRead

      It says so in the next to the last paragraph.

      April 11, 2011 at 11:29 | Report abuse |
    • Jerry

      It was actually the Fenfluramine that caused heart/valve problems.

      Phentermine is still available by itself in most countries, including the U.S. However, because it is similar to amphetamines, it is classified as a controlled substance in many countries (including Australia). Internationally, phentermine is a schedule IV drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act. Source: Wikipedia

      April 11, 2011 at 11:54 | Report abuse |
    • Tiffany

      this is not good. They need to put out a full disclosure about these meds. Topamax is an anti-seizure medication also used to treat migraine headaches. My dr put me on it for migraines. What he didnt tell me was that anti- seizure medications have had a link to birth defects in babies. While I wasnt on the medication when I got pregnant (stopped taking it a few months before) my child developed a fatal neural tube defect. Please please please read the fine print if you consider taking anything with Topamax.

      April 11, 2011 at 12:26 | Report abuse |
    • DRV

      Why not repeat the study with Phentermine or Phendimetarzine alone? Both are generic and very inexpensive. Oh wait... Topamax is $$$ and will benefit the pharma company.

      April 11, 2011 at 13:40 | Report abuse |
    • Fiona

      Tiffany, if you went off the drug two months before getting pregnant, the drug was out of your system. Neural tube defects are statistically more likely to be due to a lack of folic acid in your diet. Were you taking prenatal vitamins at the time that you were TRYING to get pregnant? Or a folic acid supplement? I'm sorry for your loss, but you are blaming the wrong thing.

      April 11, 2011 at 16:29 | Report abuse |
  19. Bulimic Now After Seeing that Picture

    Pete's right. I totally threw up like 2 pounds worth of food after seeing the picture for this article. See now if only they could come up with a pill that would help obese people feel the shame associated with their gluttonous appearance and lifestyle then maybe they would feel as disgusted with themselves as we feel by having to look at them. Sorry to make it seem like I'm hatin' on fat people, but seriously, how can you let yourself get that OUT OF CONTROL? If it were a strung-out looking meth addict a similar level of public intervention might be needed. But overweight people think too highly of themselves to allow themselves to be placed in the same category as other addicts in desperate need of help. Maybe if they'd stop letting their ego and unrealistically high self-esteem get in the way of them getting some help, then they wouldn't be in this position. I think one of the WORST movements to come out of the last decade was the empowerment of fat people and them trying to convince the public that "big is beautiful" and that we should embrace them for how they are instead of trying to convince them to change (and lose weight and get HEALTHY). But that's like a coalition of meth addicts joining together to convince the public that their rotted teeth, pimpled, gaunt face, and stringy hair is beautiful and that the public should be ashamed of themselves for trying to convince the meth addicts to change, get healthy, or get help. Fat people need to get over themselves and GET HEALTHY and the public needs to wake up and see that OBESITY IS NOT BEAUTIFUL!

    April 11, 2011 at 11:16 | Report abuse | Reply
  20. Claudia, Houston, Tx

    CHASE is right, and we need to use his weight loss advice. EXERCISE.

    April 11, 2011 at 11:16 | Report abuse | Reply
    • Rita

      I I Agree. I was overweight and simply started to exercise and eat right and came from a size 12 to a size 2 in two years. Yes it took a lot of time, but I did it the healthy way. But most people are just too lazy to get out of the couch and move their legs a little...or are addicted to instant gratification!

      April 11, 2011 at 12:16 | Report abuse |
    • todd

      I cut out the cupcakes and chocolate truffles. Went from waist size 32 to size 29 – weight went from 170 to 150. I'm a 5'6" male. Also increase exercise.

      No drugs, just effort and willpower. Not easy, but very simple.

      April 11, 2011 at 15:33 | Report abuse |
  21. SMANCometh

    Listen up People, and listen up good. Our bodies were not designed to have the kinds of foods thrown into it at the amounts consumed. Our bodies were not designed to sit at a desk all day stairing at a computer screen. We have muscles that were designed to be moved. It's tough, I know, and the older we get the tougher it is but we have to get moving and eat sparingly. Do you think cavemen ate three square meals a day..no they ate when they had food and they often went hungry and had to move alot to get their food. Think about it. For those of you that haven't tried it yet, water fast for a couple days a week for 24 hours and see if that gets rid og your belly.

    April 11, 2011 at 11:16 | Report abuse | Reply
    • clyde

      but, food id so yummy !!!! water is not enough !

      April 11, 2011 at 11:30 | Report abuse |
    • Denizen Kate

      First of all, do we really want to go back to being neanderthals?

      Secondly, your advice about fasting is downright dangerous. Do you have a medical degree? If not, stop giving out such bad advice. The reason fasting is a bad thing is that, once you finish the two or more days of fasting and begin eating again, your body tends to store every morsel as fat, in fear that you will starve it again. That decreases your metabolic rate and makes it forever more and more difficult for you to lose weight with good diet and exercise habits.

      April 11, 2011 at 11:53 | Report abuse |
    • Chuck

      I agree with what you said. However, you mentioned twice about our bodies being "designed" – a reference to creationism. And then you talk about cavemen – a reference to evolution. No particular point. I just thought that was interesting...

      April 11, 2011 at 12:02 | Report abuse |
    • Sluggo

      Shut up you sanctimonious twit.

      April 11, 2011 at 13:37 | Report abuse |
    • Mance Lotter

      Chuck – very good pickup on a subtle point. I would like to point out, however, that as someone who believes in a Creator, I also believe in evolution (i.e., the two don't have to be exclusive of each other).

      April 11, 2011 at 13:37 | Report abuse |
    • Correlia

      Last I checked cave man's life expectancy wasn't 78 years...

      April 11, 2011 at 13:54 | Report abuse |
    • Read

      @Correla – someone who weighs 300 pounds doesn't have a life expectancy of 78, either!

      April 11, 2011 at 15:26 | Report abuse |
    • todd

      Water-fast? Yeah that will get rid of your belly, because the body will break down muscle before it breaks down fat. You are not a medical doctor, that is painfully clear.

      April 11, 2011 at 15:35 | Report abuse |
    • Cjos1

      SManCometh...recommending water fasting for 3 days is dangerous!!You could lose up to ten pounds or so, but you would immediately gain all of this weight back. Also, because you would be going days without vital nutrients, your body would be in a state of shock once you finally began to eat again. Your body, thinking that it is starving, will pack every ounce you eat into fat incase you starve again. So, whenever you fast, if you don't drink enough liquids and get all of your vitamins and nutrients, you end up gaining all of the weight back and then some in fat storage. Also, it's easy to lose muscle mass when you fast, so watch out for that one if you're an athlete.Do Not do any fasting without checking with your physician!! SManCometh you should be careful with your opinions, people of different ages have different issues all-together, you are Not a Doctor and could harm somebody by trying to control them with guilt for weight gain! Topamax as with any drug can/has side effects, which are different for everybody. I took it for severe migrains and yes it did work for the migrains and even assistant in weight supression,(not that I needed it!) however it cause me serious kidney issues to the point of suspending the medicine. Any medicine regiment should be supervised by your physician!

      April 11, 2011 at 20:59 | Report abuse |
    • John

      Read the post he said fast for 24 hours 3 times a week. It does seem a too often for a fast but I also agree a periodic fast is a good thing.

      July 10, 2011 at 15:39 | Report abuse |
  22. Brenda

    I used Topamax (a very low dose and built up) for migraines and the side effects were horrendous! It can act as a mild depressant. I did lose weight, was down to one meal a day, couldn't sleep, and having panic attacks. I had no hunger but I also barely had the will to live. These drugs are serious and after you've had a severe reaction to one of them you realize your migraines/obesity/whatever reason you're taking the drug for, is much easier to deal with. Topamax is also for seizures so I can see using it for that, but just to lose weight? NO WAY! I feel for the study participants. I'm sure the ones who thought they were going out of their mind didn't see the effects as minor.

    April 11, 2011 at 11:20 | Report abuse | Reply
    • Sonja

      I have been taking Topamax for years for migraines, and have never had any side effects (and yes, it got rid of my migraines as well). Different people have different reactions – I know people who reacted badly to Advil. As long as warnings are there, it's good they're making progress on this issue.

      April 11, 2011 at 11:51 | Report abuse |
    • Mugsy

      Reading the posts shows that Topomax is not a good way to lose weight. I took it for week. It put me in the hospital with suicidal thoughts. It does not mix well with anti-depressent medicine. Becareful if you use this. We need to back away from all the preservatives, it is true that our bodies are not meant to eat all this crap. Back to Basics

      April 11, 2011 at 11:52 | Report abuse |
    • Dromard

      My wife is on Topomax for migraines. The drug hasn't relieved all her pain, but it is manageable. However the cognitive side effects are pretty bad. She has short-term memory issues and word-finding difficulties. Pain-wise she could probably return to work, except the cognitive side effects prevent her from doing so. Her neurologist says Topomax is a "workhorse" migraine medication, but hopefully we can find her an alternative. I don't recommend it for longterm usage.

      April 11, 2011 at 13:35 | Report abuse |
    • Linka

      I took Topomax for a week to try and help with migraines, it was awful. Suicidal thoughts, carbonated beverages tasted horrible, lost the taste for food at all. I was a sobbing mess three days into it. Stopped taking it after 7 days, would never touch it again. It is another case of rebranding a psychiatric medication to prolong the patent and keep making top dollar for the med. Check out the studies on the drug, they found this worked for weight loss as a side effect of using it as a psych med. Same for Wellbutrin and Chantix. It is a way to keep the drug from going generic losing the money.

      April 12, 2011 at 16:19 | Report abuse |
  23. epona30

    Topamax makes food taste bad. My husband had to take it for severe migraines. It also made him very detached and angry. He would either be totally unemotional or a basket case. Just asking him a simple question made him made. and he is normally the sweetest, level headed person I know. He stopped taking at my request because I was afraid of him while he was on it.

    It will make you lose weight, but its probably better to just eat healthier.

    April 11, 2011 at 11:24 | Report abuse | Reply
  24. Larry Nunn

    Why take the chance with these drugs. Skinny Fiber has three natural ingrediants that are allowing people to lose weight quickly without any side effects.

    April 11, 2011 at 11:24 | Report abuse | Reply
  25. ak

    Clen, T3, DNP, Epidrine, HCG. All effective weight loss drugs with no long term effects like all these complex pharmaceuticals. .Unfortunately they are all illegal (because they are cheap, safe, and effective).

    April 11, 2011 at 11:27 | Report abuse | Reply
    • clyde

      They are illegal because they are dangerous.

      April 11, 2011 at 11:31 | Report abuse |
    • sherrie0824

      They are illegal because idiots mis-used them. I have my dwindling supply of epedrine; I don't know what I'll do when I run out. Overseas maybe? Because the pills WORK and I don't want to go back to the way I was before them.

      April 11, 2011 at 12:27 | Report abuse |
    • Gee

      HCG is not illegal. To get an effective dosage you need to see a medical doctor.

      April 11, 2011 at 12:29 | Report abuse |
  26. Bulimic Now After Seeing that Picture

    I also want to tackle the problem we're having with gay people flooding the media with non-important requests for legalizing marriage.

    April 11, 2011 at 11:29 | Report abuse | Reply
  27. Bulimic Now After Seeing that Picture

    I'm also gay myself by the way.

    April 11, 2011 at 11:31 | Report abuse | Reply
  28. Laurent Gbagbo

    Nice idea Pete! The strategic positioning of this photo on fridges and cupboards across the nation could prevent thousands of would-be blimps from stuffing their faces with Cheez-its and Twinkies. In fact, placing this photo on junk food packaging could deter fatties in the same way that health warnings on cigarette packages supposedly work to deter smokers. Pete, far from being a "moron" or a "goofball", I think you're on to something. Great contribution!

    April 11, 2011 at 11:31 | Report abuse | Reply
  29. Laurent Gbagbo

    But it would not solve the problem of gays in the military.

    April 11, 2011 at 11:34 | Report abuse | Reply
  30. Pete

    Laurent Gbagbo, get your own ideas loser.

    April 11, 2011 at 11:35 | Report abuse | Reply
  31. Lori

    My my what a bunch of stuck ups we have in here. Do you really think anybody cares about fat people?

    April 11, 2011 at 11:38 | Report abuse | Reply
  32. Laurent Gbagbo

    Pete! I'm hurt. You finally found a supporter in the one true Laurent Gbagbo and this is how you react? I'm starting to think that you might be a "moron" and a "goofball" after all.

    April 11, 2011 at 11:43 | Report abuse | Reply
  33. Bulimic Now After Seeing that Picture

    OBESITY IS NOT BEAUTIFUL! I understand that overweight people have a difficult struggle to get themselves healthy again. It is probably on par with how difficult it is for drug addicts to get sober. But there is NO excuse for obese people to go around saying that big is beautiful and they like themselves this way. That's the same excuse drug addicts use – that they don't NEED to change. But just because the "drug" that obese people are addicted to is legal (food) doesn't make the effects of it any less devastating than the effects of illegal drug abuse. Society needs to wake up and stop AFFIRMING overweight people's position that they don't need to change. They DO Need to change – they're sick, they are NOT HEALTHY, and they need help. Oh, and this post along with my first post are the only two written by me. The other person posing with my screen name of "Bulimic Now After Seeing that Picture" and posting short comments about gays is not me. But I do strongly support gay rights and the rights of gay to marry, just in case anyone was curious.

    April 11, 2011 at 11:44 | Report abuse | Reply
  34. elivet

    be confident abopur your selves while ur skinny or fat everyones is preetty and beutifull.... the outside is not the only thing that matters.. one of the most important things is the inside... looks dont matter looks arent gonna make u succed in like but your personality will.......

    April 11, 2011 at 11:44 | Report abuse | Reply
    • Frankly Speaking..

      you must be fat

      April 11, 2011 at 11:51 | Report abuse |
    • Rita

      There's no such thing as fat and beautiful or fat and happy... I've been there. I was fat and miserable and I was not pretty. You'll look beautiful and happy when you get healthy! I'm not talking about scary skinny, but healthy weight.

      April 11, 2011 at 12:29 | Report abuse |
    • Morfy

      Rita, that's you. Your experiences do not account for everyone's.

      April 11, 2011 at 13:07 | Report abuse |
    • todd

      It may be possible to be fat and happy or fat and beautiful. It is NOT possible to be fat and healthy. That alone is reason enough to lose the weight.

      April 11, 2011 at 15:37 | Report abuse |
  35. Pete

    Oh my, I'm going to cry.

    April 11, 2011 at 11:49 | Report abuse | Reply
  36. Bulimic Now After Seeing that Picture

    Lori & Laurent Gbago, I think we have a saboteur on the comment board posing as other posters. I think the mean reply you got from "Pete" was not the same "Pete" that started the comment string. I know a couple of comments have been posted using my screen name that were not from me. So just keep that in mind. It's probably just an obese person sitting at home on their couch/bed doing the only kind of activity they can do without breaking a sweat – typing on a keyboard. Worse yet, it's probably OUR tax dollars that are paying this person's disability check so they can sit at home and be fat and unproductive for the rest of their life. But yeah, when we take to the comment board to openly discuss such things all of these other people come out against us like WE'RE the bad, mean people! Fat people just do not like to be called out on their out of control lifestyle. But hey – IF THE TRUTH HURTS.....!

    April 11, 2011 at 11:51 | Report abuse | Reply
  37. Pete

    Laurent Gbagbo, what race are you? Your name doesn't look American.

    April 11, 2011 at 11:52 | Report abuse | Reply
    • Thinks2010

      Pete–Laurent Gbagbo is the name of the leader of Ivory Coast that was toppled this week. My guess is that some joker thinks he is being clever by using it here. Of course, it may be a more common name than I think, but I still think its a phony.

      April 12, 2011 at 19:47 | Report abuse |
  38. ranch111

    How about eating less and quality food instead of inventing drugs? Stop eating the processed foods.

    April 11, 2011 at 11:53 | Report abuse | Reply
  39. Bill Bobaggins

    How much did Ortho-McNeil pay for this advertisement? And, there is no "magic pill" out there, people. If you want to lose weight, get off your ass (that's a start), and exercise. Stop eating at McDonalds. Watch your calorie intake. Stop drinking soda. Eat small meals. Snack on fruits. Like a previous poster stated, our bodies weren't made to consume as much food as we do nowadays. Nor were they meant to sit behind a desk (or television) for 8-18 hours a day.

    April 11, 2011 at 11:53 | Report abuse | Reply
    • GCMike

      Damn right you little hobbit.

      April 11, 2011 at 12:06 | Report abuse |
    • JB

      Bill B.,
      whole problem about losing weight is that each person can have different reason for being over weight, it my not be because a person is sitting on there back side or what ever other term you used, you need to quit judging others and have compassion for others, and remember that each individuals story or reasons are different. I'm sure you have something about yourself you don't like or think other are seeing different then you are. The heart is what is improtant . I think you need to grow up and realize that there are people who are offended by your uneducated remarks. You are very hurtful to alot of people looking for a friend or help.

      June 26, 2011 at 19:23 | Report abuse |
  40. L

    I took Topamax for migraines and it was the worst drug. I did lose weight on the drug and that was the only wanted side effect. I became suicidal and my doctor thought I was crazy since at the time there was no proof of that side effect. It may not effect all people this way and it is hard to notice the change at first. Make sure if you take this drug people know it and can tell you if they notice mood changes.

    April 11, 2011 at 11:54 | Report abuse | Reply
    • Kristy Bragdon-Bill

      did you get the "unexpected and sever rage" side effect too. that one was just lovely (only happens in .1% of patents). any little thing happens and you get severally angry. I asked my doc to lower my dose because i thought i was gonna end up hurting someone (and i had a small child at the time)

      April 11, 2011 at 12:05 | Report abuse |
  41. trumod

    "Psychiatric side effects" but you can wear a size 2. It'll be a big hit.

    April 11, 2011 at 11:56 | Report abuse | Reply
  42. Kristy Bragdon-Bill

    I was put on Topamax for headaches and lost about 25lbs in less then 2 weeks I did not exercise or diet at all. Now most would see this as a good thing but heres the problem... i am only 5'3" and i started out weighting only 115lbs. I went down to about 92lbs and it has been 1 year since i stopped taking it and no matter what i do i can't put the weight back on and my potassium level is WAY down (to the point of daily muscle cramps and "hazy" feelings) and my heart rate bounces between tachycardic and bradycardic and a Echocardiogram, Holter Monator and EKG later they still can't find a reason for it. To those that would consider taking this for weight loss I think you should skip it and just diet and go to the gym and be patient. You didn't put the weight on overnight so why expect to loose it overnight?

    April 11, 2011 at 12:02 | Report abuse | Reply
  43. Pete

    Bulimic Now After Seeing that Picture, no still me me, no impostors here. Just people with lack of ideas. I just don't like people that don't have their own ideas. You mean you can't believe someone doesn't agree with you and therefore are impostors? Get off your high horse idiots.

    April 11, 2011 at 12:03 | Report abuse | Reply
  44. Bulimic Now After Seeing that Picture

    I don't believe you are the real Pete. It's no shame on being fat people. I agree with Lori and Pete you can kiss my a s s if you don't agree anymore. But I for once am sticking to the idea that everyone that's fat can change their minds without a pill. I mean come on! If winos can stop drinking and drug addicts can quit, so can fat people stop eating. As for gays in the military that's another discussion for another time.

    April 11, 2011 at 12:06 | Report abuse | Reply
  45. Laurent Gbagbo

    Bulimia, I think you're right. The true Pete would never say such ignorant and alienating things.

    To the impostor: we were having a civilized, enlightening discussion until you arrived. You have obstructed our quest for true, intellectual progress, an inexcusable sin with which you will have to live for the rest of your life. For shame!

    April 11, 2011 at 12:08 | Report abuse | Reply
  46. Turtle Soup

    Actually, pasting photos like the one in the article onto your fridge has been shown to have the opposite effect. People look at it and say to themselves (I am still okay, because I am not as fat at the person in the photo. What has shown to be effective instead, is to post a photo of a hot, in shape woman or man in a swimsuit. You will feel fat when you compare yourself to the photo, giving you something to strive for.

    April 11, 2011 at 12:10 | Report abuse | Reply
  47. Lori

    Laurent Gbagbo, you sound like a loser. I agreed with Pete but not with your stupid ideas, same goes for Bulimic Now After Seeing that Picture. You guys are just mean!

    April 11, 2011 at 12:11 | Report abuse | Reply
  48. Junior

    go work out... you lazy people

    April 11, 2011 at 12:12 | Report abuse | Reply
    • John

      I was working 60 hours a week and over weight 2 days a wee 9am to 10pm if I worked a weekend I worked 9am to 10pm Fri Sat 9 to 6, sun 10-6. Was I lazy? Finally hCg has been the answer, down 90 lbs.

      July 10, 2011 at 15:46 | Report abuse |
  49. Lori

    Pete, I am white. And proud of it, I would kill myself I had been born a different race.

    April 11, 2011 at 12:13 | Report abuse | Reply
  50. Pete

    I have to apologize to everyone. I really weight 450 pounds and hate myself. I am lazy and haven’t been out of my mom’s basement in more than a month. It’s been even longer since I have showered. I apologize again for reflecting my self-hate onto this message board.

    April 11, 2011 at 12:13 | Report abuse | Reply
    • GCMike

      you don't have any skinny hostages down there do you?

      April 11, 2011 at 12:17 | Report abuse |
    • md2205

      I think someone has to reply to his man to help him start coming out of his fog. He sounds depressed and is reaching out for help. I think he needs to know that there is someone out there who might be able to help him so that he can motivate himself to lose the weight and take care of himself so he can start to live normally again. Sometimes people can feel paralyzed when they think doing something is too hard to do; but he will feel so much better if he will just start something. Even if it is to get out of the house and join a gym. Some gyms might give people private sessions during off hours if he is too embarrassed to be seen. Maybe he could call gyms around his area to find out. Or just go early in the morning when most other people will not want to go.

      April 12, 2011 at 00:47 | Report abuse |
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Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.