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June 2nd, 2010
10:38 AM ET

Spray may treat premature climax

By Elizabeth Landau
CNN.com Health Writer/Producer

It's fitting that "PSD502" sounds like a code name, since it relates to a distressing problem most men would prefer not to talk about: premature ejaculation.

Researchers recently presented findings on PSD502, a topical spray medication, at the American Urological Association Annual Meeting. The spray, made by pharmaceutical company Shionogi Pharma, Inc., is in trials among men who suffer from premature ejaculation.

Participants were selected from 70 centers in the United States, Canada and Europe to use either this spray or a placebo spray. They were told to put the spray on the glans penis - the conical structure at the tip of the penis - five minutes before intercourse. Data came from two studies, each of which had more than 500 men.

Researchers found great improvement, with an average time of 3.3 minutes to penetration and climax among those who used PSD502, representing a 5.5-fold increase over the baseline of 36 seconds. Participants who used the placebo had a 1.6-fold gain in time to ejaculate.

The spray itself does not work magic with new materials; in fact, it is a combination of two drugs currently on the market for pain relief: lidocaine and prilocaine.

The company is in the process of applying for approval from the U.S. Food and Drug Administration and could not yet estimate when the product might be available to consumers.

There is currently no FDA-approved treatment for premature ejaculation.

Between 5 and 30 percent of men experience premature ejaculation, studies have found. Risk factors for premature ejaculation include erectile dysfunction, stress, other health problems and use of certain medications such as psychotropic drugs.

Learn more about premature ejaculation from the Mayo Clinic.

Editor's Note: Medical news is a popular but sensitive subject rooted in science. We receive many comments on this blog each day; not all are posted. Our hope is that much will be learned from the sharing of useful information and personal experiences based on the medical and health topics of the blog. We encourage you to focus your comments on those medical and health topics and we appreciate your input. Thank you for your participation.


soundoff (88 Responses)
  1. eman

    This is nothing new. They have been selling products containing Benzocaine in sex shops for DECADES. This spray simply uses alternate anesthetics that are commonly available over the counter..

    June 2, 2010 at 12:44 | Report abuse | Reply
  2. Tracy

    Ok, so they're helping all these men; so who are the men having hours of sex with when there is virtually very little to no help for women's sexual dyfunction (which by far excedes men's)????

    June 2, 2010 at 13:22 | Report abuse | Reply
  3. Craig

    Tracy, last I read (albeit years ago) one of the major problems women complain about is that their men don't last long enough to bring their sig-others to climax. Don't you think this is win-win?

    June 2, 2010 at 13:42 | Report abuse | Reply
  4. Scott

    for heaven sakes Tracy – lose the bitterness – this is an article about premature ejaculation. Why would you imply that men are having hours of sex with others.

    June 2, 2010 at 13:44 | Report abuse | Reply
  5. Rob

    Tracy, I was wondering the same thing myself. What good is a product that'll make me a stud in bed when 36 seconds is about all my wife can take?

    June 2, 2010 at 14:06 | Report abuse | Reply
  6. Barry

    For those who are fortunate enough to be able to climax multiple times, it is beneficial to simply begin another round of intimacy after the premature ejaculation. Because the amount of time it takes to achieve the second climax is generally far greater it provides one's partner to be able to enjoy intimacy equally. However, I want to add that this is NOT the first product of its kind - maybe just the first to make it into the news.

    June 2, 2010 at 14:12 | Report abuse | Reply
  7. froggy

    A baseline of 36 seconds? Wow. It's like the announcer at a racetrack shouting "And they're o... it's over ladies and gentlemen, it's over."

    June 2, 2010 at 14:31 | Report abuse | Reply
  8. ArrKay

    Tracy, if anything, wouldn't enabling men to not have premature ejaculations at least help women...?

    June 2, 2010 at 16:39 | Report abuse | Reply
  9. Zoe

    Tracy, we couldn’t agree more – so much of what we see today about sex (articles, solutions, etc.) is from a male point of view and that’s why at Zestra (www.zestra.com), we’re trying to help women feel comfortable talking about sex …having it, not having it, and what they can do to make it better. In a world where men have multiple options like Viagra and Cialis readily available, and soon maybe PSD502 too, the opportunity to improve women’s sex lives and provide them with a safe space to talk about it just makes us plain giddy.

    June 2, 2010 at 16:57 | Report abuse | Reply
  10. Jesse

    If you're going to take issue with too much work going to male sexual disfunction and not female, then i have to take issue with the massive disparity in funding for cancer research. Why is it that the vast majority of funding goes to breast cancer when it already has a 90%+ success rate. What about the rectum, pancrease and so on. Can't we all just agree that anything that makes people feel better is a good thing?

    June 2, 2010 at 18:09 | Report abuse | Reply
  11. Fred

    36 seconds? Something is wrong. Did the men studied have sex partners or placebos?

    June 2, 2010 at 18:26 | Report abuse | Reply
  12. DMmobile87

    Thank you, Jesse!! I have been thinking the same thing for quite a long while now. I'm a cancer researcher, but not studying breast cancer. Why is it that nowadays people only equate cancer with breast cancer?? It's not that it doesn't deserve attention, but I don't think it deserves *all* of the attention...

    June 2, 2010 at 19:01 | Report abuse | Reply
  13. Jersey Dude

    36 secs.? Really? Not even a full minute? That has to be really disappointing. Well, I don't think this product is knew. But what a man (and women) can work on (for free) is the Kegel Method. If you get comfortable with this, you will eventually be able to control your body better, and won't need any mecidine.

    Just a thought.

    June 2, 2010 at 21:10 | Report abuse | Reply
  14. Timmy

    LOL. How hilarious 36 seconds. I thought premature ejaculation meant like 2 or 3 minutes but cmon 36 seconds. Seriously they have numbing gels for this stuff. Im sure the ladies will love when these studs last a full 3 and half minutes. lol

    June 2, 2010 at 21:12 | Report abuse | Reply
  15. Andrea M

    3.3 minutes. Sorry boys, but that still qualifies as premature in my book. Granted it's better than 36 seconds, but you're still gonna be embarrassed if you can only have sex for 3.3 minutes.

    June 2, 2010 at 21:17 | Report abuse | Reply
  16. Colleen

    What are these chemicals doing to the inside of a woman's vagina? Does it affect the G spot by numbing it too? What woman can orgasm by vaginal penetration in 3 minutes? I once dated a guy who had premature ejaculation problems. I went to see a sex therapist with him and the therapist tried to suggest that the reason men orgasm prematurely is because women encourage it to boost their self esteem. What a load of crap. I was one majorly unsatisfied partner when it came to intercourse and absolutely did NOT want premature ejaculation to boost my self esteem. I just wanted an orgasm through intercourse. 3 minutes is a joke.

    June 2, 2010 at 21:22 | Report abuse | Reply
  17. Peter Billyeald

    My boyfriend is going to love that I can last just as long as he does! Finally we can open doors that we only fantasized about. Thanks PSD502! I owe you one!

    June 2, 2010 at 21:23 | Report abuse | Reply
  18. John

    Benzocaine? Just rub Orajel on your junk. The active ingredient in Orajel is 20% Benzocaine.

    June 2, 2010 at 21:35 | Report abuse | Reply
  19. John

    36 seconds to 3.3 minutes? Now that's improvement! Stop n' go method should increase intercourse by at least half an hour.

    June 2, 2010 at 21:36 | Report abuse | Reply
  20. greylola

    My wife would kill me if I brought home this product, some of us have just the opposite problem and last far too long (40 min. to over an hr.). This can lead to to making your partners feel as if they are not as desirable as they truly are. The fear of not being able to climax can become fuel to the problem.
    Couples that have a 3 min. problem need to work on making it NOT the problem and work on starting a second or 3rd round, take your time, relax and try again. The day isn't shot after 36 seconds just because you did.

    June 2, 2010 at 21:42 | Report abuse | Reply
  21. Biff

    Who cares about extra time? When I'm done the party's over. Mission accomplished.

    June 2, 2010 at 22:03 | Report abuse | Reply
  22. nate

    well If youre in bed with a smokin hot woman, 36 seconds is about right; now if you are talking about the average american woman (overweight), no need for the spray at all.

    June 2, 2010 at 22:09 | Report abuse | Reply
  23. TFBuckFutter

    As mentioned, similar products have been around for a long time. Of course, use of them is regularly discouraged by most reputable sex therapists for two reasons.....most people don't want to be desensitized during sex, and more importantly is the fact that the "medication" can rub off on the female, desensitizing her as well, and then what is the point of lasting 30 seconds or 45 minutes?

    Just like with diet pills everyone wants an easy fix and a shortcut when what is usually required is training, patience and dedication.

    June 2, 2010 at 22:12 | Report abuse | Reply
  24. Doug

    Good grief! I WISH I only lasted that long. You can always come back for seconds, but I take forever to get there. PE isn't a problem, it just gets the male orgasm out of the way so he can come back and pleasure his partner more thoroughly.....

    June 2, 2010 at 22:13 | Report abuse | Reply
  25. frank in pensacola

    Call me crazy, but something tells me that men w/premature ejaculation problems masturbated to climax once or twice before attempting intimacy leading to intercourse, they'd get far better results than this. The first one (or two) are "easy".

    June 2, 2010 at 22:22 | Report abuse | Reply
  26. big bubba

    Never liked the term "premature ejaculation." it's a misnomer based on unrealistic expectations of the male in this PC society, started by the femanist movement. Males are built to breed, and the sooner they release the sperm the quicker it gets to the egg and the job is done. Expecting men to "hold out" to please the woman goes against nature, and is unhealthy. oral sex is a much better way to please the female, just ask them.

    June 2, 2010 at 22:24 | Report abuse | Reply
  27. Gary P Salmon

    Every High School boy's nightmare! So is the fate of the minuteman!

    June 2, 2010 at 22:25 | Report abuse | Reply
  28. Patti

    Nice, Jesse. Knocking breast cancer research and funding since you are male. So there's no benefit for you, is that it? It's all up for discussion until god forbid someone you know or love is stricken. Close to 50,000 women in the US alone die from breast cancer annually. Grow up.

    June 2, 2010 at 22:34 | Report abuse | Reply
  29. Bonni

    What? 36 seconds? 3.3? I WISH! I must be unlucky to have the seemingly only abnormal boyfriend that (unless I keep telling him to stop) keeps going for 30-1:20 minutes. I orgasm usually in the first 5 minutes and he just keeps going. If I could orgasm more than once I'd be going 8 or 9 times in the time it takes him to finish. It's a gift I guess... and a curse.

    June 2, 2010 at 22:34 | Report abuse | Reply
  30. Cassanova

    Listen... Cassanova says, if a man climaxes in 30 sec...then he's done guilt free. It is the woman's responsibility then to climax in 29 sec or less.

    June 2, 2010 at 23:04 | Report abuse | Reply
  31. marla

    I agree with you Tracy. Every since I first heard about drugs and other things that have been developed for men, I have asked the same question, "what are they doing for women?" I have always felt that the lack of help for women is to control our sexuality. There would be less straying by men if the had truly content wives who feel free enough to express themselves with their husbands. Every advertisement seems to make it seem that a drug used by men will put a satisfied smile on a womans face. There is more to a womans sexuality than the ability of a man to function. We have been told to ask for what we want or need in a non-sexual setting. Been there done that and it didn't work. The response was: I"m working on it." Our sexualtiy starts in the brain, There may be very few women who care about this latest discovery. Especially if they cannot get any where near the mountain top. If this drug basically numbs the glans penis, then won't it numb certain areas on the woman? Its all down hill as far as I am concerned. I have listened to the Bermans and others and it seems that they make gadgets for women that require an expensive prescription.

    June 2, 2010 at 23:05 | Report abuse | Reply
  32. Dak

    They just need to release one from the chamber 8-12 hours before their big date and they'll be fine....

    June 2, 2010 at 23:06 | Report abuse | Reply
  33. Marjorie

    ahahahahaaaaaaaaaaa. What is a joke to you....36 seconds are less... is devastating to so many people!

    June 2, 2010 at 23:27 | Report abuse | Reply
  34. john

    Hey Tracy, let your fingers do the walking... and tell your husband or bf to go masturbate before you have intercourse, maybe then he will last more than 36 seconds?

    June 2, 2010 at 23:29 | Report abuse | Reply
  35. PuddyTatWhisperer

    Poor dudes....looks like you skipped the 'how to please a woman' day during sex ed. If she isn't sighing and purring before you lay the lumber down, you probably don't know what a tongue is for. I pity da fools, as Mr. T would say.

    June 2, 2010 at 23:32 | Report abuse | Reply
  36. Chuck

    Tracy and Zoe, I think maybe you missed this article from last week: http://pagingdrgupta.blogs.cnn.com/2010/05/24/libido-booster-for-women-to-get-fda-consideration/

    Additionally, please read this one: http://www.nytimes.com/2009/11/29/magazine/29sex-t.html?pagewanted=all

    Very different issues for men vs women!

    June 2, 2010 at 23:34 | Report abuse | Reply
  37. MotleyDogg

    Tracy and Zoe,... if there are women with sexual issues,... I will muster all I can to assist with the problems,... they can talk comfortably, have sex, not have sex, with me, with one another,... hey I am here to help!!!!!

    June 2, 2010 at 23:35 | Report abuse | Reply
  38. Eric

    um. i don't know about anyone else, but that is a sensitive spot to try some "new spray". I'll be waiting a LONG time before I consider this.

    June 2, 2010 at 23:36 | Report abuse | Reply
  39. Lenny

    Practice, Practice, Practice! & Repeat! I don't think they need a spray, they need to have more sex. Kinda like use it or lose it type of deal. If you drain the well and keep it drained, it takes longer...

    June 2, 2010 at 23:43 | Report abuse | Reply
  40. cabomambo

    If one tenth of the money spent on fixing men's heads (the little one that rules the big one), how many life threatening women's health
    studies could be funded?

    This is riduculous.

    June 2, 2010 at 23:44 | Report abuse | Reply
  41. Anne

    I'm glad to hear there's something out there to help the guys. But those that nobly claim this is also for the woman's benefit have another think coming.

    Many women do not have vaginal orgasms - ever. It's the clitoral stimulation that leads to orgasms. So pleasure your woman first with oral sex (this may take a while), spray on your PSD502, then enjoy the ride. Your partner will be happy, you will be happy, and she won't care how long the ride took.

    June 2, 2010 at 23:48 | Report abuse | Reply
  42. Cherish

    There are so many non chemical ways to achieve this. Tantra educators can easily teach one to last as long as they want.

    June 2, 2010 at 23:53 | Report abuse | Reply
  43. Honey

    Tracy, this is an article about premature ejaculation for MEN. You sound like one bitter lady. My husband suffers from this and so I suffer as well. This is a drug to help couples. Extended ejaculation for men = more chances of climaxing for women. Get the equation?

    June 2, 2010 at 23:58 | Report abuse | Reply
  44. Mai

    Well thank god there is so little real illness and disability in the world that we can devote the finest medical and pharmaceutical apparatus in history to the hideous tragedy of guys coming too soon.

    June 3, 2010 at 00:03 | Report abuse | Reply
  45. David

    Tracy, lube it up and you can go indefinitely. These men, an avg of 36 seconds. Sorry if I don't feel any sympathy for you.

    June 3, 2010 at 00:05 | Report abuse | Reply
  46. barry

    it always amazes me when so many people are quick to jump to unfounded conclutions. no where in this article did i read that no such studies of any kind are taking place on behalf of woman. this articles point was simply to bring to every ones attention of the study and some of the results. never to suggest that there arent simular ones for woman.. people. read it and move on.

    June 3, 2010 at 00:05 | Report abuse | Reply
  47. SJ

    I've had good results using (don't laugh) Ora-gel... honest!

    June 3, 2010 at 00:06 | Report abuse | Reply
  48. Jim Bob

    Oh for pete's sake, this has been available otc for many years.

    June 3, 2010 at 00:07 | Report abuse | Reply
  49. Louie

    Premature Ejaculation starts in the brain.... If "all" you are thinking of or worried about is "your" orgasam, Of course!!!

    36 seconds is meaningless if your woman will orgasam in 20!

    Stop!, Slow down!, Relax!, Take your time!, Concentrate on pleasing your lady, pay attention to what makes her go wild. Hold off on penetration until "SHE IS READY" Stop thinking about how long you are going to last and start thinking about how hard and loud she will be screaming and clawing your back.

    It's called "Foreplay" It's about giving not taking! Sure it takes practice. . .......It works this way......The more you "give", The more you receive!

    June 3, 2010 at 00:15 | Report abuse | Reply
  50. stacy

    wow..... you straight people sure have a lot of sexual dysfunction

    June 3, 2010 at 00:45 | Report abuse | Reply
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Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.